Navigation Links
Personalized medicine in warfarin therapy
Date:2/25/2010

Columbus, OH Researchers from the Ohio State University have developed a rapid, multiplexed genotyping method to identify the single nucleotide polymorphisms (SNPs) that affect warfarin dose. The related report by Yang et al, "Rapid Genotyping of SNPs Influencing Warfarin Drug Response by SELDI-TOF Mass Spectrometry," appears in the March 2010 issue of the Journal of Molecular Diagnostics.

Warfarin is an anti-coagulant that is commonly used to prevent blood clots and embolism. However, warfarin dosing is complicated by the fact that it interacts with many commonly used medications and even chemicals in some foods. Certain genetic variations, SNPs, also affect warfarin sensitivity and metabolism.

A group led by Dr. Haifeng M. Wu of the Ohio State University has developed a new rapid method to genotype SNPs that will help clinicians to choose appropriate doses of warfarin for individual patients. Using surface-enhanced laser desorption and ionization time-of-flight mass spectrometry (SELDI-TOF MS), which can determine the elemental composition of a sample, Yang et al could determine the genotype of three warfarin-related SNPs in under five hours with high levels of accuracy.

Yang et al suggest that "on-site application of this method in hospital laboratories will greatly help clinicians to determine appropriate doses of warfarin to treat patients with thromboembolic disorders." In future studies, Dr Wu and colleagues plan to apply the SELDI-TOF platform to genotype other medically important SNPs that influence the efficacy and safety profiles of many drug therapies and ultimately to promote personalized health care at Ohio State University .


'/>"/>

Contact: Angela Colmone, Ph.D.
acolmone@asip.org
301-634-7953
American Journal of Pathology
Source:Eurekalert

Page: 1

Related biology news :

1. New genetic research into nicotine addiction shows promise for personalized treatment
2. Emory, Ohio State launch partnership in predictive and personalized health care
3. New clinical trial results show how personalized medicine will alter treatment of genetic disorders
4. Researchers at UH explore patient preferences for personalized medicine
5. Personalized medicine: Innovative online journal leads the way
6. Nutrigenomics -- developing personalized diets for disease prevention
7. Digital communication technology helps clear path to personalized therapies
8. Nutrigenomics -- developing personalized diets for disease prevention -- part 2 just published in OMICS
9. Personalized treatment for early lung cancer
10. New research seeks to enhance quality and security of wireless telemedicine
11. Penn Veterinary Medicine report new strategy to create genetically-modified animals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... 11, 2017 NXT-ID, Inc. (NASDAQ:   ... announces the appointment of independent Directors Mr. Robin D. ... Board of Directors, furthering the company,s corporate governance and expertise. ... Gino Pereira , ... forward to their guidance and benefiting from their considerable expertise ...
(Date:4/4/2017)... --  EyeLock LLC , a leader of iris-based identity ... and Trademark Office (USPTO) has issued U.S. Patent No. ... iris image with a face image acquired in sequence ... th issued patent. "The issuance ... multi-modal biometric capabilities that have recently come to market ...
(Date:3/29/2017)... -- higi, the health IT company that operates the largest ... , today announced a Series B investment from BlueCross ... new investment and acquisition accelerates higi,s strategy to create ... health activities through the collection and workflow integration of ... and secures data today on behalf of over 36 ...
Breaking Biology News(10 mins):
(Date:7/27/2017)... ... July 27, 2017 , ... A luxury car manufacturer ... popular corporate team building events this summer. , Each team gathered ... competition to whet their palettes. Three teams were then formed, and each ...
(Date:7/27/2017)... Md. and RESEARCH TRIANGLE PARK, N.C., July 27, 2017 ... UTHR ) today announced its financial results for ... "Our second quarter total ... net revenue level ever," said Martine Rothblatt, Ph.D., ... continue to believe that Orenitram is well-positioned given ...
(Date:7/26/2017)... ... July 26, 2017 , ... CardioWise, Inc. ... to SQuEEZ heart function analysis software, and an associated pending patent from Johns ... April 10, 2014 and uses high resolution cardiac CT to analyze cardiac wall ...
(Date:7/26/2017)... ... July 26, 2017 , ... Franz Inc ., an ... technology for Knowledge Graphs, today announced Gruff v7.0 , the industry’s leading ... users and graph experts the ability to visually build queries and explore connections ...
Breaking Biology Technology: