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Peripheral nerve repair with fat precursor cells led to wider nerves and less muscle atrophy
Date:6/16/2009

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"We found that full regeneration of the sciatic nerve occurred in the rats receiving the autograft, the guide, and the guide loaded with APCs. No regeneration was observed in any of the rats in which the defect was left untreated," said Marra.

Their results also showed that transplanted human-derived APCs survived for up to 12 weeks in the injured peripheral nerve and formed a more robust nerve with nerve cells more than double the size of those formed using the conduit alone.

"The versatility of adult precursor cells, such as those from adipose, for the treatment of a number of disorders is promising and this study demonstrates their potential benefit towards nerve repair," said section editor Dr. John Sladek, professor of pediatrics and neuroscience at the University of Colorado School of Medicine.


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Contact: Anita Srikameswaran
412-647-3555
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

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