Navigation Links
Penn researchers identify molecular link between gut microbes and intestinal health
Date:11/3/2013

PHILADELPHIA - It's well established that humans maintain a symbiotic relationship with the trillions of beneficial microbes that colonize their bodies. These organisms, collectively called the microbiota, help digest food, maintain the immune system, fend off pathogens, and more. There exists a long and growing list of diseases associated with changes in the composition or diversity of these bacterial populations, including cancer, diabetes, obesity, asthma, and even autism.

Inflammatory bowel disease (IBD) is one of the best-studied diseases associated with alterations in the composition of beneficial bacterial populations. However, the nature of that relationship, and how it is maintained, has yet to be clarified.

Now, researchers at the Perelman School of Medicine at the University of Pennsylvania have identified a molecule that appears to play a starring role in this process.

David Artis PhD, associate professor of Microbiology, and colleagues report in Nature that the enzyme HDAC3 is a key mediator in maintaining proper intestinal integrity and function in the presence of friendly bacteria. What's more, HDAC3 and the genetic pathways it controls appears critical to maintaining a healthy balance between intestinal microbes and their host.

"HDAC3 in intestinal epithelial cells regulates the relationship between commensal bacteria and mammalian intestine physiology," says first author Theresa Alenghat VMD PhD, instructor in the Department of Microbiology.

That humans rely on their microbial cohabitants is hardly news. Much normal human physiology is attributable to our relationship to our microbiota.

The question that Alenghat and Artis and their colleagues wanted to answer is, "What are the molecular mechanisms that control this relationship, and how is it that this relationship goes wrong and can contribute to metabolic and inflammatory diseases?"

The team focused their effor
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Researchers Able to Identify that Benign Tumors from Use of Oral Contraceptive Have a Greater Chance of Becoming Malignant
2. Children of lower socioeconomic status grow up more susceptible to catching colds, Carnegie Mellon researchers find
3. University of Louisville researchers sign global licensing agreement
4. BUSM researchers study epigenetic mechanisms of tumor metastasis for improved cancer therapy
5. Researchers quantify toxic ocean conditions during major extinction 93.9 million years ago
6. Researchers discover how cancer invisibility cloak works
7. Oregon researchers say supplement cuts muscle loss in knee replacements
8. BUSM researchers identify molecule that could aid lung cancer detection, treatment
9. Researchers identify gene variant that raises risk for colorectal cancer from eating processed meat
10. Researchers show how plants tell the time
11. Berkeley Lab researchers get a detailed look at a DNA repair protein in action
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn researchers identify molecular link between gut microbes and intestinal health
(Date:1/22/2015)... , Jan. 15, 2015  BellBrook Labs, a leader ... announced the launch of a TR-FRET (time resolved ... Transcreener UDP Assay, a high throughput screening assay ... assay will allow for sensitive detection of hundreds ...
(Date:1/22/2015)... MUNICH , January 22, 2015 ... its tenth year  The European Patent Office to present ... Two British nominations to be featured: Christofer Toumazou ... week featuring former finalists and winners of the Award   ...
(Date:12/22/2014)... , Dec. 22, 2014  NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market, announces ... Apollo Robbins for the 2015 International CES debut of ... Robbins will be at the NXT-ID booth January 6th ...
Breaking Biology News(10 mins):BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4
... resulting from the nations nuclear weapons program lie in ... Beneath this desert landscape about two million curies ... chemicals are captured within the stratified vadose zone below ... These paths create uncertainties about where the contaminants go ...
... including those who helped decode the entire human genome ... 1mm long. The potato cyst nematode (PCN), Globodera ... particularly devastating in developing countries where the potato is a ... of Leeds to fully sequence its DNA, hopes to shed ...
... 26 Stinger Systems, Inc.,(OTC Bulletin Board: STIY), a ... Sheriff,s Department in Kansas has,purchased Stinger Systems, S-200 projectile ... the Stinger S-200 and,clearly felt that its features were ... the ruggedness of the product as well as its ...
Cached Biology News:Where does stored nuclear waste go? 2New research to decode the genetic secrets of prolific potato pest 2
(Date:1/22/2015)... , Jan. 22, 2015   GenoSpace , a precision medicine ... to enable the broad use of genomic, imaging and other ... appointment of Michelle Munson , CEO of Aspera, an ... Logo - http://photos.prnewswire.com/prnh/20150122/170713 "We ...
(Date:12/24/2014)... YORK , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, Inc. ... critical areas, announced the closing of an underwritten public offering ... up to an aggregate 3,500,000 shares of common stock, at ... warrant.  The warrants have a per share exercise price of ...
(Date:12/24/2014)... 2014 GMO corn cases filed across the ... the process of being consolidated in a Kansas federal court ... AG MIR 162 Corn Litigation, MDL No. 2591 in the ... of the Syngenta GMO corn multidistrict litigation (MDL) has been ...
(Date:12/24/2014)... Island, New York (PRWEB) December 23, 2014 ... and the Long Island Affiliate of ITRA Global, the national ... slow but steady recovery. This is evidenced by the ... the strong stock market. Low energy costs have held ...
Breaking Biology Technology:GenoSpace Expands Board with Appointment of Michelle Munson 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3
... Wis . - Non-controlling shareholders of Billerica, Mass.-based ... for the $135 million acquisition of their affiliate molecular ... firms are part of the Bruker family of companies, ... ,Bruker Optics produces a variety of spectrometers, including Fourier ...
... - The soaring prices of oil and natural gas ... matter instead of petroleum, and both biodiesel and gasoline containing ... , ,But the oil price hike has also fueled ... compounds that are the raw material for many modern plastics, ...
... Despite recent legislative setbacks, proponents of net neutrality said ... members of the United States Senate not to take ... provisions are included. , ,The pro-neutrality group It'sOurNet ... Senate to reject the telecommunications bill following a tie ...
Cached Biology Technology:UW prof turns sugar into diesel fuel, chemicals 2UW prof turns sugar into diesel fuel, chemicals 3Net neutrality will be back, supporters vow 2Net neutrality will be back, supporters vow 3Net neutrality will be back, supporters vow 4
Human VEGF R Phycoerythrin Sampler (Cl 89106, 49560, 54733)...
RABBIT ANTI NEOPTERIN...
MOUSE ANTI SIMIAN VIRUS 5:FITC Immunogen: Simian virus 5...
... • Dog serum is collected from fasted mixed ... age Available Anticoagulants: N-02: ... K2EDTA N-08: Potassium Oxalate ... N-05: ACD N-07: CPD ...
Biology Products: