Navigation Links
Personalized medicine in warfarin therapy
Date:2/25/2010

Columbus, OH Researchers from the Ohio State University have developed a rapid, multiplexed genotyping method to identify the single nucleotide polymorphisms (SNPs) that affect warfarin dose. The related report by Yang et al, "Rapid Genotyping of SNPs Influencing Warfarin Drug Response by SELDI-TOF Mass Spectrometry," appears in the March 2010 issue of the Journal of Molecular Diagnostics.

Warfarin is an anti-coagulant that is commonly used to prevent blood clots and embolism. However, warfarin dosing is complicated by the fact that it interacts with many commonly used medications and even chemicals in some foods. Certain genetic variations, SNPs, also affect warfarin sensitivity and metabolism.

A group led by Dr. Haifeng M. Wu of the Ohio State University has developed a new rapid method to genotype SNPs that will help clinicians to choose appropriate doses of warfarin for individual patients. Using surface-enhanced laser desorption and ionization time-of-flight mass spectrometry (SELDI-TOF MS), which can determine the elemental composition of a sample, Yang et al could determine the genotype of three warfarin-related SNPs in under five hours with high levels of accuracy.

Yang et al suggest that "on-site application of this method in hospital laboratories will greatly help clinicians to determine appropriate doses of warfarin to treat patients with thromboembolic disorders." In future studies, Dr Wu and colleagues plan to apply the SELDI-TOF platform to genotype other medically important SNPs that influence the efficacy and safety profiles of many drug therapies and ultimately to promote personalized health care at Ohio State University .


'/>"/>

Contact: Angela Colmone, Ph.D.
acolmone@asip.org
301-634-7953
American Journal of Pathology
Source:Eurekalert

Page: 1

Related biology news :

1. New genetic research into nicotine addiction shows promise for personalized treatment
2. Emory, Ohio State launch partnership in predictive and personalized health care
3. New clinical trial results show how personalized medicine will alter treatment of genetic disorders
4. Researchers at UH explore patient preferences for personalized medicine
5. Personalized medicine: Innovative online journal leads the way
6. Nutrigenomics -- developing personalized diets for disease prevention
7. Digital communication technology helps clear path to personalized therapies
8. Nutrigenomics -- developing personalized diets for disease prevention -- part 2 just published in OMICS
9. Personalized treatment for early lung cancer
10. New research seeks to enhance quality and security of wireless telemedicine
11. Penn Veterinary Medicine report new strategy to create genetically-modified animals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... based upon a proxy for impact have been identified ... approach to scientific research. , The researchers from the ... top 100 pathogens affecting humans and the top 100 ... will help governments across the continent plan for risks ... a result of climate change, and for biosecurity. , ...
(Date:8/27/2014)... German . , ... disease affecting the peripheral nervous system. Researchers from the ... Experimental Medicine and University Medical Centre Gttingen have discovered ... rats with the disease. These cells enwrap the nerve ... facilitates the rapid transfer of electrical impulses. If Schwann ...
(Date:8/27/2014)... (June, 2014) Outstanding basic research, a growing ... dedication to patient care have earned the Herbert ... Medical Center (CUMC) and NewYork-Presbyterian Hospital an $18 ... National Cancer Institute (NCI). The grant renews the ... Comprehensive Cancer Centers in New York City and ...
Breaking Biology News(10 mins):Big data approach identifies Europe's most dangerous human and domestic animal pathogens 2Potential therapy for incurable Charcot-Marie-Tooth disease 2Herbert Irving Comprehensive Cancer Center awarded $18 million grant 2Herbert Irving Comprehensive Cancer Center awarded $18 million grant 3Herbert Irving Comprehensive Cancer Center awarded $18 million grant 4
... Children,s Research Hospital have gained new insights into regulation ... As the cell,s molecular overachievers, calpains function ... in tissues, the death of damaged cells, insulin secretion, ... this broad set of responsibilities is that defective or ...
... latest American Chemical Society (ACS) News Service Weekly PressPac with ... Engineering News .,Please credit the individual journal or the American ... CONTENT IS FOR IMMEDIATE RELEASE EXCEPT ARTICLE #5, which is ... ARTICLE #1 FOR IMMEDIATE RELEASE Microcapsules ...
... on the hunt for a better way to clean up ... them watch molecules break down on the surface of a ... "We can see the vibrations of the bonds between the ... the way these vibrations change frequency and intensity with time, ...
Cached Biology News:New insight into the controls on a go-to enzyme 2New insight into the controls on a go-to enzyme 3American Chemical Society's Weekly PressPac -- Nov. 19, 2008 2American Chemical Society's Weekly PressPac -- Nov. 19, 2008 3American Chemical Society's Weekly PressPac -- Nov. 19, 2008 4American Chemical Society's Weekly PressPac -- Nov. 19, 2008 5American Chemical Society's Weekly PressPac -- Nov. 19, 2008 6American Chemical Society's Weekly PressPac -- Nov. 19, 2008 7American Chemical Society's Weekly PressPac -- Nov. 19, 2008 8Researchers shed new light on catalyzed reactions 2Researchers shed new light on catalyzed reactions 3
(Date:8/27/2014)... Varian Medical Systems today broke ground ... Lake City manufacturing facility and allow for the consolidation ... create 1,000 new full time jobs in the state ... home to hardworking people with immense engineering and technical ... success in the manufacturing of our state-of-the-art X-ray technology,” ...
(Date:8/27/2014)... YORK , Aug. 27, 2014 /PRNewswire/ ... research report is available in its catalogue: ... 2014-2018 http://www.reportlinker.com/p02316661/Global-Biodegradable-Packaging-Materials-Market-2014-2018.html ... materials are materials that are readily decomposed ... differs from conventional non-degradable packaging in terms ...
(Date:8/27/2014)... , Aug. 27, 2014 Reportlinker.com announces ... in its catalogue: Global Chelating Agents ... About Chelating Agent A chelating agent ... bonds with metal ions, thereby forming a metal-ion ... metal-ions have on chemical processes, formulations, and the ...
(Date:8/27/2014)... “We are honored to be named ... Thangaraj, CEO of Radiant Sage. “We are offering truly ... imaging corelab market to a different level. We ... to efficiently and effectively manage the massive amounts of ... analyzed and read by trained physicians. Being recognized by ...
Breaking Biology Technology:Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 2Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 3Global Biodegradable Packaging Materials Market 2014-2018 2Global Biodegradable Packaging Materials Market 2014-2018 3Global Biodegradable Packaging Materials Market 2014-2018 4Global Biodegradable Packaging Materials Market 2014-2018 5Global Biodegradable Packaging Materials Market 2014-2018 6Global Biodegradable Packaging Materials Market 2014-2018 7Global Chelating Agents Market 2014-2018 2Global Chelating Agents Market 2014-2018 3Global Chelating Agents Market 2014-2018 4Radiant Sage Named to CIOReview List of 100 Most Promising Technology Companies 2
... great thing about the tech arena: even when the economy ... them turn into start-up ventures (whether self-funded, friends-and-family backed or ... they tend to create jobs. They create lots of jobs. ... companies. , ,The trend shows no sign of slowing. , ...
... into two major groups: open minds in closed societies and ... of products must address the issues of sexual connotation with ... UK went soft and packed up their most cherished and ... all over the world are happy as they seriously objected ...
... nanotechnology exhibit to open Thursday , Madison, Wis. ... an exhibit on advances in nanotechnology, run by the university ... 4:30 p.m. on December 16 during a campus open house, ... in science fiction as the manufacture of tiny robots, has ...
Cached Biology Technology:How to duck the 3 most common entrepreneurial hiring traps 2How to duck the 3 most common entrepreneurial hiring traps 3How to duck the 3 most common entrepreneurial hiring traps 4We are American No sex, please 2We are American No sex, please 3We are American No sex, please 4Tech Digest: Nanotechnology, GE Healthcare, NovaMed, PhysioGenix 2
Mouse monoclonal [ICRF 44] to Integrin alpha M...
CKB Antibody (N-term) Antigen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected within aa 1~100 of human CKB. Molecular Weight: 42644 Da...
384 Cluster Tube Racks...
Leptin Receptor Polyclonal Ab 100 ug purified rabbit anti-mouse Leptin Receptor. Tested in Western blotting....
Biology Products: