Navigation Links
Persistent immunity: Wistar researchers find signals that preserve anti-viral antibodies
Date:9/1/2011

antibodies that bind to portions of the infectious agent. Once bound, the antibodies provide a target for the immune system, allowing immune cells to attack it or any infected cells in order to clear away disease. Antibodies are highly variable proteins that are produced in huge quantities by a subset of white blood cells, called B cells, that have transformed into antibody factories, termed antibody secreting cells (ASCs). Our immune system produces a broad array of antibodies, but during an infection with a virus, for example, the immune system allows the predominant production of antibodies that are directed against the virus. The cells making these particular antibodies are then selected for preservation.

According to Erikson and her colleagues, this act of preservation requires signals, provided by proteins called BLyS and APRIL. Mice that have been exposed to influenza require these proteins in order to sustain anti-influenza ASCs in their lungs. The researchers found that neutralizing BLyS and APRIL reduced the numbers of anti-viral ASCs found in the lungs and bone marrow, yet interestingly, did not affect the ASCs found in spleen or in lymph nodes nearby the lungs.

BLyS and APRIL bind to another protein called TACI, a receptor found on the surface of ASCs, which the researchers see as an important translator for marking the ASCs that will become long-lived.

"We know from humans that the absence or mutation of the TACI gene leads to common variable immunodeficiency disease (CVID) and these patients suffer from recurrent respiratory illnesses because of low amounts of certain antibodies in their bronchial secretions," said Amaya I. Wolf, Ph.D., the study's lead author and a postdoctoral fellow in the Erikson laboratory. "Our studies show that mice that lack TACI can mount an initial B cell response to viral infectionand are able to produce antibodies to flu but these mice fail to maintain anti-viral ASCs over a long period of tim
'/>"/>

Contact: Greg Lester
glester@wistar.org
215-898-3943
The Wistar Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Persistent pollutant may promote obesity
2. Penn-Wistar team gains insight into HIV vaccine failure
3. Wistar scientists find key to keeping killer T cells in prime shape for fighting infection, cancer
4. Wistar Institute researcher receives New Innovator award from NIH
5. Exercise boosts health by influencing stem cells to become bone, not fat, McMaster researchers find
6. Researchers report new understanding of role of telomeres in tumor growth
7. Lawson researchers share in $2.2 million grant
8. NIH-funded researchers discover genetic link to mesothelioma
9. UC Davis researchers find disease-causing fat cells in those with metabolic syndrome
10. Researchers uncover source of Haitian cholera outbreak
11. VBI, Convey Computer partner to deliver technology to biomedical, life sciences researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... commerce market, reminds investors and media that  Mr. David ... CARTES SECURE CONNEXIONS AMERICA 2015, held in Washington ... three-day conference is organized into a series of nine session ... Global Fraud: Where is the Trust in Cyberspace? and ...
(Date:4/27/2015)... , Apr. 27, 2015 NXT-ID, Inc. ... biometric authentication company focused on the growing mobile commerce ... shipping to pre-order customers the first week of May, ... the month of May. Gino ... significant milestone for the company as Wocket® enters the ...
(Date:4/21/2015)... , April 21, 2015 ... evolving government policies are boosting access control systems market ... According to a recently published report by TechSci ... 2020 ", the access control systems market in ... USD1.2 billion by 2020.The access control systems market in ...
Breaking Biology News(10 mins):NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 3Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3
... the brain can come under attack in patients with multiple ... an MS-like disease, the brain,s response to a protein produced ... or cerebellum that comes under fire. The studyfrom researchers at ... Washington University in St. Louiswill be published online on October ...
... possible explanation for why people who eat more fruit and ... They have shown that a fragment released from pectin, found ... to inhibit galectin 3 (Gal3), a protein that plays a ... for the anticancer effects of foods are based on population ...
... journal (October 12th) reveals how scientists from the ... a novel nanomechanical approach to investigate the workings of ... used to combat increasingly resistant infections such as MRSA. ... Gabriel Aeppli, developed ultra-sensitive probes capable of providing new ...
Cached Biology News:Pectin power 2Nanotechnology boosts war on superbugs 2
(Date:5/21/2015)... 21, 2015 W. R. Grace ... facility in Worms, Germany has received good manufacturing ... of the International Pharmaceutical Excipient Council (IPEC) Foundation. ... produce its SYLOID® FP brand of pharmaceutical grade ... following the Curtis Bay, Maryland (USA) and Sorocaba, ...
(Date:5/21/2015)... 20, 2015 Research and Markets ... the "2015 Global Survey on Flow Cytometry ... The primary goal of this research is ... and reagents. Key information the survey seeks to ... flow cytometers, predominantly used applications for flow cytometers, ...
(Date:5/20/2015)... Calif. , May 20, 2015 ... today presented preliminary data demonstrating the ability of ... pulmonary fibrosis (IPF) from other interstitial lung diseases ... suggest the classifier,s potential to help thousands of ... resolve ambiguity in IPF diagnosis – a frequent ...
(Date:5/20/2015)... May 20, 2015  Select Medical Corporation ("Select") ... Trade Commission granted early termination of the waiting ... of 1976, as amended, applicable to the acquisition ... a joint venture that Select has created with ... As previously announced, MJ Acquisition Corporation has signed ...
Breaking Biology Technology:Grace European Facility Receives GMP Excipient Certification for SYLOID® FP Silica Gel 2Global Survey on Flow Cytometry Adoption Trends 2015 2Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 2Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 3Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 4Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 5Select Medical Corporation's Proposed Acquisition of Concentra Inc. through Joint Venture with Welsh Carson Receives Antitrust Clearance 2
... composed of gold nanoparticles and viral particles, woven together ... structure a distinctive mix of hard, metallic nanoparticles ... the very stuff of life, DNA marks a ... of materials to create infinitesimal devices. The research, ...
... Corporation (NYSE: WAT ) today announced ... 7.1 Service Release 7 (SR-7), structurally validated to ... 32bit versions, and Waters new Empower™ 3 Chromatography ... NuGenesis SDMS 7.1 release features new functionality for ...
... Misaligned research, medical challenges and harsh economics are thwarting ... in the United States, according to a trio of ... (Jan. 27) issue of the journal Neuron . ... preventive strategies are being tested in patients firmly in ...
Cached Biology Technology:A mix of tiny gold and viral particles -- and the DNA ties that bind them 2Waters Releases NuGenesis SDMS 7.1 Validated to Support Windows 7 and Empower 3 CDS 2Course correction needed for Alzheimer's therapies, experts warn 2Course correction needed for Alzheimer's therapies, experts warn 3