Navigation Links
Penn team links placental marker of prenatal stress to brain mitochondrial dysfunction
Date:6/18/2014

baby's developing brain."

To elucidate how reduced levels of OGT might be transmitting signals through the placenta to a fetus, Bale and Howerton bred mice that partially or fully lacked OGT in the placenta. They then compared these transgenic mice to animals that had been subjected to mild stressors during early gestation, such as predator odor, unfamiliar objects or unusual noises, during the first week of their pregnancies.

The researchers performed a genome-wide search for genes that were affected by the altered levels of OGT and were also affected by exposure to early prenatal stress using a specific activational histone mark and found a broad swath of common gene expression patterns.

They chose to focus on one particular differentially regulated gene called Hsd17b3, which encodes an enzyme that converts androstenedione, a steroid hormone, to testosterone. The researchers found this gene to be particularly interesting in part because neurodevelopmental disorders such as autism and schizophrenia have strong gender biases, where they either predominantly affect males or present earlier in males.

Placentas associated with male mice pups born to stressed mothers had reduced levels of the enzyme Hsd17b3, and, as a result, had higher levels of androstenedione and lower levels of testosterone than normal mice.

"This could mean that, with early prenatal stress, males have less masculinization," Bale said. "This is important because autism tends to be thought of as the brain in a hypermasculinized state, and schizophrenia is thought of as a hypomasculinized state. It makes sense that there is something about this process of testosterone synthesis that is being disrupted."

Furthermore, the mice born to mothers with disrupted OGT looked like the offspring of stressed mothers in other ways. Although they were born at a normal weight, their growth slowed at weaning. Their body weight as adults was 10-20 percent lower t
'/>"/>

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Incisive research links teeth with diet
2. New lab mice cut search for genetic links to disease by more than a decade
3. Geographic information systems demonstrate links between health and location
4. Desert to Rainforest global classroom links future teachers, classrooms in Phoenix and Panama
5. 50 years of bird poop links DDT with changing bird menus
6. New study links air pollution and early death in the UK
7. Fossil egg discovered in Lleida (Spain) links dinosaurs to modern birds
8. Research links extreme summer heat events to global warming
9. 10 new diabetes gene links offer picture of biology underlying disease
10. Researchers study links between conflict and fisheries in East Africa
11. 3 new genetic links to colorectal cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn team links placental marker of prenatal stress to brain mitochondrial dysfunction
(Date:9/19/2014)... years has adapted to the arctic cold, and then you ... for you. , This is happening to the small white ... called nonylphenol, comes from the use of certain detergents, pesticides ... disruptor, but when entering the worm it has another dangerous ... in its body from cold damage. , Enchytraeus albidus ...
(Date:9/18/2014)... GSA Bulletin study uses tree rings to document ... Wash in northern New Mexico, USA. By determining burial ... investigators were able to precisely date arroyo sedimentary beds ... data with aerial imagery, LiDAR, longitudinal profiles, and repeat ... Arroyos are deep, oversized channels that have vertical or ...
(Date:9/18/2014)... A novel robotic system that can operate inside the ... as part of a biomedical research partnership program at ... of determining if the robot, in conjunction with real-time ... accurate, less costly, and less discomforting for the patient. ... prostate cancer therapies with greater precision. , Developed by ...
Breaking Biology News(10 mins):Environmental pollutants make worms susceptible to cold 2Environmental pollutants make worms susceptible to cold 3Tree rings and arroyos 2Tree rings and arroyos 3Tree rings and arroyos 4Tree rings and arroyos 5Tree rings and arroyos 6Tree rings and arroyos 7Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 2Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 3Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 4Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 5
... MARC (Minority Access to Research Careers) Program has ... Annual International Conference on Intelligent Systems for Molecular ... on Computational Biology (ECCB), an official conference of ... Vienna, Austria from July 15-19, 2011. These ...
... (CHICAGO) Women with the BRCA1 or BRCA2 gene ... of breast and ovarian cancer, can safely take hormone-replacement ... of their ovaries, according to new research from the ... which will be presented Monday, June 6 during the ...
... Event details: , 4:00 5:00 PM eastern, Monday, June ... The Gulf of Mexico is vital to the United States ... recreational fishery production, shipping, and tourism. Its cultural significance ... inhabitants in the face of disasters has inspired the rest ...
Cached Biology News:Women with BRCA mutations can take hormone-replacement therapy safely after ovary removal 2Women with BRCA mutations can take hormone-replacement therapy safely after ovary removal 3Gulf of Mexico ecosystems 1 year after the Deepwater Horizon 2Gulf of Mexico ecosystems 1 year after the Deepwater Horizon 3
(Date:9/19/2014)... electricity, to move data would consume much less ... concern as chips, transistor counts rise. , Of ... light emitters, modulators, and detectors emitters are ... for optical chips is molybdenum disulfide (MoS2), which ... single, atom-thick layer. Other experimental on-chip light emitters ...
(Date:9/19/2014)... Sept. 19, 2014  Nektar Therapeutics (NASDAQ: ... studies characterizing the analgesic profiles of a series ... receptor agonist molecules. The preclinical research candidates were ... platform. The analgesic properties of kappa ... literature. 1,2 Kappa opioid receptors are expressed ...
(Date:9/19/2014)... 19, 2014 Cereal grain scientists, ... will gather October 5–8, 2014, for the AACC ... Convention Center in Providence, Rhode Island. The comprehensive ... of food scientists, chemists, microbiologists, nutritionists, and those ... production management. To date, 1,000 attendees have registered ...
(Date:9/18/2014)... (PRWEB) September 18, 2014 Bipartisan passage ... a bill designed to stimulate development and commercialization of ... being praised by leaders of SPIE, the international ... Revitalizing American Manufacturing and Innovation (RAMI) Act, now moves ... authors have said they are optimistic that it will ...
Breaking Biology Technology:Toward optical chips 2Toward optical chips 3Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 2Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 3Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 4Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 5Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 2Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 3House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 2House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 3
... , , , ... 8 Peregrine Pharmaceuticals, Inc. (Nasdaq: PPHM ) today ... bavituximab in combination with carboplatin and paclitaxel in advanced breast cancer ... enrolled and patients are currently undergoing treatment and follow-up. The ...
... , , ATLANTA and BRIDGEWATER, N.J. ... pollen, as parents prepare for this year,s back to school they should ... nasal allergies ease into the new school year, the My Xperts(TM) program, ... a team of indoor and outdoor nasal allergy experts to help parents ...
... , NOVATO, Calif., Sept. 8 BioMarin Pharmaceutical Inc. (Nasdaq: ... of BioMarin, will present a company update at the Morgan Stanley Healthcare ... p.m. ET. , , Interested parties may ... section of the BioMarin website, www.BMRN.com . A ...
Cached Biology Technology:Peregrine Pharmaceuticals Reports Advances in Bavituximab Clinical Program 2Peregrine Pharmaceuticals Reports Advances in Bavituximab Clinical Program 3Peregrine Pharmaceuticals Reports Advances in Bavituximab Clinical Program 4Peregrine Pharmaceuticals Reports Advances in Bavituximab Clinical Program 5VIDEO: Nasal Allergy Experts Offer Free Advice for Back to School Sneezin' 2VIDEO: Nasal Allergy Experts Offer Free Advice for Back to School Sneezin' 3VIDEO: Nasal Allergy Experts Offer Free Advice for Back to School Sneezin' 4VIDEO: Nasal Allergy Experts Offer Free Advice for Back to School Sneezin' 5VIDEO: Nasal Allergy Experts Offer Free Advice for Back to School Sneezin' 6BioMarin to Present at the Morgan Stanley Healthcare Conference 2
Anti-Indolamine (Indoleamine) 2,3-dioxygenase Immunogen: Recombinant human IDO. Available Date: 38454...
Anti-Ephrin B1 Host: rabbit polyclonal Species Reactivity: human Applications: WB Storage: 4C...
Human Regulatory T cell Staining Kit #2 (w/ APC Foxp3 PCH101, FITC CD4, PE CD25)...
...
Biology Products: