Navigation Links
Personalizing medicine

AURORA, Colo. (Jan.25, 2011) A federal grant totaling $2.2 million shows how the University of Colorado School of Medicine and Anschutz Medical Campus are using technology to advance the cutting-edge field of personalized medicine -- tailoring treatments to the individual based on their genetic make-up.

The grant also highlights the commitment of the school's Colorado Clinical & Translational Sciences Institute (CCTSI) to bring scientific discoveries to the bedside and to train the next generation of researchers.

The grant will pay for a new PET-CT scanner devoted to research that can precisely detect cancer, brain disorders and other illnesses, and guide treatment.

It also will buy a Next Generation Deep DNA Sequencer. This machine will dramatically cut the cost, time and staffing needed to examine a person's genome.

The grants were made to the CCTSI, which is dedicated to translating research discoveries into improved diagnostics, treatments and preventative and lifestyle interventions. The National Institutes of Health awarded the money.

The more doctors know about a person's genetic make-up, the better the treatment can be. This is already happening with some diseases. For example, dosing for the drug coumarin following a heart attack can now be guided by knowledge of the patient's personal DNA code.

The PET-CT scanner will let researchers peer deep into the human body. It creates a high-resolution, three-dimensional image of the body that is fused with images of radiotracers (a small amount of radioactive material injected into the body). PET-CT provides images of disease, measures the delivery of a drug to diseased tissues and measures effectiveness of the molecular treatment without harming the patient.

"Individualized therapies will reduce patient suffering and extend productive life by selecting the most effective therapeutic weapon for the specific individual," says Gerald D. Dodd, III, MD, chair of the Department of Radiology. "Our children and grand-children will lead better lives due to the studies conducted today."

The Deep DNA Sequencer has revolutionized medical research, and will transform patient diagnosis and treatment. In 2003, thousands of scientists working around the world on the Human Genome Project unveiled the human instruction code the DNA sequence of the human genome. With that knowledge came the promise of tailoring treatment based on a person's unique instruction code. But the cost of first cracking that code was enormous several billion dollars. To make information about a person's genome practical for medicine the process had to become quicker and cheaper.

The device coming to Colorado will provide the sequence of a human genome for $10,000 (a 300,000-fold reduction in cost from that first genome sequence), in about a week (about a 500-fold reduction in time) through the effort of as few as three people. And the cost is expected to come down rapidly while efficiency goes up.

"This instrument brings personalized medicine to the threshold of our clinics," says Mark Johnston, PhD, chair of the Department of Biochemistry and Molecular Genetics. "It is likely that, because of DNA sequencers such as the one we're bringing to Colorado, reading a patient's personal DNA code will be a routine part of the clinical workup within the next five years."

The medical school implemented the first generation of this technology in February 2009, and has provided DNA sequence data to more than 30 investigators at the University of Colorado on the Anschutz Medical Campus and the Boulder Campus.

"In the big picture, this grant furthers our ability to accelerate the pace with which we can bring new discoveries to improve the health and lives of people in Colorado," said Ronald J. Sokol, MD, director and principal investigator of the CCTSI."As an organization focused on putting science to work for patients, we are not only a medical school resource but also a Colorado resource."


Contact: Dan Meyers
University of Colorado Denver

Related biology news :

1. 40-year-old test procedure finds modern niche in developing new medicines
2. Molecular medicine could avert predicted catastrophic vision loss in the aged
3. Penn Medicine researcher receives $6 million grant for cardiovascular disease study
4. Boston University School of Medicine professor receives AACCs Van Slyke Award
5. Medicine: Alzheimers and heart attacks share the same genes
6. Advances in Optics for Biotechnology, Medicine and Surgery XII
7. Reportlinker Adds Personalized Medicine Market - Advances in Human Genomics and Proteomics to Challenge Traditional Therapeutics
8. NIH awards $6.4 million to Case Western Reserve School of Medicine researchers
9. Regenerative medicine workshops to debut at TERMIS North America Annual Conference
10. OGI invests in personalized medicine for age-related macular degeneration
11. NIH renews Nanomedicine Center focused on treating single-gene disorders for $16.1 million
Post Your Comments:
(Date:11/12/2015)... , Nov. 12, 2015  A golden retriever ... Duchenne muscular dystrophy (DMD) has provided a new lead ... Children,s Hospital, the Broad Institute of MIT and Harvard ... Brazil . Cell, pinpoints ... dogs "escape" the disease,s effects. The Boston Children,s lab ...
(Date:11/12/2015)... LONDON , Nov. 11, 2015   ... and reliable analytical tools has been paving the ... and qualitative determination of discrete analytes in clinical, ... sensors are being predominantly used in medical applications, ... and environmental sectors due to continuous emphasis on ...
(Date:11/10/2015)... LONDON , Nov. 10, 2015 /PRNewswire/ ... segmented on the basis of product, type, ... segments included in this report are consumables, ... this report are safety biomarkers, efficacy biomarkers, ... in this report are diagnostics development, drug ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... HOLLISTON, Mass. , Nov. 25, 2015 ... a biotechnology company developing bioengineered organ implants for life-threatening ... will present at the LD Micro "Main Event" investor ... PT. The presentation will be webcast live and posted ... also be available at the conference for one-on-one meetings ...
(Date:11/25/2015)... ... 25, 2015 , ... A long-standing partnership between the Academy ... been formalized with the signing of a Memorandum of Understanding. , AMA Executive ... Karl Minter and Capt. Albert Glenn Tuesday, November 24, 2015, at AMA Headquarters ...
(Date:11/25/2015)... ... November 25, 2015 , ... Jessica Richman and Zachary Apte, ... their initial angel funding process. Now, they are paying it forward to other ... stage investments in the microbiome space. In this, they join other successful ...
(Date:11/24/2015)... Nov. 24, 2015 Cepheid (NASDAQ: CPHD ... at the following conference, and invited investors to participate ...      Tuesday, December 1, 2015 at 11.00 a.m. ...      Tuesday, December 1, 2015 at 11.00 a.m. ... New York, NY      Tuesday, December ...
Breaking Biology Technology: