Navigation Links
Periodontal stem cell transplantation shows promise
Date:4/11/2011

Tampa, Fla. (April 11, 2011) Periodontal ligament stem cells (PDLSCs) have been found to be the most efficacious of three kinds of clinically tested dental tissue-derived stem cells, reports a study published in the current issue of Cell Transplantation (20:2), freely available on-line at http://www.ingentaconnect.com/content/cog/ct/.

According to researchers in Seoul, South Korea, transplantation of PDLSCs into beagle dogs modeled with advanced periodontal (gum) disease that affected their premolars and molars, which are morphologically similar to the corresponding areas in human dentition, was most effective. PDLSCs showed the best regenerating capacity of the periodontal ligament (which attaches the tooth to the alveolar bone in which the teeth sit), alveolar bone, cementum (material that comprises the surface of a tooth's root), peripheral nerve and blood vessels when compared to similar transplants using dental pulp stem cells (taken from the center of teeth) or periapical follicular stem cells (taken from the developing root).

"Periodontitis, characterized by bone resorption, periodontal pocketing and gingival inflammation, is the most common cause of tooth loss in adults and affects 10 to 15 percent of adults worldwide," said corresponding author Dr. Pill-Hoon Choung of the Seoul National University School of Dentistry. "Our study sought to evaluate the effectiveness of autologous stem cell transplantation (i.e. transplant of a patient's own cells) using three kinds of autologous dental stem cells similar to mensenchymal stem cells."

Past efforts at improving periodontal regeneration included xenogenic (from a different species) bone particle graft using growth factors, but the clinical results were generally unsatisfactory, said the researchers.

In their stem cell transplant study, Dr. Choung's group found PDLSCs to be most efficacious of the three cell types since they offered the best results with respect to the quality and quantity of regenerated tissues.

"PDLSCs made more calcium nodules and showed higher alkaline phosphatase (ALP) activity than did the other two stem cell varieties," added Dr. Choung.

The researchers concluded that further studies should investigate which factors influence the stabilization and differentiation in the diseased periodontal microenvironment and which factors make the three kinds of dental stem cells react differently in vivo.

"This study highlights the diverse sources of stem cells available in the tissues of the body for repair and how the optimal cell type for possible treatments needs to be determined - in this case for the treatment of dental-related disorders such as gum disease" said Dr. Paul Sanberg, coeditor-in-chief of CELL TRANSPLANTATION and executive director of the University of South Florida Center of Excellence for Aging and Brain Repair.


'/>"/>

Contact: David Eve
celltransplantation@gmail.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related biology news :

1. Joshua E. Neimark Memorial Travel Assistance Award winners investigate stem cell transplantation, sustainable growth, women in academia, and conservation science
2. Scientists grow human liver tissue to be used for transplantation
3. Cell Transplantation reports a success in treating end-stage liver disease
4. Cord blood cell transplantation provides improvement for severely brain-injured child
5. Japanese researchers report on liver transplantation studies using animal and iPS cells
6. New cell transplantation journal launched
7. Ovarian transplantation restores fertility to old mice and also lengthens their lives
8. Coral transplantation the simple and cheap solution to reef restoration
9. Cell Transplantation reports consistent and successful islet isolations offer diabetes hope
10. Novel Parkinsons treatment strategy involves cell transplantation
11. Rare genetic disease successfully reversed using stem cell transplantation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... March 29, 2017  higi, the health IT company ... North America , today announced a Series ... acquisition of EveryMove. The new investment and acquisition accelerates ... tools to transform population health activities through the collection ... higi collects and secures data today on ...
(Date:3/24/2017)... Mar 24, 2017 Research and Markets has ... Market Analysis & Trends - Industry Forecast to 2025" report ... ... at a CAGR of around 15.1% over the next decade to ... report analyzes the market estimates and forecasts for all the given ...
(Date:3/22/2017)... Optimove , provider of the ... as 1-800-Flowers and AdoreMe, today announced two new ... Using Optimove,s machine learning algorithms, these features allow ... recommendations to their customers based not just on ... intent drawn from a complex web of data ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... NC (PRWEB) , ... June 21, 2017 , ... ... for attracting and hiring top executive talent in the life sciences industry, today ... and Manufacturing company. The partnership takes full advantage of Beaker’s expertise in ...
(Date:6/22/2017)... Wendelsheim, Germany (PRWEB) , ... June 22, 2017 ... ... , is taking over the allergy specialists DST Diagnostische Systeme & Technologien GmbH, ... We all know someone who suffers from hay fever, urticaria, asthma, atopic eczema ...
(Date:6/22/2017)... (PRWEB) , ... June 22, 2017 , ... ... superior results to clients throughout the biopharma and life sciences industries, continue to ... industry is seeing. Tunnell’s Kip Wolf will be speaking on “The State of ...
(Date:6/22/2017)... ... June 22, 2017 , ... Charm Sciences, Inc. is pleased ... test was determined to be appropriate as a screening test at dairies and farms ... Charm EZ system, and the Charm EZ Lite system. These systems are a combination ...
Breaking Biology Technology: