Navigation Links
Personalized medicine in warfarin therapy
Date:2/25/2010

Columbus, OH Researchers from the Ohio State University have developed a rapid, multiplexed genotyping method to identify the single nucleotide polymorphisms (SNPs) that affect warfarin dose. The related report by Yang et al, "Rapid Genotyping of SNPs Influencing Warfarin Drug Response by SELDI-TOF Mass Spectrometry," appears in the March 2010 issue of the Journal of Molecular Diagnostics.

Warfarin is an anti-coagulant that is commonly used to prevent blood clots and embolism. However, warfarin dosing is complicated by the fact that it interacts with many commonly used medications and even chemicals in some foods. Certain genetic variations, SNPs, also affect warfarin sensitivity and metabolism.

A group led by Dr. Haifeng M. Wu of the Ohio State University has developed a new rapid method to genotype SNPs that will help clinicians to choose appropriate doses of warfarin for individual patients. Using surface-enhanced laser desorption and ionization time-of-flight mass spectrometry (SELDI-TOF MS), which can determine the elemental composition of a sample, Yang et al could determine the genotype of three warfarin-related SNPs in under five hours with high levels of accuracy.

Yang et al suggest that "on-site application of this method in hospital laboratories will greatly help clinicians to determine appropriate doses of warfarin to treat patients with thromboembolic disorders." In future studies, Dr Wu and colleagues plan to apply the SELDI-TOF platform to genotype other medically important SNPs that influence the efficacy and safety profiles of many drug therapies and ultimately to promote personalized health care at Ohio State University .


'/>"/>

Contact: Angela Colmone, Ph.D.
acolmone@asip.org
301-634-7953
American Journal of Pathology
Source:Eurekalert

Page: 1

Related biology news :

1. New genetic research into nicotine addiction shows promise for personalized treatment
2. Emory, Ohio State launch partnership in predictive and personalized health care
3. New clinical trial results show how personalized medicine will alter treatment of genetic disorders
4. Researchers at UH explore patient preferences for personalized medicine
5. Personalized medicine: Innovative online journal leads the way
6. Nutrigenomics -- developing personalized diets for disease prevention
7. Digital communication technology helps clear path to personalized therapies
8. Nutrigenomics -- developing personalized diets for disease prevention -- part 2 just published in OMICS
9. Personalized treatment for early lung cancer
10. New research seeks to enhance quality and security of wireless telemedicine
11. Penn Veterinary Medicine report new strategy to create genetically-modified animals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... Davis Center for Neuroscience and Department of Psychology ... Faculty Fellowship from the U.S. Department of Defense. ... work on learning and memory in Ranganath,s Dynamic ... project aims to connect neural oscillations, which are ... and hippocampus, brain regions that are known to ...
(Date:8/1/2014)... a key component of phloem, the conductive tissue through ... signalling molecules. Elongated cylindrical cells are capped at one ... form sieve tubes which in turn form a network ... are very special cells which play an important role ... been known about their differentiation," says Professor Yk Helariutta ...
(Date:8/1/2014)... -- LiveScan Service Provider Binary Biometrics is pleased to welcome Kevin ... will improve its mobile service capabilities and add more daily appointments, which will ... service several new cities such as, but not limited to, Daytona ... Deltona , Edgewater , Holly ... Beach , Oak Hill , Orange City ...
Breaking Biology News(10 mins):Developmental regulation of important plant phloem components discovered 2Binary Biometrics, Founded by James Timothy White, Expands Services to 13+ Locations With the Addition of Owner/Operator Kevin Morris 2Binary Biometrics, Founded by James Timothy White, Expands Services to 13+ Locations With the Addition of Owner/Operator Kevin Morris 3
... available in French . Researchers at ... of Canada, the University of Toronto and the SETI ... highly unique spring located on Axel Heiberg Island in ... explains that the Lost Hammer spring supports microbial life, ...
... 3, 2010 A cancer conference dedicated to increased ... bridge Western and Native American approaches to disease and ... Navajos are learning about cancer, adopting measures to help ... opening up to new therapies. The 3rd annual ...
... This release is available in French . , ... Social Sciences, two teams of researchers led by Professor Barbara ... Goldsmiths, University of London, U.K., have brought research in intelligent ... have developed a highly sophisticated concept of interactive clothing whereby ...
Cached Biology News:Could life survive on Mars? Yes, expert says 23rd annual Ft. Defiance Cancer Awareness Conference set for June 5 23rd annual Ft. Defiance Cancer Awareness Conference set for June 5 3Innovative research reawakens human memories through intelligent textiles 2
(Date:8/1/2014)... (PRWEB) August 01, 2014 RURO, ... Solutions provider, today officially announces the opening of ... Boji Science Park, Baoshan District in Shanghai, PRC, ... is under the management of Mr. Shen Gang, ... In the past three years, RURO’s has installed ...
(Date:8/1/2014)... 1, 2014 The  PROPEL Center  of the  ... success rate of early-stage life sciences companies in ... awarded 15 grants to help Illinois ... Conference   in Chicago .   ... North America , bringing more than ...
(Date:8/1/2014)... 2014 BCC Research ( http://www.bccresearch.com ) ... TECHNOLOGIES AND GLOBAL MARKETS , that the global market ... grow to nearly $38.8 billion by 2018, with a ... aptamer delivery category, the fastest moving segment of the ... The field of RNAi therapeutics has shown tremendous growth ...
(Date:7/31/2014)... 2014 Food and natural product ... for food alternatives that offer variety, as well ... ingredient market has numerous players operating in the ... Force Technology (VFT). VFT is a science-driven ... patterns, all tested to produce stable, effective and ...
Breaking Biology Technology:RURO Opens Office in Shanghai, China 2iBIO Institute's PROPEL Center Awards Grants for AdvaMed 2014 to Early-Stage Life Sciences Companies 2iBIO Institute's PROPEL Center Awards Grants for AdvaMed 2014 to Early-Stage Life Sciences Companies 3iBIO Institute's PROPEL Center Awards Grants for AdvaMed 2014 to Early-Stage Life Sciences Companies 4Global Market for RNAi Drug Delivery Technologies to Reach $38.8 Billion in 2018; Aptamer Delivery Segment Surging at 58.2% CAGR 2Global Market for RNAi Drug Delivery Technologies to Reach $38.8 Billion in 2018; Aptamer Delivery Segment Surging at 58.2% CAGR 3Functional Ingredient Manufacturer – Vital Force Technology Infuses Raw Materials & Ingredients with Subtle Energy Formula 2
... April 22 /Xinhua-PRNewswire/ -- Fufeng Group Limited,("Fufeng" or ... "the Group"; HKEx: 546), a leading vertically integrated,manufacturer ... results for the year ended 31 December 2007., ... sales volume of major,products, the Group,s turnover increased ...
... NATICK, Mass., April 21 Boston Scientific,Corporation (NYSE: BSX ... 31, 2008, as well as guidance for net sales and,earnings ... First quarter highlights:, -- Achieved net sales of ... earnings through ongoing, stringent expense management -- Maintained leading ...
... in Response to ... Consumer Demand for Water Safety, MONROVIA, Calif., ... this week, addressing consumer concerns,regarding private well water. Available now ... contaminants with easy-to-use,at-home results, most of which can be completed ...
Cached Biology Technology:Fufeng Announces 2007 Annual Results 2Fufeng Announces 2007 Annual Results 3Boston Scientific Announces Results for First Quarter Ended March 31, 2008 2Boston Scientific Announces Results for First Quarter Ended March 31, 2008 3Boston Scientific Announces Results for First Quarter Ended March 31, 2008 4Boston Scientific Announces Results for First Quarter Ended March 31, 2008 5Boston Scientific Announces Results for First Quarter Ended March 31, 2008 6Boston Scientific Announces Results for First Quarter Ended March 31, 2008 7Boston Scientific Announces Results for First Quarter Ended March 31, 2008 8Boston Scientific Announces Results for First Quarter Ended March 31, 2008 9Boston Scientific Announces Results for First Quarter Ended March 31, 2008 10Boston Scientific Announces Results for First Quarter Ended March 31, 2008 11Boston Scientific Announces Results for First Quarter Ended March 31, 2008 12Boston Scientific Announces Results for First Quarter Ended March 31, 2008 13Boston Scientific Announces Results for First Quarter Ended March 31, 2008 14Boston Scientific Announces Results for First Quarter Ended March 31, 2008 15Boston Scientific Announces Results for First Quarter Ended March 31, 2008 16Boston Scientific Announces Results for First Quarter Ended March 31, 2008 17Boston Scientific Announces Results for First Quarter Ended March 31, 2008 18Silver Lake Research Unveils Watersafe(R) Well Water Test Kit 2
... The Vibratome Company has joined forces ... introduce the Vibratome 800 Tissue Chopper. This ... prepare sections of tissue for metabolic experiments ... and irregular specimens available at biopsy or ...
... a new product number, created to ... showing no availability yet, please order ... or contact customer service for assistance. ... easy grip) Mfr Desig: ...
... is a fluorescence scanner with 1 or ... Packing, Protein, CGH, ) spotted on standard ... of InnoScan700 scanners include three different models:, ... a simultaneous dual fluorescence scanner (635nm and ...
... is a new product number, ... product number. If showing no ... the old Sigma-Aldrich number (R4026) ... assistance. Material: cap polystyrene ...
Biology Products: