Navigation Links
Penn study shows 2-sided immune cell could be harnessed to shrink tumors
Date:10/28/2010

PHILADELPHIA - A recently identified immune cell that directs other cells to fight infection plays a critical role in regulating the immune system in both health and disease. Researchers from the University of Pennsylvania School of Medicine have discovered how a stimulatory molecule and a protein found on the membrane of another immune cell make T helper 17 cells multi-taskers of sorts. Th17 cells protect the body against infection and cancer, but are also culprits in some autoimmune diseases and out-of-control, cancerous cell growth.

This new understanding that Th17 cells manage to play both sides of the fence suggests that targeting or inhibiting the involved protein pathways might be a new way to treat cancer, chronic infection, and some autoimmune diseases. Previous studies have linked excessive amounts of Th17 cells in the body to such autoimmune diseases as multiple sclerosis, psoriasis, rheumatoid arthritis, and Crohn's disease.

First author and postdoctoral fellow Chrystal Paulos PhD; senior author Carl June, MD, professor of Pathology and Laboratory Medicine, and colleagues have found that a protein called inducible costimulator (ICOS) is necessary for the growth and function of human Th17 cells, while CD28, a transmembrane protein on CD4 cells, stops the ICOS signal. What's more, human Th17 stimulated with ICOS shrank human tumors implanted in a mouse model faster than those stimulated with CD28. The findings appear in this week's Science Translational Medicine. June is also the Program Director of Translational Research for the Abramson Family Cancer Research Institute at Penn.

These findings were surprising to the researchers given that CD28 has historically been used by investigators to study and expand human Th17 cells. The new data on Th17 cells raises the possibility that the full inflammatory potential of human Th17 cells had not been fully reflected by previous lab studies.

To move this knowledge closer to the clinic, the team also demonstrated that Th17 cells cannot only be expanded to large numbers, but could also be maintained by stimulating them with ICOS proteins. Th17 polarizing cytokines have previously been shown to support Th17 cells from nave CD4 cells but this is the first demonstration that the ICOS costimulatory molecule used to expand the Th17 cells is important.

Tilting the balance between spurring and suppressing the growth of Th17 cells may be a key to tailoring immunotherapy, a form of cancer treatment. Adoptive transfer of tumor-specific cells expanded with ICOS and polarized to a Th17 cell type might further improve treatment.

These basic findings on Th17 cells in both peripheral and cord blood cells has broad implications, providing the basis of a new human cancer treatment protocol. T-cell-based therapies that incorporate the ICOS signal are being planned at Penn to treat patients with leukemia.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Related biology news :

1. Texas A&M University becomes key player in global study to save Earths endangered species
2. Study suggests a third of shark and ray species are threatened
3. Study identifies key molecules in multiple myeloma
4. Landenberger Foundation awards grant to Scripps Florida scientist to study HIV
5. Penn study identifies molecular guardian of cells RNA
6. LSUHSC study IDs proteins regulating water retention in salt-sensitive hypertension
7. Offshore wind a mixed bag: University of Maryland study
8. Modeling study identifies characteristics of high elk-use areas in western Oregon, Washington
9. Universities receive grants to study climate change decisions
10. Center to study effects of plastics chemicals on childrens health
11. Study of tiny magnets may advance their use in microelectronics
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn study shows 2-sided immune cell could be harnessed to shrink tumors
(Date:3/15/2016)... -- --> --> According ... "Digital Door Lock Systems Market - Global Industry Analysis, Size, ... digital door lock systems market in terms of revenue was ... to grow at a CAGR of 31.8% during the period ... (MSMEs) across the world and high industrial activity driving inclusive ...
(Date:3/11/2016)... --> --> ... Recognition Market by Technology (Pattern Recognition), by Component (Hardware, ... Type (On-Premises and Cloud), by Industry Vertical and by ... the global market is expected to grow from USD ... 2020, at a CAGR of 19.1%. , ...
(Date:3/9/2016)... BEACH GARDENS, Fla. , March 9, 2016 ... identity management authentication and enrollment solutions, today announced ... DigitalPersona ® Altus multi-factor authentication ... IT and InfoSec managers to step-up security where ... Washington, DC . ...
Breaking Biology News(10 mins):
(Date:5/23/2016)... ... May 23, 2016 , ... RoviSys, a leading ... in Aurora, Ohio, has broken ground on a new building in Holly Springs, ... area, this new location solidifies a commitment to business in the region. The ...
(Date:5/20/2016)... San Diego, CA (PRWEB) , ... May 20, 2016 , ... ... announce that 10 of its most experienced veterinary clients have treated over 100 of ... this cutting edge technology to provide the highest level of care for their patients. ...
(Date:5/20/2016)... ... ... The recent recall by Costco and Trader Joes of 47 million pounds of ... demonstrates the need for faster and more cost effective bio-threat detection to ensure food ... , PathSensor’s latest solution uses a biosensor technology called CANARY®. CANARY®, an ...
(Date:5/19/2016)... There is no saying when ... relentless pressures in pricing and lack in consumer confidence. ... though - numerous opportunities are up for grabs but ... presents four names in this sector: Portola Pharmaceuticals Inc. ... VTAE ), Anthera Pharmaceuticals Inc. (NASDAQ: ...
Breaking Biology Technology: