Navigation Links
Penn team links placental marker of prenatal stress to brain mitochondrial dysfunction
Date:6/18/2014

han control mice.

Because of the key role that that the hypothalamus plays in controlling growth and many other critical survival functions, the Penn Vet researchers then screened the mouse genome for genes with differential expression in the hypothalamus, comparing normal mice, mice with reduced OGT and mice born to stressed mothers.

They identified several gene sets related to the structure and function of mitochrondria, the powerhouses of cells that are responsible for producing energy. And indeed, when compared by an enzymatic assay that examines mitochondria biogenesis, both the mice born to stressed mothers and mice born to mothers with reduced OGT had dramatically reduced mitochondrial function in their hypothalamus compared to normal mice. These studies were done in collaboration with Narayan Avadhani's lab at Penn Vet.

Such reduced function could explain why the growth patterns of mice appeared similar until weaning, at which point energy demands go up.

"If you have a really bad furnace you might be okay if temperatures are mild," Bale said. "But, if it's very cold, it can't meet demand. It could be the same for these mice. If you're in a litter close to your siblings and mom, you don't need to produce a lot of heat, but once you wean you have an extra demand for producing heat. They're just not keeping up."

Bale points out that mitochondrial dysfunction in the brain has been reported in both schizophrenia and autism patients.

In future work, Bale hopes to identify a suite of maternal plasma stress biomarkers that could signal an increased risk of neurodevelopmental disease for the baby.

"With that kind of a signature, we'd have a way to detect at-risk pregnancies and think about ways to intervene much earlier than waiting to look at the term placenta," she said.


'/>"/>

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Incisive research links teeth with diet
2. New lab mice cut search for genetic links to disease by more than a decade
3. Geographic information systems demonstrate links between health and location
4. Desert to Rainforest global classroom links future teachers, classrooms in Phoenix and Panama
5. 50 years of bird poop links DDT with changing bird menus
6. New study links air pollution and early death in the UK
7. Fossil egg discovered in Lleida (Spain) links dinosaurs to modern birds
8. Research links extreme summer heat events to global warming
9. 10 new diabetes gene links offer picture of biology underlying disease
10. Researchers study links between conflict and fisheries in East Africa
11. 3 new genetic links to colorectal cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn team links placental marker of prenatal stress to brain mitochondrial dysfunction
(Date:8/1/2014)... is tricky enough. Knowing what causes them at the ... of Iowa researchers have created the most detailed map ... long associated with blinding diseases, such as age-related macular ... in the choroid, which supplies blood and oxygen to ... differences in the abundance of proteins in different areas ...
(Date:8/1/2014)... 2014Biologists at The Scripps Research Institute (TSRI) have identified ... process in brown fat cells. , The study, ... of the Proceedings of the National Academy of ... "brown fat thermogenesis," which is of great interest to ... may also protect against diabetes. , "This finding offers ...
(Date:7/31/2014)... a decade ago, prestin was found to be a key ... protein found in the hair cells of the inner ear ... the cochlea, like an antique phonograph horn, amplify sound waves ... new study published in the advanced online edition of ... shown that prestin has also independently evolved to play a ...
Breaking Biology News(10 mins):A map for eye disease 2Scripps Research Institute scientists find new calorie-burning switch in brown fat 2Scripps Research Institute scientists find new calorie-burning switch in brown fat 3
... 2013: Phthalates are among a group of industrial ... on reproductive health and development, particularly in the,male. ... "endocrine disruptors", and proposed as,one of several possible ... They are,classified in two groups - high molecular ...
... for the production of renewable and clean energy, photoelectrochemical ... PECs are devices able of splitting water molecules into ... solar radiation. "As a matter of fact, we,ve already ... the Laboratory of Photonics and Interfaces (LPI) at EPFL ...
... of Toronto-based researchers may be one step closer to a ... research and therapy. Induced pluripotent stem cells (iPSCs) can ... flexibly develop into many different types of cells. However, producing ... generation are largely unknown. But researchers from the University ...
Cached Biology News:Adverse effects of phthalates on ovarian response to IVF 2Champion nano-rust for producing solar hydrogen 2Toronto team IDs proteins key in stem cell production 2
(Date:8/1/2014)... This is a professional and in-depth study on ... Global and China. The report provides a basic overview ... structure. Global market analysis and Chinese domestic market analysis ... and competitive landscape of the market. A comparison between ... The report also focuses on development policies and plans ...
(Date:8/1/2014)... 1. 2014 As one of the 10 ... Annual Meeting & Clinical Lab Expo is the place ... are introduced to the healthcare world. This year, many ... exhibitors will include the latest diagnostic technology in the ... smartphones and biosensors have enabled the development of "labs-on-a-chip" ...
(Date:8/1/2014)... , Aug. 1, 2014 The  PROPEL Center ... number and success rate of early-stage life sciences companies ... it has awarded 15 grants to help ... The MedTech Conference   in Chicago ... conference in North America , bringing ...
(Date:8/1/2014)... 01, 2014 Once a decision has ... This webinar will discuss how to define your tolerance ... speakers Bob Allen, Senior Director of Facilities Integration at ... at Fluor Industrial Services, and special guest Carrier Li, ... at Amgen, as they provide an examination of the ...
Breaking Biology Technology:Ammonium Bicarbonate Market in Internations & Chinese Regions Research Analysis Now Available at DeepResearchReports.com 2Ammonium Bicarbonate Market in Internations & Chinese Regions Research Analysis Now Available at DeepResearchReports.com 3Lab-on-a-Chip Technology to Be Featured at 2014 AACC Annual Meeting & Clinical Lab Expo 2Lab-on-a-Chip Technology to Be Featured at 2014 AACC Annual Meeting & Clinical Lab Expo 3iBIO Institute's PROPEL Center Awards Grants for AdvaMed 2014 to Early-Stage Life Sciences Companies 2iBIO Institute's PROPEL Center Awards Grants for AdvaMed 2014 to Early-Stage Life Sciences Companies 3iBIO Institute's PROPEL Center Awards Grants for AdvaMed 2014 to Early-Stage Life Sciences Companies 4Defining Low Cost in Your Solution for Future Facilities, New Webinar for Pharma, Biotech, Medical Device and Healthcare Companies, Hosted by Xtalks 2
... , BONITA SPRINGS, Fla., Nov. ... and the technology group The Linde Group ... in order to identify the optimum management of carbon ... and photobioreactor technology. This cooperation will see the companies ...
... , , TUSTIN, Calif., Nov. 18 ... announced that researchers presented positive data on progress in ... confirming that its phosphatidylserine (PS)-targeting antibodies bind to VHF ... a model of lethal VHF infection. The data ...
... ... conference will demonstrate how our military trains for irregular warfare--for combat, and just as ... populations in Orlando, FL on November 30 to December 3. , ... Orlando, FL (Vocus) November 18, 2009 ...
Cached Biology Technology:Algenol Biofuels and The Linde Group Agree To Cooperate in CO2 and O2 Management For Biofuel Production From Algae 2Algenol Biofuels and The Linde Group Agree To Cooperate in CO2 and O2 Management For Biofuel Production From Algae 3Peregrine Pharmaceuticals Presents Promising Antiviral Data at 2009 Chemical and Biological Defense Science & Technology Conference 2Peregrine Pharmaceuticals Presents Promising Antiviral Data at 2009 Chemical and Biological Defense Science & Technology Conference 3Peregrine Pharmaceuticals Presents Promising Antiviral Data at 2009 Chemical and Biological Defense Science & Technology Conference 4Peregrine Pharmaceuticals Presents Promising Antiviral Data at 2009 Chemical and Biological Defense Science & Technology Conference 5Peregrine Pharmaceuticals Presents Promising Antiviral Data at 2009 Chemical and Biological Defense Science & Technology Conference 6Huge Exhibition to Demonstrate Training for Irregular Warfare 2Huge Exhibition to Demonstrate Training for Irregular Warfare 3
... Thermo has established an expertise in ... both for solid support synthesis and synthesis ... controlled by Mass Spectrometry and analytical HPLC ... provide products that meet the highest quality ...
The Wellwash 4 Mk 2 microplate washer combines flexibility, simplicity and ease of use. This reliable microplate washer meets the exacting standards of today's ELISA assay requirements....
... These handy dispensers save space and ... and other garb. They are the ... parts used in labs, processing and ... charges and the particles they attract. ...
... dispensers save space and organize ... and other garb. They are ... for small parts used in ... acrylic. Many other sizes and ...
Biology Products: