Navigation Links
Pennsylvania Hospital surgeon receives grant to develop molecular cardiac surgery
Date:11/28/2007

Charles Bridges, MD, ScD, Associate Professor of Surgery at the University of Pennsylvania Medical Center and Chief of Cardiothoracic Surgery, Pennsylvania Hospital, has been awarded a $3 million grant from the National Heart, Lung and Blood Institute for his work in molecular cardiac surgery: a unique approach to gene therapy for heart failure.

The four-year grant will enable Dr. Bridges to expand upon his current research in large-animal molecular cardiac surgery (a term coined by Dr. Bridges). This methodology could provide alternatives both to heart transplantation and to the use of permanent mechanical-assist devices in some humans with end-stage heart failure. Molecular cardiac surgery, if successful, will be more powerful therapeutically and avoid the problems of rejection, infection, increased stroke risk and device failure often associated with these existing technologies.

Genes, which are carried on chromosomes, are the basic units of heredity. They produce proteins that directly or indirectly carry out all life functions. When genes are absent or defective, proteins are unable to carry out their normal functions, resulting in genetic disorders. In gene therapy, a functioning gene replaces an absent or faulty gene, so that the body can make the correct protein and consequently eliminate the root cause of a disease.

Using molecular cardiac surgery, Dr. Bridges group was the first in the world to convincingly demonstrate that marker genes could be efficiently inserted into the majority of heart muscle cells in large animals like dogs and sheep. What makes this approach so unique is that Dr. Bridges group uses a novel, patent-pending cardiac surgical procedure and specially designed hardware as a platform for the most efficient delivery of genes to heart muscle cells ever achieved in large animals. Prior to Dr. Bridges work, research in other laboratories had not proved successful in achieving global, heart-specific gene
'/>"/>

Contact: Lee-Ann Landis
landisl@uphs.upenn.edu
215-829-8043
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
2. Bioengineers at University of Pennsylvania devise nanoscale system to measure cellular forces
3. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
4. Seattle Childrens Hospital leads $23.7 million NIH grant to study gene repair
5. 3 out of 4 hospital patients suffer from malnutrition regardless of their pathology
6. Nationwide Childrens Hospital involved in expanded access program for treatment of PKU
7. Childrens Hospital studying drug with the potential to prevent/delay onset of type 1 diabetes
8. Cardiologists and heart surgeons meet for Controversies and Advances conference
9. Rutgers Genetics receives $7.8 million for autism research
10. Herr receives Heinz Award for Technology, the Economy and Employment
11. UCI receives $5M from Edwards Lifesciences
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... that fish consumption advisories for expecting mothers are ... like persistent organic pollutants (POPs). , The ... University of Toronto Scarborough PhD student Matt Binnington ... levels of environmental contamination, a mother,s compliance with ... body influenced exposure in her children. , Their ...
(Date:4/17/2014)... A Kansas State University engineer has developed ... remotely detects improvised explosive devices. The same technique ... Dunn, the Steven M. and Kay L. Theede ... and nuclear engineering, and his research team have ... underground or in car trunks. The distance detection ...
(Date:4/17/2014)... in Europe, Asia and the United States are spreading ... impacting native honeybee populations at this time, according to ... including Nosema microsporidia and Varroa ... to these invasive pests, which suggests to us that ... and the United States currently are not necessary in ...
Breaking Biology News(10 mins):Fish consumption advisories fail to cover all types of contaminants 2Patented research remotely detects nitrogen-rich explosives 2East African honeybees are safe from invasive pests… for now 2East African honeybees are safe from invasive pests… for now 3
... who are especially reactive to stress are more vulnerable ... than their peers. But a new longitudinal study suggests ... do well when they,re raised in supportive environments. ... Columbia, the University of California, San Francisco, and the ...
... scientists at Rice University have discovered a new technique ... with tiny explosions. The scientists used lasers to make ... on cancer cells, they found they could tune the ... visible but harmless or large bubbles that burst the ...
... conducted at the University of Maryland,s bat lab shows Egyptian ... sonar directly at it. Instead, they alternately point the sound ... by researchers from Maryland and the Weizmann Institute of Science ... to pinpoint the location of a target, but also makes ...
Cached Biology News:High sensitivity to stress isn't always bad for children 2Rice physicists kill cancer with 'nanobubbles' 2'Zen' bats hit their target by not aiming at it 2'Zen' bats hit their target by not aiming at it 3
(Date:1/15/2014)... and SAN JOSE, California , ... biotechnology company developing antibody-drug conjugates for cancer, today announced the ... of Directors. Dr Reynolds has over 20 years, development experience ... Officer at Seattle Genetics. "I am delighted to ...
(Date:1/15/2014)... 15, 2014 More than 5 million ... 1 in 3 seniors will die with Alzheimer’s or ... jaw-dropping figures have shocked many Americans into looking for ... prevent these tragic age-related cognitive disorders. Jonathan Weisman, president ...
(Date:1/15/2014)... January 15, 2014 2013 was a ... Brain State Technologies®. They saw continued independent research led ... who were awarded a $1 million grant from the ... “Brain and Behavior” a peer reviewed journal, Amy Grant ...
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: 6 p.m. ... Road, Warrington, Pa. , Details: The Hepatitis B ... a cure for hepatitis B and improving the quality of ... Ball on Friday, April 11 at Warrington Country Club in ...
Breaking Biology Technology:Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2
... love this provider of really useful, reliable, and not to mention ... fact came to light a few weeks ago when the Internet ... gourmet chefs to prepare meals (free to employees) for its brainy ... will soon be leaving to start a chain of natural foods ...
... all the time. A company hires an independent computer programmer ... uses to run an important part of its business. All ... ,Even when there is a written contract, the specifics of ... not addressed. , ,Years later (perhaps as a result of ...
... Wis. -- Researchers at the USDA Forest Service ... agencies and the pulp and paper industry in an ... of the paper commonly used in business and government ... , ,The federal government annually buys some 500,000 tons ...
Cached Biology Technology:Is Google's cafeteria a competitive weapon? 2Is Google's cafeteria a competitive weapon? 3Is Google's cafeteria a competitive weapon? 4Who owns software developed for your company? 2Who owns software developed for your company? 3Who owns software developed for your company? 4Reducing brightness to make a better paper 2Reducing brightness to make a better paper 3
... Ion Trap Time of Flight Mass Analyzer for superior sensitivity, mass ... 100 - 25,000 m/z, * Precursor ion selection range: 150 - ... accuracy: 5 ppm with internal reference, * Dynamic range: 4 orders ... ...
... Yeast Display Vector is specifically designed to ... surface of Saccharomyces cerevisiae. Displayed proteins can ... with known or putative ligands. pYD1 uses ... of two domains, Aga1 and Aga2, to ...
... pleiotropic cytokine produced by activated T cells, ... the growth of some tumour and normal ... Kaposis sarcoma cell proliferation, cytokine release from ... expression on hepatoma cells. Mouse OSM was ...
Mouse polyclonal antibody to BTAF1 - BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)...
Biology Products: