Navigation Links
Penn team links placental marker of prenatal stress to brain mitochondrial dysfunction
Date:6/18/2014

When a woman experiences a stressful event early in pregnancy, the risk of her child developing autism spectrum disorders or schizophrenia increases. Yet how maternal stress is transmitted to the brain of the developing fetus, leading to these problems in neurodevelopment, is poorly understood.

New findings by University of Pennsylvania School of Veterinary Medicine scientists suggest that an enzyme found in the placenta is likely playing an important role. This enzyme, O-linked-N-acetylglucosamine transferase, or OGT, translates maternal stress into a reprogramming signal for the brain before birth.

"By manipulating this one gene, we were able to recapitulate many aspects of early prenatal stress," said Tracy L. Bale, senior author on the paper and a professor in the Department of Animal Biology at Penn Vet. "OGT seems to be serving a role as the 'canary in the coal mine,' offering a readout of mom's stress to change the baby's developing brain."

Bale also holds an appointment in the Department of Psychiatry in Penn's Perelman School of Medicine. Her co-author is postdoctoral researcher Christopher L. Howerton. The paper was published online in PNAS this week.

OGT is known to play a role in gene expression through chromatin remodeling, a process that makes some genes more or less available to be converted into proteins. In a study published last year in PNAS, Bale's lab found that placentas from male mice pups had lower levels of OGT than those from female pups, and placentas from mothers that had been exposed to stress early in gestation had lower overall levels of OGT than placentas from the mothers' unstressed counterparts.

"People think that the placenta only serves to promote blood flow between a mom and her baby, but that's really not all it's doing," Bale said. "It's a very dynamic endocrine tissue and it's sex-specific, and we've shown that tampering with it can dramatically affect a
'/>"/>

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Incisive research links teeth with diet
2. New lab mice cut search for genetic links to disease by more than a decade
3. Geographic information systems demonstrate links between health and location
4. Desert to Rainforest global classroom links future teachers, classrooms in Phoenix and Panama
5. 50 years of bird poop links DDT with changing bird menus
6. New study links air pollution and early death in the UK
7. Fossil egg discovered in Lleida (Spain) links dinosaurs to modern birds
8. Research links extreme summer heat events to global warming
9. 10 new diabetes gene links offer picture of biology underlying disease
10. Researchers study links between conflict and fisheries in East Africa
11. 3 new genetic links to colorectal cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn team links placental marker of prenatal stress to brain mitochondrial dysfunction
(Date:9/17/2014)... decades of decline, grasses have returned to some once-denuded ... marsh in those places seems healthy again, but a ... the marsh coastal protection remains diminished. , ... hasn,t come back," said ecologist Mark Bertness, professor of ... in the journal Biological Conservation . "The metric ...
(Date:9/17/2014)... a new crime unit designed to fight food fraud ... horse meat being passed off as beef scientists ... adulteration. They describe their approach, which represents a vast ... Agricultural and Food Chemistry . , Hans-Ulrich Humpf and ... economic problem. But they also say that adding, for ...
(Date:9/17/2014)... bacterial infections, including MRSA and MSSA could be ... that mimic the scaly surface of shark skin, ... journal Antimicrobial Resistance and Infection Control . ... prevented the spread of human disease bacteria through ... is an arrangement of ridges formulated to resemble ...
Breaking Biology News(10 mins):Cape Cod saltmarsh recovery looks good, falls short 2Cape Cod saltmarsh recovery looks good, falls short 3Sharks' skin has teeth in the fight against hospital superbugs 2
... Researchers at Indiana University School of Medicine are several steps closer ... cells could be used to let him or her hear the ... able to transform, in the laboratory, stem cells taken from adult ... nerve cells -- neurons -- found in the ear. The results ...
... at New York University and Rockefeller University have ... shown to have key roles in gene regulation, ... mammals. MicroRNAs are a recently discovered large class ... complementary sites in target messenger RNA to regulate ...
... to visualize more of the arteries in the lungs, ... seeing more may have little impact on the patient's ... 198 patients with suspected pulmonary embolism. About half of ... 100 patients had a single-detector CT examination. The radiology ...
Cached Biology News:Researchers Closer To Helping Hearing-Impaired Using Stem Cells 2NYU, Rockefeller researchers find complexity of regulation by microRNA genes 2Newer imaging techniques may lead to over-treatment 2
(Date:9/17/2014)... PARK, N.C. , Sept. 17, 2014  The ... presentation topics that will be featured at the conference, ... Conference Center on December 3 and 4, 2014. Researchers, ... are invited to hear the following: ... UC San Diego Skaggs School of Pharmacy ...
(Date:9/17/2014)... COLUMBIA, Md. (PRWEB) September 17, 2014 ... Nexera-e Comprehensive Two-Dimensional Liquid Chromatograph (2D-LC), which ... most complex sample matrices. The system provides ... of sample analytes, which is beneficial to ... food extracts, and natural products. , Comprehensive ...
(Date:9/17/2014)... San Jose, California (PRWEB) September 17, 2014 ... disintegrated by naturally occurring microorganisms such as bacteria, ... subsequently transformed into water, methane, biomass, inorganic compounds, ... With enhanced processability, expanding customer base and improved ... environmentally beneficial and economically viable alternative to conventional ...
(Date:9/17/2014)... , Sept. 17, 2014 BioClinica®, Inc., ... eClinical Solutions, today announced three of its experts are ... for Clinical Data Management to be held September 28 ... . The Company also announced the innovative ... overall quality in clinical trials acquired earlier this year, ...
Breaking Biology Technology:In Silico Drug Discovery Conference Announces Speakers and Topics 2In Silico Drug Discovery Conference Announces Speakers and Topics 3In Silico Drug Discovery Conference Announces Speakers and Topics 4In Silico Drug Discovery Conference Announces Speakers and Topics 5In Silico Drug Discovery Conference Announces Speakers and Topics 6In Silico Drug Discovery Conference Announces Speakers and Topics 7Shimadzu’s New Nexera-e Two Dimensional Comprehensive Liquid Chromatograph Empowers Laboratories to Separate Even the Most Complex Mixtures 2Growing Demand for Eco-Friendly Products Drives the Global Biodegradable Polymers Market, According to New Report by Global Industry Analysts, Inc. 2Growing Demand for Eco-Friendly Products Drives the Global Biodegradable Polymers Market, According to New Report by Global Industry Analysts, Inc. 3BioClinica to Present at 20th Annual SCDM Conference 2BioClinica to Present at 20th Annual SCDM Conference 3
... ON ALS CLINICALS AND DRUG DEVELOPMENT, ROCKVILLE, ... (Amex: CUR ) announced that Dr. Thomas ... President, Research. He will be,working with Dr. Karl ... the company,s upcoming clinical trial for ALS,(Amytrophic Lateral ...
... Symbol: MS, EDMONTON, July 30 /PRNewswire-FirstCall/ - BioMS ... of multiple sclerosis (MS), today,announced that Mr. Kevin Giese, ... "Focus on Healthcare Conference" in New York., ... WHERE: The Millennium Broadway Hotel, New York ...
... receives custom orders from leading semiconductor manufacturers, officially putting revenue ... ... Seattle, WA (PRWEB) July 30, 2008 -- Carbon Nanoprobes, Inc ... welcomes its first revenue from two major semiconductor manufacturers. Contracts ...
Cached Biology Technology:Neuralstem Fills Key Product Development Position 2BioMS Medical to present at BMO Healthcare Conference 2Startup Nanotech Firm Books First Revenue From Large Chip Makers 2Startup Nanotech Firm Books First Revenue From Large Chip Makers 3
22 x 50 mm; No. 1 thickness range: 0.13 to 0.17 mm, suitable for work in histology, cytology, urinalysis and microbiology, precleaned, store at room temperature ...
Request Info...
... 2.5%,Adenosine ... <0.1%,Cystathionine ... <0.1%,Glutathione ... to 1 mg/ml,(0.26 M to 2.6 mM) Sensitivity: around 0.2 ug/ml ...
See product name for description....
Biology Products: