Navigation Links
Penn vet researchers show lymphoma drug shrinks dog tumors, could lead to human treatment
Date:7/15/2011

PHILADELPHIA There are many kinds of cancers of the immune system, but one, Activated B-Cell Diffuse Large B-Cell Lymphoma, or ABC-DLBCL, is particularly common and pernicious. Researchers at the University of Pennsylvania's School of Veterinary Medicine have shown for the first time that dogs that develop this disease spontaneously share the same aberrant activation of a critical intracellular pathway with humans. They also found that a drug designed to disrupt this pathway helps to kill tumor cells in the dogs' cancerous lymph nodes.

The research was conducted by Nicola Mason, assistant professor of medicine at Penn Veterinary, along with Michael J. May, associate professor of pharmacology; postdoctoral fellow Anita Gaurnier-Hausser; and veterinary clinical pathologist Reema Patel.

Their work was published in the journal Clinical Cancer Research.

B-cells are the part of the immune system that produce antibodies and protect the body against invading microorganisms or allergens. In ABC-DLBCL, the intracellular signaling pathway involved in B-cell activation and proliferation is, as the name of the disease suggests, constantly activated.

"This signaling pathway, called NF-kappaB, is critical in immune function; following an encounter with antigen, lymphocytes need to be activated and proliferate so that there are sufficient numbers to deal with the invading organism," Mason said. "But in humans with ABC-DLBCL, and also in dogs with spontaneous DLBCL, this pathway is constitutively active and drives lymphocytes to proliferate continuously."

Moreover, these malignant B-cells are resistant to apoptosis, or cell death. Their unchecked growth is the basis of the lymph node tumors that are a hallmark of the disease.

For many years, researchers have been investigating ways of interrupting the malfunctioning pathway that forms the tumors and provides resistance to chemotherapy-induced cell death. In order to
'/>"/>

Contact: Evan Lerner
elerner@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Wood products part of winning carbon-emissions equation, researchers say
2. IRCM researchers uncover a new piece of the puzzle in the development of our nervous system
3. TUM researchers discover a new switch in resistance to plant diseases
4. BUSM researchers urge awareness of dietary iodine intake in postpartum Korean-American women
5. Researchers study pesticide pathways into the atmosphere
6. Johns Hopkins researchers identify new genetic risk factor for sudden cardiac death
7. Johns Hopkins researchers awarded $32 million
8. U of T researchers build an antenna for light
9. Researchers closing in on safe treatment for parasitic diseases
10. Unnatural chemical allows Salk researchers to watch protein action in brain cells
11. UTMB-led researchers awarded $7.8 million for Gulf spill study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... by satellite over a 15-year period off the U.S. ... feed in specific locations each year, according to a ... PLOS ONE by Ladd Irvine from Oregon ... to mitigate human threats to the whale population. , ... recover since the establishment of protections in the mid-1960s. ...
(Date:7/23/2014)... tissue samples cultured from cystic fibrosis patients, scientists at ... Lung Institute have shown that a new CF drug ... drug. , The finding, published today in the journal ... CFTR protein becomes unstable and loses its ability to ... drugs. The research offers several insights into how novel ...
(Date:7/23/2014)... , , , , , ... , , , , , ... chronic diseases and extend healthy lifespan. The idea, they argue, would be to target the... , , ... , , , , , ... , , , , , , , , ...
Breaking Biology News(10 mins):Blue whales' dangerous feeding grounds 2UNC researchers find unsuspected characteristics of new CF drugs, offering potential paths to more effective therapies 2UNC researchers find unsuspected characteristics of new CF drugs, offering potential paths to more effective therapies 3UNC researchers find unsuspected characteristics of new CF drugs, offering potential paths to more effective therapies 4Strategy proposed for preventing diseases of aging 2Strategy proposed for preventing diseases of aging 3Strategy proposed for preventing diseases of aging 4Strategy proposed for preventing diseases of aging 5
... in German . The Deutsche Forschungsgemeinschaft ... new Research Units. This decision was taken by the DFG,s ... the research consortia is to offer researchers the opportunity to ... to establish innovative research directions. As with all ...
... Sandia,s decontamination foam, developed more than a decade ago ... during the 2001 anthrax attacks, is now being used ... chemical engineer in Sandia,s Chemical & Biological Systems Dept. ... renders all types of typical chemical and biological agents ...
... Ganges River ,and Irrawaddy dolphins declared by the ... study ,with Bangladesh Forest Department helped pinpoint location ... The Government of Bangladesh recently declared three new ... world,s largest mangrove ecosystem the Sundarbans, according ...
Cached Biology News:DFG to establish 4 new research units 2DFG to establish 4 new research units 3Anthrax-killing foam proves effective in meth lab cleanup 2Anthrax-killing foam proves effective in meth lab cleanup 3Anthrax-killing foam proves effective in meth lab cleanup 4New protected areas for dolphins declared 2New protected areas for dolphins declared 3
(Date:7/23/2014)... SKOKIE, Ill. , July 23, 2014 ... acid (SNA™) constructs as gene regulatory and ... Snyder has joined AuraSense Therapeutics, executive ... July 11. Prior to joining ... President and Chief Financial Officer of Cellular ...
(Date:7/23/2014)... StemGenex® , the leading resource ... aimed at improving the lives of patients dealing with ... Parkinson’s disease. StemGenex believes that a commitment to ... paramount when providing care to patients with degenerative diseases. ... therapy accessible to the millions of individuals currently living ...
(Date:7/23/2014)... 2014 Shire plc (LSE: ... specialty biopharmaceutical company, and ArmaGen, a US privately ... and collaboration agreement for AGT-182, an investigational enzyme ... both the central nervous system (CNS) and somatic ... This collaboration strengthens Shire,s rare disease pipeline of ...
(Date:7/23/2014)... N.J. (PRWEB) July 23, 2014 ... Comprehensive Cancer Center has joined its Strategic Alliance ... Strategic Alliance Partnership program, UNC Lineberger will have ... to raise awareness of its cutting-edge research initiatives, ... from UNC Lineberger will work with OncLive to ...
Breaking Biology Technology:AuraSense Therapeutics Appoints Biotechnology Veteran David S. Snyder as Chief Financial Officer 2StemGenex® Gives Hope to Parkinson’s Patients through New Stem Cell Clinical Study 2StemGenex® Gives Hope to Parkinson’s Patients through New Stem Cell Clinical Study 3Shire Enters Strategic Licensing and Collaboration Agreement With ArmaGen 2Shire Enters Strategic Licensing and Collaboration Agreement With ArmaGen 3Shire Enters Strategic Licensing and Collaboration Agreement With ArmaGen 4Shire Enters Strategic Licensing and Collaboration Agreement With ArmaGen 5OncLive Expands Its Strategic Alliance Partnership Program With the Addition of UNC Lineberger Comprehensive Cancer Center 2OncLive Expands Its Strategic Alliance Partnership Program With the Addition of UNC Lineberger Comprehensive Cancer Center 3
... on just about anything: Post-Its, a text file on my laptop, ... ,Recently, I've started trying out a free online service, Ta-Da ... track of to-do items. It was made by 37 Signals ... is why they can offer it free without any advertising. , ...
... career, Bob Weisenberg read a lot of books on management ... the way through yet another book, he realized he had ... in the software industry, Weisenberg says the way to excel ... limited number of skills, not by reading more books about ...
... you like your job (or maybe you're not wild about it) ... that keeps you glued to your desk. , ,It could also ... weather's warmer or after the Cubs opener or some other milestone. ... more of these 10 signs may tell you that your Midwest ...
Cached Biology Technology:Ta-Da Lists makes it fun to check things off 2Northwoods Software co-owner distills 30 years of business experience 2Northwoods Software co-owner distills 30 years of business experience 3Northwoods Software co-owner distills 30 years of business experience 4Ten signs tell you to look for a new tech job 2Ten signs tell you to look for a new tech job 3Ten signs tell you to look for a new tech job 4
Umbilical cord blood CD4+ T cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood MNCs and T Cells...
Human endothelial progenitor cells, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Dendritic Cells and EPCs...
Human monocyte-derived dendritic cells, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Dendritic Cells and EPCs...
...
Biology Products: