Navigation Links
Penn researchers improve living tissues with 3-D printed vascular networks made from sugar
Date:7/1/2012

ding blocks are also typically added and dissolved into nutrient media that help cells grow.

"We tested many different sugar formulations until we were able to optimize all of these characteristics together," Miller said. "Since there's no single type of gel that's going to be optimal for every kind of engineered tissue, we also wanted to develop a sugar formula that would be broadly compatible with any cell type or water-based gel."

The formula they settled on a combination of sucrose and glucose along with dextran for structural reinforcement is printed with a RepRap, an open-source 3D printer with a custom-designed extruder and controlling software. An important step in stabilizing the sugar after printing, templates are coated in a thin layer of a degradable polymer derived from corn. This coating allows the sugar template to be dissolved and to flow out of the gel through the channels they create without inhibiting the solidification of the gel or damaging the growing cells nearby. Once the sugar is removed, the researchers start flowing fluid through the vascular architecture and cells begin to receive nutrients and oxygen similar to the exchange that naturally happens in the body.

The whole process is quick and inexpensive, allowing the researchers to switch with ease between computer simulations and physical models of multiple vascular configurations.

"This new platform technology, from the cell's perspective, makes tissue formation a gentle and quick journey," Chen said, "because cells are only exposed to a few minutes of manual pipetting and a single step of being poured into the molds before getting nourished by our vascular network."

The researchers showed that human blood vessel cells injected throughout the vascular networks spontaneously generated new capillary sprouts to increase the network's reach, much in the way blood vessels in the body naturally grow. The team then created gels containing primary
'/>"/>

Contact: Evan Lerner
elerner@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. BUSM researchers identify role of FOXO1 gene in Parkinsons disease
2. How sweet it is: Tomato researchers discover link between ripening, color and taste
3. Researchers discover potential explanation for why a diet high in DHA improves memory
4. Rice researchers develop paintable battery
5. UMass Medical School researchers discover a new role for RNAi
6. Researchers develop new method for analyzing cell function
7. Maths formula leads researchers to source of pollution
8. 7 pharmaceutical companies join academic researchers to speed TB drug discovery
9. Researchers advance biometric security
10. Argonne researchers receive 4 R&D 100 awards
11. Researchers identify need to sample multiple tumor zones in breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn researchers improve living tissues with 3-D printed vascular networks made from sugar
(Date:4/20/2015)... Huntington Memorial Hospital is the first facility ... miniaturized, wireless monitoring sensor to manage heart failure (HF). ... FDA-approved heart failure monitoring device that has been proven ... to manage heart failure. The CardioMEMS HF ... pulmonary artery (PA) during a non-surgical procedure to directly ...
(Date:4/14/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... the growing mobile commerce market, announces that its Wocket® ... York Design Awards under the category  ,Product Design – ... Awards are part of a global multi-disciplinary awards program. ... the marketplace, industry and judging panel. Winners will be ...
(Date:4/9/2015)... , April 9, 2015 Synaptics Inc. (NASDAQ: ... solutions, announced today that it will report financial results ... April 23, 2015, after the close of market. The ... and investors at 2:00 p.m. PT (5:00 p.m. ET), ... To participate on the live call, analysts and ...
Breaking Biology News(10 mins):Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3Synaptics to Report Third Quarter Results on April 23 2
... study of apex predators in the Pacific Ocean found ... previously thought, unknown relationships between other species, and the ... of these sea creatures. The field program, dubbed ... at 23 species from 2000-09 and included researchers from ...
... WI, JUNE 22, 2011 -- Vinyl chloride is a ... anaerobic conditions. These solvents are used in many industrial ... most encountered groundwater pollutants in industrialized countries. Groundwater is ... to determine if vinyl chloride can be further degraded ...
... by psychologists at the University of Toronto and Tufts University ... sexual orientation when looking at his face, when she is ... thoughts or a mating goal heightens a woman,s ability to ... not apparent when a woman is judging another female,s orientation," ...
Cached Biology News:Decade-long study of Pacific predators shows importance of biological 'hotspots' 2Decade-long study of Pacific predators shows importance of biological 'hotspots' 3Psychologists find link between ovulation and women's ability to identify heterosexual men 2
(Date:4/28/2015)... April 28, 2015  US-Australian drug discovery company, Novogen ... it received a letter from NASDAQ informing it that ... 5550(b) (Listing Rule). In November 2014, ... the Company to submit a plan to regain compliance ... minimum of $2,500,000 in stockholders, equity as of June ...
(Date:4/28/2015)... 28, 2015 IMS is releasing ... it to the web and provide greater accessibility ... friendly reporting metrics increase data warehouse’s utility; plus, ... recall and access “on-the-go” makes data analysis even ... client feedback to assist in repository analytics and ...
(Date:4/28/2015)... 2015 Spartan Bioscience today announced that ... selected by the Ottawa Chamber of Commerce as one ... was selected from over 240 applicants based on his ... to Spartan, Dr. Lem founded Plexagen Diagnostics, and also ... holds a Medical Degree from the University of Ottawa, ...
(Date:4/27/2015)... - iCo Therapeutics ("iCo" or "the Company") (TSX-V: ICO) ... year ended December 31, 2014. Amounts, unless specified ... under International Financial Reporting Standards ("IFRS"). ... provide the outcome management and investors had hoped ... Therapeutics", said Andrew Rae , President & ...
Breaking Biology Technology:Novogen Regains Full Compliance with NASDAQ Listing Rule 2Novogen Regains Full Compliance with NASDAQ Listing Rule 3Spartan Bioscience Announces Paul Lem Named Ottawa’s Top 40 Under 40 2iCo Therapeutics Announces Year End 2014 Financial Results 2iCo Therapeutics Announces Year End 2014 Financial Results 3iCo Therapeutics Announces Year End 2014 Financial Results 4
... THOR ), a world leader in device-based mechanical,circulatory ... announced that it will report its operating results for ... on Thursday, October 30., The company will hold ... activities to all interested parties at 1:30 p.m.,Pacific Daylight ...
... QUEBEC CITY, Oct. 24 /PRNewswire-FirstCall/ - AEterna Zentaris ... biopharmaceutical company focused on,endocrine therapy and oncology, today ... Stock Market, notifying AEterna Zentaris that during the ... the bid price of the,Company,s common shares had ...
... Fastest-Growing Companies, TUSTIN, Calif., Oct. 24 ... a vertically integrated pharmaceutical company with major,operations in ... been recognized by,Deloitte LLP as the 6th fastest ... Technology Fast 50 Program., This nationally-recognized program ...
Cached Biology Technology:Thoratec Schedules Third Quarter 2008 Conference Call, Webcast 2AEterna Zentaris Receives Notification from Nasdaq Relating to Minimum Bid Price 2AEterna Zentaris Receives Notification from Nasdaq Relating to Minimum Bid Price 3AMDL, Inc. Named to Deloitte LLC Technology Fast 50 2AMDL, Inc. Named to Deloitte LLC Technology Fast 50 3AMDL, Inc. Named to Deloitte LLC Technology Fast 50 4