Navigation Links
Penn researchers improve living tissues with 3-D printed vascular networks made from sugar
Date:7/1/2012

ding blocks are also typically added and dissolved into nutrient media that help cells grow.

"We tested many different sugar formulations until we were able to optimize all of these characteristics together," Miller said. "Since there's no single type of gel that's going to be optimal for every kind of engineered tissue, we also wanted to develop a sugar formula that would be broadly compatible with any cell type or water-based gel."

The formula they settled on a combination of sucrose and glucose along with dextran for structural reinforcement is printed with a RepRap, an open-source 3D printer with a custom-designed extruder and controlling software. An important step in stabilizing the sugar after printing, templates are coated in a thin layer of a degradable polymer derived from corn. This coating allows the sugar template to be dissolved and to flow out of the gel through the channels they create without inhibiting the solidification of the gel or damaging the growing cells nearby. Once the sugar is removed, the researchers start flowing fluid through the vascular architecture and cells begin to receive nutrients and oxygen similar to the exchange that naturally happens in the body.

The whole process is quick and inexpensive, allowing the researchers to switch with ease between computer simulations and physical models of multiple vascular configurations.

"This new platform technology, from the cell's perspective, makes tissue formation a gentle and quick journey," Chen said, "because cells are only exposed to a few minutes of manual pipetting and a single step of being poured into the molds before getting nourished by our vascular network."

The researchers showed that human blood vessel cells injected throughout the vascular networks spontaneously generated new capillary sprouts to increase the network's reach, much in the way blood vessels in the body naturally grow. The team then created gels containing primary
'/>"/>

Contact: Evan Lerner
elerner@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. BUSM researchers identify role of FOXO1 gene in Parkinsons disease
2. How sweet it is: Tomato researchers discover link between ripening, color and taste
3. Researchers discover potential explanation for why a diet high in DHA improves memory
4. Rice researchers develop paintable battery
5. UMass Medical School researchers discover a new role for RNAi
6. Researchers develop new method for analyzing cell function
7. Maths formula leads researchers to source of pollution
8. 7 pharmaceutical companies join academic researchers to speed TB drug discovery
9. Researchers advance biometric security
10. Argonne researchers receive 4 R&D 100 awards
11. Researchers identify need to sample multiple tumor zones in breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn researchers improve living tissues with 3-D printed vascular networks made from sugar
(Date:8/27/2014)... that a single fungal cell or bacterial colony exerts on ... a heavy role in setting up some of the most ... be too much of a stretch to say that plants ... respond to the touch of beneficial fungi, according to a ... at the University of Wisconsin-Madison. , "Many people have ...
(Date:8/27/2014)... mysteries of the human genome was unveiled today in ... detailed comparison yet of how the genomes of the ... research, appearing August 28 in in the journal ... three species, genomes is "read out," and how their ... results add billions of entries to a publicly available ...
(Date:8/27/2014)... have identified a gene that could help scientists engineer ... in the cell membrane of plants that senses changes ... machinery accordingly. , "It,s similar to a thermostat," ... Duke. , The findings, which appear Aug. 28 ... easier to feed the world,s growing population in the ...
Breaking Biology News(10 mins):A touching story: The ancient conversation between plants, fungi and bacteria 2A touching story: The ancient conversation between plants, fungi and bacteria 3Encyclopedia of how genomes function gets much bigger 2Encyclopedia of how genomes function gets much bigger 3Encyclopedia of how genomes function gets much bigger 4Water 'thermostat' could help engineer drought-resistant crops 2
... 27, 2013) A team of Korean ... the neurobehavioral function of six week-old mice ... to treat hypoxic-ischemic brain injury, and found that ... through exercise-induced fibroblast growth factor 2 (FGF2), a ...
... Researchers from Lund University, Yale University and the University of ... cuckolded males in many species still provide paternal care. When ... successful. In many species males put a lot of ... At first glance this makes no sense at all because ...
... Since its introduction fifty or so years ago, thermography has ... lameness in horses. The method is fast and safe ... body surface emits infrared radiation that can be detected by ... use. The camera produces a coloured image that shows ...
Cached Biology News:Environmental enrichment important factor impacting cell transplantation and brain repair 2Environmental enrichment important factor impacting cell transplantation and brain repair 3Why sticking around is sometimes the better choice 2Blowing in the wind: How accurate is thermography of horses' legs? 2
(Date:8/27/2014)... (PRWEB) August 27, 2014 In ... through Lawrence Livermore National Security LLC ... develop and deliver a state-of-the-art laser system for ... (ELI Beamlines), under construction in the Czech Republic. ... the laser system, called the " High repetition-rate ...
(Date:8/27/2014)... 27, 2014 The Global and China ... on the current state of the Trifluoroacetic Acid industry ... basic overview of the industry, including definitions, applications and ... market analysis are provided with a focus on history, ... comparison between the international and Chinese situation is also ...
(Date:8/27/2014)... Aug. 27, 2014  A novel biomarker for ... physicians better identify early-stage disease, when treatment can ... to a new study in The Journal of ... DGX ) and other institutions found ... outperformed conventional antibody-serum testing, including rheumatoid factor (RF) ...
(Date:8/27/2014)... 27, 2014 Flagship Biosciences LLC, a ... to the pharmaceutical and medical device industries, has announced ... fast growing company has consolidated its histology and tissue ... to Westminster, CO, just north of Denver. The ... W. 103rd Ave., Suite 100, Westminster, CO 80021 , ...
Breaking Biology Technology:LLNL Synchs up with ELI Beamlines on Timing System 2LLNL Synchs up with ELI Beamlines on Timing System 3Trifluoroacetic Acid Industry (Asia, Europe, North America, ROW) Analysis Report Now Available at ReportsnReports.com 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 3Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 4Flagship Biosciences Announces Relocation and Expansion 2
... SAN DIEGO, Jan. 26 Amylin Pharmaceuticals, Inc.,(Nasdaq: ... P. Mihalik has been appointed,Senior Vice President, Sales ... more than 30 years of experience across multiple ... management,product launches and brand management. His career has ...
... and BINGHAM FARMS, Mich., Jan. 26 WellCentive, ... by my1HIE(sm) (My,One Health Information Exchange) as its ... Through the use of WellCentive Registry, ... providers in Southeast Michigan will be better able ...
... Sirion Therapeutics, Inc., a privately held ophthalmic-focused biopharmaceutical ... for ganciclovir ophthalmic gel, 0.15%, has been accepted for ... Sirion Therapeutics is seeking approval for ganciclovir as a ... the herpes simplex virus. The FDA has issued an ...
Cached Biology Technology:Amylin Pharmaceuticals Appoints Vincent Mihalik Senior Vice President, Sales and Marketing and Chief Commercial Officer 2Amylin Pharmaceuticals Appoints Vincent Mihalik Senior Vice President, Sales and Marketing and Chief Commercial Officer 3my1HIE(sm) Implements WellCentive Registry 2my1HIE(sm) Implements WellCentive Registry 3Sirion Therapeutics New Drug Application for Ganciclovir is Accepted for Review by the FDA for the Treatment of Ocular Herpes 2Sirion Therapeutics New Drug Application for Ganciclovir is Accepted for Review by the FDA for the Treatment of Ocular Herpes 3
S-100A10 (H-80)...
Vapor phase risers are available in various heights to accomodate a variety of inventory solutions. Risers are used to creat a false bottom in which the tanks platform rests and Liquid nitrogen is s...
... single-stranded DNA and RNA endonucleolytically to ... (DNA:DNA, DNA:RNA or RNA:RNA) are resistant ... concentrations of enzyme (1). The enzyme ... from double-stranded DNA (2), for selective ...
SP6 RNA Polymerase, 50 l, 20 U/l ,Cap Scribe Buffer, 100 l, 5x conc....
Biology Products: