Navigation Links
Penn team elucidates evolution of bitter taste sensitivity
Date:11/11/2013

er Penn researchers collaborated with Paul Breslin of Rutgers University and Monell Chemical Senses Center, as well as scientists from Addis Ababa University, France's Muse de L'Homme, Integral Molecular Inc., the Kenya Medical Research Institutes, Cameroon's Ministry of Scientific Research and Innovation, Tanzania's Muhimbili University of Health and Allied Sciences and the National institute on Deafness and Other Communication Disorders.

The work builds on a previous study by the group, which explored the evolutionary history of a gene called TAS2R38, responsible for the ability to perceive the bitter tasting compound PTC. In that research, published in Molecular Biology and Evolution in 2011, the geneticists discovered that something other than taste perception must have driven the selection of that gene.

The current work examines the related gene TAS2R16, which codes for a molecular receptor that binds salicin. Salicin is a chemical found naturally in willow bark, the source of aspirin. It acts as an anti-inflammatory but in large doses can be toxic. It is also found in many nuts, fruits and vegetables.

To understand the patterns of variation at TAS2R16 in humans globally, the researchers collected DNA from 595 people in 74 populations across Africa with diverse lifestyles, such as pastoralism, hunting-gathering and agriculture. They sequenced the stretch of DNA encompassing the TAS2R16 gene in all of these individuals and also examined previously collected DNA from 94 non-Africans from the Middle East, Europe, East Asia and the Americas and found 15 variants total, most of which were only found in Africa.

In addition, the researchers asked 296 of the Africans sampled to perform "taste tests" of progressively more concentrated solutions of salicin and report when they could detect a bitter taste. The team also performed a cellular analysis, led by Integral Molecular scientists, to see the molecular effects of different TAS2
'/>"/>

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Fast-mutating DNA sequences shape early development; guided evolution of uniquely human traits
2. Targeting evolution: Could this be the next strategy to stop superbugs?
3. Alfred Russel Wallace: Co-founder of the theory of biological evolution
4. Climate change and coevolution: Weve done the math
5. Grazers and pollinators shape plant evolution
6. Evolutionary medicine of skin cancer risk among Europeans
7. Recent highlights in Molecular Biology and Evolution
8. Fear of holes may stem from evolutionary survival response
9. Penn biologists show that generosity leads to evolutionary success
10. Biometrics Can Revolutionise Mobile Payment Security, says Frost & Sullivan
11. Family matters: Evolutionary relationships among species of magic mushrooms shed light on fungi
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn team elucidates evolution of bitter taste sensitivity
(Date:7/27/2015)... 2015   Zynx Health ™, the market ... solutions, today announced that its ZynxCarebook ™ ... Android smartphones and tablets. With this expansion, care ... use ZynxCarebook to securely exchange messages and share ... transitions to other care settings, and improve clinical ...
(Date:7/21/2015)... Today, ZTE announced its Android smartphone Axon, featuring FPC,s ... in 2015 that relate to sales of FPC1025 for this smartphone ... MSEK for 2015. Jörgen Lantto, CEO of FPC, comments: ... China and we are proud that ... Axon , its first smartphone ...
(Date:7/20/2015)... 2015  Acuity Market Intelligence,s latest research "The ... Commerce and Privacy" forecasts that between 2014 and ... be downloaded to smart mobile devices by 2.2 ... is projected to generate more than $67.9 billion ... forecast period.    "Biometrics is at ...
Breaking Biology News(10 mins):Zynx Health Adds Android Device Support to ZynxCarebook Solution 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 3FPC's Touch Fingerprint Sensor FPC1025 in ZTE's Smartphone Axon 2Biometrics on Smart Mobile Devices to Redefine Digital Identity with 12.9 Billion Biometric App Downloads between 2014 and 2020 2
... Current standards for classifying foods as "whole grain" are ... new study by Harvard School of Public Health (HSPH) ... the Whole Grain Stamp, actually identified grain products that ... without the Stamp. The researchers urge adoption of a ...
... hybrid fish in his time as a graduate student in ... helped him create one of the most comprehensive snapshots of ... in evolutionary biology. "We can see a surprisingly complex ... species," said Martin, who with Professor Peter Wainwright published a ...
... scientist with Texas A&M AgriLife Research has begun work on ... lipid which can then be used to make more fuel. ... the U.S. Department of Energy, could help solve the challenge ... Yuan of College Station, AgriLife Research plant pathologist and lead ...
Cached Biology News:Foods identified as 'whole grain' not always healthy 2Foods identified as 'whole grain' not always healthy 3A snapshot of pupfish evolution in action 2AgriLife Research gets grant to crack biofuel production waste issue 2
(Date:7/30/2015)... , July 30, 2015   Aratana ... pet therapeutics company focused on the licensing, development ... animals, today announced that its strategic partner VetStem ... dose confirmation study of AT-016, an adipose-derived allogeneic ... the treatment of osteoarthritis pain in dogs. ...
(Date:7/30/2015)... 2015  With over 60,000 customers across the globe, ISN improves the efficiency and ... with more than 60,000 safe and reliable contractors in over 80 countries. ... ... Over 60,000 Worldwide Customers ... Headquartered in Dallas, TX , ISN has ...
(Date:7/30/2015)... LOUIS, July 30, 2015 HIGHLIGHTS:Q2 ... in 2014) , Reported sales were $697 million ... 2014.  Sales grew organically by 8%, and changes in ... acquisitions increased sales by 1%. , By business ... in Applied and 11% in SAFC Commercial. , ...
(Date:7/30/2015)... ... ... part of its 2015 growth plan and as a follow up to the recently announced ... Laboratories is pleased to announce that it has begun construction on a new Microbiological Laboratory. ... be strictly dedicated to basic USP 51, USP 61, and USP 62 testing specific to ...
Breaking Biology Technology:Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 2Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 3Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 4Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 5ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 2Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 3Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 4Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 5Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 6Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 7Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 8Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 9Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 10Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 11Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 12Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 13Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 14Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 15Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 16Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 17Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 18Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 19Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 20Whitehouse Labs Formally Announces Plans to Open a Microbiological Laboratory 2
... Nanogea Adds Drs. ... ... Nanogea, a nano-biotech company focused on commercializing the industry,s most sensitive single molecular detection platform, ... have joined its scientific advisory board. , , ,Dr. Caskey is a prominent medical geneticist ...
... Oct. 8 /PRNewswire-FirstCall/ - Medicago Inc. (TSX-V: MDG), ... and affordable vaccines based on proprietary manufacturing technologies ... has been awarded a proof of concept contract ... Command laboratory specifically the Edgewood Chemical Biological Center ...
... ... work based on data collected at the U.S. Department of Energy,s (DOE) Argonne National Laboratory. ... Argonne, Ill. (Vocus) ... award-winning work based on data collected at the U.S. Department of Energy,s (DOE) Argonne National ...
Cached Biology Technology:Nanogea Announces New Scientific Advisory Board Members 2Nanogea Announces New Scientific Advisory Board Members 3Medicago awarded contract by the U.S. Army to explore applications of its plant-based technology in renewable energy 2Argonne's Advanced Photon Source Lit the Way to Chemistry Nobel 2Argonne's Advanced Photon Source Lit the Way to Chemistry Nobel 3
Rabbit polyclonal to NIRF ( Abpromise for all tested applications). Antigen: Synthetic peptide derived from residues 186-235 of human NIRF. Entrez Gene ID: 115426 Swiss Protein ID: Q96PU...
...
...
...
Biology Products: