Navigation Links
Penn team elucidates evolution of bitter taste sensitivity
Date:11/11/2013

R16 mutations.

The taste testing shows that the mutations in TAS2R16 had functional significance for the bitter taste perception system," Breslin said. "In this case, the mutation caused a gain of taste function.

When the researchers "mapped" individuals' genetic profiles onto their tasting ability, they found a strong correlation between one of the 15 variants and an increased sensitivity to salicin. The cell-based analysis offered an explanation for this sensitivity: cells with this genetic mutation had nearly twice as many receptors for salicin on their membranes as did cells with other forms of the TAS2R16 gene.

On a population level, the researchers found that the "high-sensitivity" variant for salicin was more prevalent in individuals from East Africa than in those from West Central or Central Africa, and non-Africans possessed only the "high-sensitivity" version of the gene. What's more, in East Africans this high-sensitivity variant, which arose roughly 1.1 million years ago, showed signs of being under a force of natural selection in humans, suggesting it conferred an evolutionary advantage at some point during our past.

"That's another sign that this variant must be tremendously important for human survival because it evolved in our human ancestors so long ago and carried over to us," Campbell said.

The geographic structure of TAS2R16 variants contrasts with the previous work on TAS2R38, variants of which did not appear to fall into any clear geographic pattern. These differences between two genes that both relate to bitter taste perception offer more support to the idea that taste was not the only force driving the evolution of this gene.

"The types of populations we're studying are diverse and they have diverse diets," Tishkoff said, "suggesting that there is likely something else going on here. By getting a handle on how much variation is in these populations, where it is located and what are
'/>"/>

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Fast-mutating DNA sequences shape early development; guided evolution of uniquely human traits
2. Targeting evolution: Could this be the next strategy to stop superbugs?
3. Alfred Russel Wallace: Co-founder of the theory of biological evolution
4. Climate change and coevolution: Weve done the math
5. Grazers and pollinators shape plant evolution
6. Evolutionary medicine of skin cancer risk among Europeans
7. Recent highlights in Molecular Biology and Evolution
8. Fear of holes may stem from evolutionary survival response
9. Penn biologists show that generosity leads to evolutionary success
10. Biometrics Can Revolutionise Mobile Payment Security, says Frost & Sullivan
11. Family matters: Evolutionary relationships among species of magic mushrooms shed light on fungi
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn team elucidates evolution of bitter taste sensitivity
(Date:6/24/2015)... 2015 Research and ... the "Huawei Ascend Mate 7 Fingerprint Sensor ... offering. Huawei,s technological choice for the ... than Apple,s and Samsung,s one. The Ascend Mate ... Fingerprint Cards, a main actor in capacitive sensing ...
(Date:6/23/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/vq2k2f/bodyworn ... "Body-Worn Temperature Sensors Market - Global Industry Analysis, ... 2020" report to their offering. ... body-worn temperature sensors market. The global body-worn temperature ... of types, care setting, patient demographic, applications and ...
(Date:6/18/2015)... , June 18, 2015 This report ... Million by the following Product Segments, which includes Immunoassay ... Chemiluminescence Immunoassay Systems, Radio Immunoassay Systems, and Nephelometric Immunoassay ... US, Canada , Japan ... Asia-Pacific , Latin America , ...
Breaking Biology News(10 mins):Huawei Ascend Mate 7 Fingerprint Sensor - Reverse Costing Analysis 2Body-Worn Temperature Sensors Market - Global Industry Analysis 2Global Immunoassay Systems Market 2Global Immunoassay Systems Market 3Global Immunoassay Systems Market 4Global Immunoassay Systems Market 5Global Immunoassay Systems Market 6Global Immunoassay Systems Market 7Global Immunoassay Systems Market 8Global Immunoassay Systems Market 9Global Immunoassay Systems Market 10Global Immunoassay Systems Market 11Global Immunoassay Systems Market 12Global Immunoassay Systems Market 13Global Immunoassay Systems Market 14Global Immunoassay Systems Market 15Global Immunoassay Systems Market 16Global Immunoassay Systems Market 17Global Immunoassay Systems Market 18Global Immunoassay Systems Market 19Global Immunoassay Systems Market 20Global Immunoassay Systems Market 21Global Immunoassay Systems Market 22Global Immunoassay Systems Market 23Global Immunoassay Systems Market 24Global Immunoassay Systems Market 25Global Immunoassay Systems Market 26Global Immunoassay Systems Market 27Global Immunoassay Systems Market 28Global Immunoassay Systems Market 29
... discovered a super-charged methane seep in the ocean off New ... in much more methane escaping from the ocean floor into ... gas 23 times more potent than carbon dioxide at warming ... water, the scientists say. Thus it will not make it ...
... patients, it,s not the primary tumor that is deadly, but ... tumor to secondary locations throughout the body that is the ... is how to stop or fight metastasis. Previous ... molecular change when they leave the primary tumor a ...
... under a third of young Swiss men prefer beer when ... their alcohol consumption in the form of the beverage. Far ... between the preference for particular alcoholic beverages and a riskier ... from the Institute of Social and Preventive Medicine at the ...
Cached Biology News:Study finds novel worm community affecting methane release in ocean 2Study finds novel worm community affecting methane release in ocean 3New evidence that cancer cells change while moving throughout body 2Young beer-drinkers binge-drink more frequently 2
(Date:7/2/2015)... ... July 02, 2015 , ... In’Tech Medical SAS ... in Orthopedics, announced today the acquisition of Turner Medical, Inc ., thus ... surgical instruments to the Spine Industry. The acquisition of Turner Medical ideally supplements ...
(Date:7/1/2015)... Colo. and BANGALORE, India ... global genomic profiling company that uses next generation sequencing ... of Scott A. Storrer as chief executive ... CEO, he will be responsible for all strategy, business ... Chandru , who has served as Strand,s chairman and ...
(Date:7/1/2015)... July 1, 2015 InferMed ... will ... evidence-based clinical s olutions suite   ... medical information products and services, announced today the acquisition of  ... support (CDS) technology company. InferMed,s Arezzo technology supports ...
(Date:6/30/2015)... ... June 30, 2015 , ... ... to take part in the first half of “Integrative Biotechnology,” an applied biotechnology ... established in summer 2014, this course combines students from both universities and is ...
Breaking Biology Technology:In'Tech Medical Acquires Turner Medical to Become a World Leader in Orthopedic Contract-Manufacturing 2In'Tech Medical Acquires Turner Medical to Become a World Leader in Orthopedic Contract-Manufacturing 3Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 2Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 3Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 2Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 3Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 4Rivier University and Beijing City University Academic and Cultural Exchanges Begin 2
... Firms Recommend Pharmion ... merger with Celgene Special Meeting ... Corp. Urges All Shareholders to Vote FOR the Proposed Merger, ... ) today announced that Institutional Shareholder Services,(ISS) has recommended that ...
... and Vaccine Immunology, ANN ARBOR, Mich., Feb. 26 ... have demonstrated their nasally,delivered vaccinia vaccine can protect animals ... without the safety risks of,current vaccines for smallpox. Vaccinia ... it., The new vaccine confers a high level ...
... Switzerland, February 26 Arpida Ltd.,(SWX: ARPN) today reported ... for intravenous iclaprim in its first indication,complicated Skin and ... few weeks., Arpida has agreed with the U.S. ... a rolling process. Using a ,rolling NDA, allows modules,within ...
Cached Biology Technology:ISS Recommends Pharmion Shareholders Vote for Merger With Celgene 2ISS Recommends Pharmion Shareholders Vote for Merger With Celgene 3Nasal Vaccine for Smallpox Confers High Levels of Immunity Without Safety Risks 2Nasal Vaccine for Smallpox Confers High Levels of Immunity Without Safety Risks 3Arpida Provides Update on Progress of New Drug Application for Intravenous Iclaprim 2Arpida Provides Update on Progress of New Drug Application for Intravenous Iclaprim 3
2,4-Dinitrophenyl hapten is conjugated to BSA (Bovine Serum Albumin) protein through lysine....
4-Hydroxy-3-iodo-5-nitrophenylacetyl hapten is conjugated to BSA protein through lysine by amide bonds....
Amino Acid Analysis is performed using ion-exchange separation of the amino acids from acid hydrolysates, followed by ninhydrin detection. Typical quantities required are 0.1 to 0.5 mg, depending on...
2,4,6-Trinitrophenyl hapten is conjugated to Bovine Serum Albumin protein through lysine by amide bonds....
Biology Products: