Navigation Links
Peripheral immune system may regulate vulnerability to depression
Date:12/12/2013

Hollywood, FL (December 12, 2013) A new study shows that immune cells outside the brain may regulate propensity to develop depression. The data were presented today at the American College of Neuropsychopharmacology (ACNP) Annual Meeting.

Depression is a chronic disorder with a devastating impact on the quality of life, health and life expectancy of those who suffer from the disorder. The underlying causes of the disorder remain something of a mystery.

In a study, led by Georgia Hodes at the Icahn School of Medicine at Mount Sinai, the effects of the circulating pro-inflammatory immune chemical called interleukin-6 on depression-like behaviors was investigated in rodents.

The investigators found that rodents with increased propensity to show depression-like behaviors had elevated levels of circulating interleukin-6, suggesting that individual differences in the peripheral immune system contributes to vulnerability to developing depression.

To more directly investigate the role for immune responses in depression-like behaviors, the investigators used irradiation to lesion the immune system of mice. They then carried out bone marrow transplants to replace the immune system with one from mice that showed either high or low levels of interleukin-6 levels in response to stress. It was found that mice that received transplants from high-responding donors had increased expression of depression-like behaviors compared to those who received transplants from low-responding donors.

The findings suggest that circulating immune chemicals that can act in the brain may influence vulnerability to depression. As noted by Dr. Hodes, "These studies represent a new way of thinking about diagnosing and treating depression as an inflammatory illness in the body rather than the brain."

Future studies will be required in humans to determine if a similar role for the peripheral immune system in depression can be established. If so, this may lead to novel treatment approaches for the disorder.


'/>"/>

Contact: Laura Hill
lhill@acnp.org
American College of Neuropsychopharmacology
Source:Eurekalert

Related biology news :

1. Novel technique to produce stem cells from peripheral blood
2. Significant contribution of Greenlands peripheral glaciers to sea-level rise
3. U of Alberta researcher steps closer to understand autoimmune diseases
4. UCI-led study uncovers how Salmonella avoids the bodys immune response
5. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
6. Immune system implicated in prematurity complication
7. Key to immune system disease could lie inside the cheek
8. New immune defense enzyme discovered
9. New genetic mechanism of immune deficiency discovered
10. Carnegie Mellon fluorescent biosensor reveals mechanism critical to immune system amplification
11. Immune-response genes affecting breast tumor eradication
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2016)... March 31, 2016   ... or the "Company") LegacyXChange is excited to ... its soon to be launched online site for trading ... ) will also provide potential shareholders a sense ... technology to an industry that is notorious for fraud. ...
(Date:3/29/2016)... LegacyXChange, Inc. (OTC: LEGX ... Protect are pleased to announce our successful effort to ... of writing instruments, ensuring athletes signatures against counterfeiting and ... athletes on LegacyXChange will be assured of ongoing proof ... Bill Bollander , CEO states, "By inserting ...
(Date:3/22/2016)... March 22, 2016 ... Sensors Market for Consumer Industry by Type (Image, ... Application (Communication & IT, Entertainment, Home Appliances, ... Forecast to 2022", published by MarketsandMarkets, the ... to reach USD 26.76 Billion by 2022, ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... CAMBRIDGE, Mass. , June 23, 2016 /PRNewswire/ ... the development of novel compounds designed to target ... compound, napabucasin, has been granted Orphan Drug Designation ... in the treatment of gastric cancer, including gastroesophageal ... cancer stemness inhibitor designed to inhibit cancer stemness ...
(Date:6/23/2016)... Prostate Cancer Foundation (PCF) is pleased to announce 24 new Young Investigator ... Members of the Class of 2016 were selected from a pool of 128 ... About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... In a ... Hospital in Denmark detail how a patient who developed lymphedema after being treated for ... The results could change the paradigm for dealing with this debilitating, frequent side effect ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... is exhibiting at the Pennsylvania Convention Center and will showcase its product’s latest ... ClinCapture will also be presenting a scientific poster on Disrupting Clinical Trials in ...
Breaking Biology Technology: