Navigation Links
Penn team mimicking a natural defense against malaria to develop new treatments
Date:12/27/2012

PHILADELPHIA - One of the world's most devastating diseases is malaria, responsible for at least a million deaths annually, despite global efforts to combat it. Researchers from the Perelman School of Medicine at the University of Pennsylvania, working with collaborators from Drexel University, The Children's Hospital of Philadelphia, and Johns Hopkins University, have identified a protein in human blood platelets that points to a powerful new weapon against the disease. Their work was published in this months' issue of Cell Host and Microbe.

Malaria is caused by parasitic microorganisms of the Plasmodium genus, which infect red blood cells. Recent research at other universities showed that blood platelets can bind to infected red blood cells and kill the parasite, but the exact mechanism was unclear. The investigators on the Cell Host and Microbe paper hypothesized that it might involve host defense peptides (HDP) secreted by the platelets.

"We eventually found that a single protein secreted when platelets are activated called human platelet factor 4 [hPF4] actually kills parasites that are inside red cells without harming the red cell itself," explains senior author Doron Greenbaum, PhD, assistant professor of Pharmacology, whose team studies innovative ways to fight malaria. The hPF4 targets a specific organelle of the Plasmodium falciparum parasite called the digestive vacuole, which essentially serves as its "stomach" for the digestion of hemoglobin. The investigators found that hPF4 destroys the vacuole with a deadly speed of minutes or even seconds, killing the parasite without affecting the host cell.

While host defense peptides appear to be attractive therapeutic agents, the expense of manufacturing this protein lessens its potential impact on the treatment of malaria. Greenbaum and colleagues set out to discover whether synthetic molecules mimicking the structure of HDPs could have simi
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. EU FET program funds research on 3D neuronal structures mimicking human brain tissue
2. Hormone-mimicking chemicals cause inter-species mating
3. Energy Deptartment funds UW project to turn wasted natural gas into diesel
4. Hagfish slime as a model for tomorrows natural fabrics
5. Natural fungus may provide effective bed bug control
6. Temporary storage for electrons: Natural method of producing hydrogen
7. Research provides new insights into dogs natural feeding behavior and finds they target a daily dietary intake that is high in fat
8. Study: DNA barcoding can ID natural health products
9. Scientists reveal how natural antibiotic kills tuberculosis bacterium
10. Natural regeneration building urban forests, altering species composition
11. Carnegie Mellon study shows skin-aging radicals age naturally formed particles in the air
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn team mimicking a natural defense against malaria to develop new treatments
(Date:7/11/2014)... University, Sweden, have explored two different ways that ... leading to the formation of oxygen molecules in ... the scientific journal Nature Communications . , ... synthetic catalysts for water oxidation, which are key ... direct storage of solar energy in fuels like ...
(Date:7/11/2014)... under the normal circumstances, astrocytes participate in ... environment, and exhibit therapeutic and repairing effects ... studies have found that nerve cells differentiated ... have reduced viability, which produces influences on ... Kailuan General Hospital, Hebei United University, China ...
(Date:7/10/2014)... and other major cities in New Mexico, nearly every ... wastewater rather than precious potable water supplies. Across the ... all golf courses receive treated effluent. Reusing the effluent ... golf courses and homeowners alike fertilize their lawns during ... nitrate. A New Mexico State University turfgrass expert has ...
Breaking Biology News(10 mins):Molecular snapshots of oxygen formation in photosynthesis 2'Tailored' water -- the latest in lawn care 2
... explain the response of patients with chronic obstructive pulmonary ... reported today (Oct. 25) at the American Society of ... used statistical methods to combine results from four individual ... moderate to severe COPD. Over 6.3 million unique ...
... cells. They,re equally indispensible in both cases. Without our bony ... cytoskeletons, our cells, which come in roughly 200 different shapes ... Using cells from the stem of a seedling as ... St. Louis seeks to understand the molecular mechanisms that organize ...
... is hosting the region,s leading scientists for discussions ... most devastating and intractable diseases of humans, including ... fungal meningitis. The Cell Biology of Eukaryotic ... campus and provides an environment for scientific discussions ...
Cached Biology News:DNA variants may influence COPD patients' response to inhaled bronchodilators 2Samurai sword protein makes strategic cuts in cell skeletons 2Samurai sword protein makes strategic cuts in cell skeletons 3Samurai sword protein makes strategic cuts in cell skeletons 4Samurai sword protein makes strategic cuts in cell skeletons 5
(Date:7/11/2014)... AZ (PRWEB) July 11, 2014 ... device company specializing in the soft tissue reconstruction ... All-Suture Anchor System for surgeries involving the shoulder ... fixation through a novel, inserter-controlled deployment method. The ... to partial deployment, anchor pull-out, or anchor displacement ...
(Date:7/10/2014)... (PRWEB) July 10, 2014 Understanding the ... channel-expressing cell lines, and the gap that currently exists ... that expand its industry-leading portfolio of validated ion channel ... ion channel-expressing cell lines, as ion channels control many ... control this activity creates the potential to treat a ...
(Date:7/10/2014)... CA (PRWEB) July 10, 2014 OMICS ... Bioanalytical techniques during 18-20 August, 2014 at Double Tree ... review the recent developments in Analytical & Bioanalytical research ... globe. , Speaking on this occasion, Dr. Srinubabu Gedela, ... Analytica Acta conference is a remarkable one in bringing ...
(Date:7/10/2014)... 2014 On July 9 Prime ... presented Russia,s first national "Industry" ... Company is developing a unique project called MabNext ... a number of innovative drugs based on monoclonal antibodies ... took place at the International Exhibition "Innoprom 2014" in ...
Breaking Biology Technology:Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 3Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2
... YORK, Sept. 24 Stephen Simes, chief executive,officer ... (http://www.biosantepharma.com ) will be featured in an exclusive ... at 10:30 a.m. EDT. The interview,will be posted ... on September 26. The interview will cover ...
... Kendle (Nasdaq: KNDL ), a,leading, global ... President and Chief Financial Officer Karl,"Buzz" Brenkert, III ... at the Grand Hyatt New York, Park Avenue ... Kendle,s presentation is scheduled for,Wednesday, Sept. 26 at ...
... WILMINGTON, Mass., Sept. 24 OmniSonics Medical,Technologies, Inc., ... vascular disease, today announced the appointment of J. ... Board. Mr. Cole is a founding partner ... focuses exclusively on emerging healthcare technology,companies. He brings ...
Cached Biology Technology:WallSt.net Announces Upcoming Interview with CEO of BioSante Pharmaceuticals 2Kendle to Present at the UBS Global Life Sciences Conference 2OmniSonics Appoints J. Daniel Cole Chairman of the Board 2
...
... Modification Services ,,GenScript offers many ... and antibody fragmentation. Labeling antibodies with ... visualization and quantitation of the target ... preferable to use only the antigen-binding ...
... are designed for ultra-sensitive detection of ... PVDF membranes. Since all necessary reagents ... antibodies), the WesternBreeze Kits save you ... and getting your final results. Solutions ...
Request Info...
Biology Products: