Navigation Links
Penn team links placental marker of prenatal stress to brain mitochondrial dysfunction
Date:6/18/2014

When a woman experiences a stressful event early in pregnancy, the risk of her child developing autism spectrum disorders or schizophrenia increases. Yet how maternal stress is transmitted to the brain of the developing fetus, leading to these problems in neurodevelopment, is poorly understood.

New findings by University of Pennsylvania School of Veterinary Medicine scientists suggest that an enzyme found in the placenta is likely playing an important role. This enzyme, O-linked-N-acetylglucosamine transferase, or OGT, translates maternal stress into a reprogramming signal for the brain before birth.

"By manipulating this one gene, we were able to recapitulate many aspects of early prenatal stress," said Tracy L. Bale, senior author on the paper and a professor in the Department of Animal Biology at Penn Vet. "OGT seems to be serving a role as the 'canary in the coal mine,' offering a readout of mom's stress to change the baby's developing brain."

Bale also holds an appointment in the Department of Psychiatry in Penn's Perelman School of Medicine. Her co-author is postdoctoral researcher Christopher L. Howerton. The paper was published online in PNAS this week.

OGT is known to play a role in gene expression through chromatin remodeling, a process that makes some genes more or less available to be converted into proteins. In a study published last year in PNAS, Bale's lab found that placentas from male mice pups had lower levels of OGT than those from female pups, and placentas from mothers that had been exposed to stress early in gestation had lower overall levels of OGT than placentas from the mothers' unstressed counterparts.

"People think that the placenta only serves to promote blood flow between a mom and her baby, but that's really not all it's doing," Bale said. "It's a very dynamic endocrine tissue and it's sex-specific, and we've shown that tampering with it can dramatically affect a
'/>"/>

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Incisive research links teeth with diet
2. New lab mice cut search for genetic links to disease by more than a decade
3. Geographic information systems demonstrate links between health and location
4. Desert to Rainforest global classroom links future teachers, classrooms in Phoenix and Panama
5. 50 years of bird poop links DDT with changing bird menus
6. New study links air pollution and early death in the UK
7. Fossil egg discovered in Lleida (Spain) links dinosaurs to modern birds
8. Research links extreme summer heat events to global warming
9. 10 new diabetes gene links offer picture of biology underlying disease
10. Researchers study links between conflict and fisheries in East Africa
11. 3 new genetic links to colorectal cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn team links placental marker of prenatal stress to brain mitochondrial dysfunction
(Date:12/19/2014)... Research and Markets ( http://www.researchandmarkets.com/research/8kmfcn/iphone_5s ) has ... Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report" ... http://photos.prnewswire.com/prnh/20130307/600769 Following the acquisition of ... feature with the iPhone 5S. It is currently the ...
(Date:12/19/2014)... MOUNTAIN VIEW, Calif. , Dec. 18, 2014  23andMe, Inc., ... a study that pinpoints fine-scale differences in genetic ancestry of ... Since immigrants first arrived more than four hundred ... served as a meeting place for peoples from different continents. ...
(Date:12/17/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ) ... S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis" ... http://photos.prnewswire.com/prnh/20130307/600769 Based on a totally ... for the first time a fingerprint sensor in its ...
Breaking Biology News(10 mins):iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 223andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2
... hydraulic system of trees is so finely-tuned that predicted ... to catastrophic failure in many species. A recent paper ... Sciences Amy Zanne finds that those systems in plants ... their safety threshold, making forest ecosystems vulnerable to increasing ...
... hydrophobic. The hydration or formation of water interfaces ... processes: protein folding, membrane formation, transport of proteins across ... It is involved as well in the process of ... get rid of fat with soap. Hydrophobic interfaces although ...
... is a captive bred Sumatran orangutan. He is a ... the help of specially adapted eye tracking equipment they ... the visual brain and improve the lives of captive ... of Nottingham Malaysia Campus (UNMC), has received funding from ...
Cached Biology News:Increasing drought stress challenges vulnerable hydraulic system of plants, GW professor finds 2Illuminating the no-man's land of waters' surface 2Seeing the world through the eyes of an Orangutan 2Seeing the world through the eyes of an Orangutan 3
(Date:1/22/2015)... (PRWEB) January 21, 2015 Cambridge Semantics, the ... technology, today announced that 2014 was a record-breaking year across ... capabilities of the Anzo Smart Data Platform and our Smart ... utilize insights from diverse data which led to record growth ...
(Date:1/22/2015)... California (PRWEB) January 22, 2015 Pipette.com ... Offer to their comprehensive portfolio of Eppendorf products. ... customers to purchase a Centrifuge 5424/5424 R and receive ... of either Eppendorf Research plus or Eppendorf Reference 2 ...
(Date:1/22/2015)... January 22, 2015 Selexis SA, a ... Research Cell Banks (RCBs) used for drug discovery to ... Banks will include Next-Generation Sequencing (NGS) data ... de-risks biologic manufacturing by ensuring the integrity of the ...
(Date:1/22/2015)... , Jan. 22. 2015  Varian Medical Systems (NYSE: ... been honored for its commitment to sustainability with inclusion on ... is the highest ranked healthcare equipment company among the Corporate ... the World Economic Forum at Davos, Switzerland ...
Breaking Biology Technology:Cambridge Semantics Announces Record Results for 2014 2Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2Varian Honored Among World's 100 Most Sustainable Corporations 2
... , , SAN DIEGO, July ... reported that it has received a letter from the NYSE Amex ... company,s exchange listing compliance. , , (Logo: http://www.newscom.com/cgi-bin/prnh/20051018/CARDIUMLOGO ... Amex, Cardium was informed that based upon a review of publicly ...
... NES-ZIONA, Israel, July 27, PROLOR Biotech, Inc. (OTC ... entered into an evaluation and option agreement with Yeda Research and ... Weizmann Institute of Science . Under the terms of ... license to develop a number of peptide drug candidates, including an ...
... , , ANAHEIM, Calif., July 27 ... see our company providing the technological platform for a wide range ... the position of President/CEO from the Board of Directors of Sechrist ... over 30 years and maintains the largest installed base of single-place ...
Cached Biology Technology:Cardium Regains Listing Compliance with NYSE Amex 2Cardium Regains Listing Compliance with NYSE Amex 3PROLOR Biotech Acquires License Option from Yeda for Development of Long-Acting Anti-Obesity Drug 2PROLOR Biotech Acquires License Option from Yeda for Development of Long-Acting Anti-Obesity Drug 3Sechrist Industries, World Leader in Hyperbaric Chambers, Announces Edward Pulwer as President/CEO 2
...
... sample is a complex protein sample, ... when used with ReadyPrep 2-D starter ... sample can be used as a ... and protocol before using more difficult ...
... Each kit contains sufficient materials for 1,464 array ... Nitrocellulose Membrane: 4 each , Blocker BSA in PBS ... , BupH Phosphate Buffered Saline: 8 packs , 10% ... Pico Luminol Enhancer: 2 x 25 ml , SuperSignal ...
... new HydroFlex platform provides excellent performance, ... of 96-well format applications, including washing ... arrays, and vacuum filtration-to-waste, such as ... on-line control features set new standards ...
Biology Products: