Navigation Links
Penn researchers shine the light of venus to learn how the herpes virus invades cells
Date:12/13/2007

PHILADELPHIA - University of Pennsylvania researchers have uncovered an important step in how herpes simplex virus, HSV-1, uses cooperating proteins found on its outer coat to gain entry into healthy cells and infect them. Further, the studys authors say, they have demonstrated the effectiveness of monitoring these protein interactions using biomolecular complementation.

The findings, published in the Proceedings of the National Academy of Sciences, provide a better understanding of the mechanism that viruses use to conquer healthy cells.

Beginning with the knowledge that HSV-1 glycoprotein gD binds to cell receptors in a healthy cell to begin virus-cell fusion, researchers questioned how other proteins combined or cooperated on the attack. They tagged additional HSV-1 proteins with a fluorescent marker to witness the complex battle, thus demonstrating that gD somehow signals to three other herpes proteins -- gB, gH and gL -- to swing into action, continuing fusion and ultimately releasing the viral genome into the cell. Once in the cell, the viral genome takes over and directs the cell to make more virus.

Watching these proteins interact tells us a lot about HSV and other herpes viruses and how they attack the body, Roselyn Eisenberg, professor of microbiology in Penns School of Veterinary Medicine, said. The first thing this virus does when it finds a cell is fool the cell into thinking the virus is a welcome guest when it is actually a dangerous intruder. But getting in is not easy. It takes four viral proteins to do it, and they must cooperate with each other in ways that we are only beginning to understand.

Monitoring the interactions required a novel technique. Researchers assumed in their hypothesis that these proteins had to physically interact with each other but could not demonstrate the split-second interaction. Penn researchers hypothesized that the encounter might be too brief and decided to look for ways to freeze
'/>"/>

Contact: Jordan Reese
jreese@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/4/2015)... ) today reported financial and operating results for the second quarter ... quarter contract revenue of $ 85.2 million, a ... of 26 % , Second quarter adjusted ... royalties in the current quarter , Operating cash ... to present another strong financial quarter, with all our divisions achieving ...
(Date:7/31/2015)... -- Den 10. internationale konference om Genomik (ICG-10, ... 25. oktober i Shenzhen , Kina. ... år. Siden starten i 2006 er ICB blevet en ... er en af de mest dynamiske, entusiastiske og sjove ... gennembrud og fremskridt inden for ,omik,-forskning, som yderligere vil ...
(Date:7/31/2015)... SHENZHEN, China , 31 de julho de 2015 ... Genômica (ICG-10, www.icg-10.org ) será realizada pela BGI de ... China . A conferência está ... inauguração em 2006, a ICG se tornou uma das ... e um dos encontros científicos mais dinâmicos, entusiastas e ...
Breaking Biology News(10 mins):AMRI Announces Second Quarter 2015 Results 2AMRI Announces Second Quarter 2015 Results 3AMRI Announces Second Quarter 2015 Results 4AMRI Announces Second Quarter 2015 Results 5AMRI Announces Second Quarter 2015 Results 6AMRI Announces Second Quarter 2015 Results 7AMRI Announces Second Quarter 2015 Results 8AMRI Announces Second Quarter 2015 Results 9AMRI Announces Second Quarter 2015 Results 10AMRI Announces Second Quarter 2015 Results 11AMRI Announces Second Quarter 2015 Results 12AMRI Announces Second Quarter 2015 Results 13AMRI Announces Second Quarter 2015 Results 14AMRI Announces Second Quarter 2015 Results 15AMRI Announces Second Quarter 2015 Results 16AMRI Announces Second Quarter 2015 Results 17AMRI Announces Second Quarter 2015 Results 18AMRI Announces Second Quarter 2015 Results 19AMRI Announces Second Quarter 2015 Results 20AMRI Announces Second Quarter 2015 Results 21AMRI Announces Second Quarter 2015 Results 22AMRI Announces Second Quarter 2015 Results 23AMRI Announces Second Quarter 2015 Results 24Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3
... depends on the nutritional value and yield of staple food ... an increase in toxic compounds, a decrease in protein content ... 2 and drought conditions. The research, to ... at the Society for Experimental Biology Annual Meeting in Glasgow, ...
... of survival is now better understood. For the first ... Berkeley National Laboratory observed the chemical changes in individual ... kill them. The team tracked the chemical changes ... normally can only exist in an oxygen-free environment. They ...
... Paths" is a response to confusion and uncertainty on ... and electricity -- as a prominent factor in meeting ... joining forces to seek resolution of issues related to ... opportunities to integrate biomass production with food crops and ...
Cached Biology News:Scientists track chemical changes in cells as they endure extreme conditions 2Scientists track chemical changes in cells as they endure extreme conditions 3Sustainable bioenergy project has global launch 2
(Date:9/1/2015)... ... September 01, 2015 , ... GenoCAD, a leading provider of ... of its flagship DNA design platform, which has been enhanced to boost user ... genetic parts, which in turn can be recombined using specific sets of rules ...
(Date:8/31/2015)... Milpitas, Calif. (PRWEB) , ... August 31, 2015 ... ... earlier this year to bring together supply chain risk management and resiliency practitioners ... collaborate, develop and share best practices, and be recognized for their innovations and ...
(Date:8/31/2015)... ... August 31, 2015 , ... ... because of its properties such as low carbon footprints and compostability. These properties ... of petroleum based plastics. On the basis of applications, the market for biodegradable ...
(Date:8/31/2015)... , Aug. 31, 2015 Research and ... the "Argentina Biomedical Sensors Market - Growth, Trends ... The Argentina Biomedical Sensors market is estimated ... 1.17% over the period 2014-2020 The near ... the genetic formulation of each individual. These sensors can ...
Breaking Biology Technology:GenoCAD Releases Combinatorial Design Tool to Optimize Protein Expression and Streamline DNA Synthesis Orders 2Global Supply Chain Resiliency Council Announces Incorporation and Web Site Launch 2Global Supply Chain Resiliency Council Announces Incorporation and Web Site Launch 3Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 2Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 3Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 4Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 5Argentina Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts 2014-2020 2
... . - GE Healthcare and the Vancouver ... million agreement under which the authority would purchase 48 new ... advanced ultrasound technologies and establish new clinical workflow and administrative ... board, said the agreement will result in more precise diagnosis ...
... a series of articles on developing start-up companies in the ... business taxes. , , Madison, Wis. ... begin hiring workers. As discussed in the previous article, you ... Security and Medicare taxes, and unemployment taxes ...
... has added so much complexity to information technology systems ... ,That according to John Swainson, president and CEO of ... address at the 2007 Fusion CEO-CIO Symposium . ... relationship between business and information technology. , ,That relationship ...
Cached Biology Technology:Early Stage 7, Part I: Just what is an employee? 2Early Stage 7, Part I: Just what is an employee? 3Early Stage 7, Part I: Just what is an employee? 4Early Stage 7, Part I: Just what is an employee? 5Fusion 2007: CA chief says IT complexity raises risk 2Fusion 2007: CA chief says IT complexity raises risk 3
... developed specifically for pulsed field separations of DNA larger than 2, ... megabase pairs. This agarose has the highest gel ... ... Chromosomal Grade, ...
... this enzyme exists predominantly as XDH which ... a critical plasma antioxidant. During ischemia, ... radical producing XO by oxidation of essential ... cleavage of the amino-terminus. AO has ...
Rabbit Anti-Human Janus Kinase 2 (JAK2 Polyclonal Antibody Family: Protein Kinase Sub-Family: TYK2/JAK Applications: ELISA, Western Blot...
... 2 (VMAT2). An antibody made to the ... at ~55 kDa in postnuclear supernatants of ... wild type cells (2). Some additional bands, ... also detected and remain unaffected by the ...
Biology Products: