Navigation Links
Penn researchers identify immune cells that fight parasites may promote allergies and asthma
Date:3/11/2010

PHILADELPHIA - Millions of people in both the developing and developed world may benefit from new immune-system research findings from the University of Pennsylvania School of Veterinary Medicine.

The Penn Vet researchers, studying how the immune system operates, have discovered a previously unidentified cell population that may be the body's double-edged sword, fighting off parasitic infections but also causing the harmful immune responses that can lead to allergies and asthma.

This cell population, termed multipotent progenitor cells, or MPP, appears to be activated in the context of allergies or infection with parasitic worms and may be one of the earliest cellular events in the developing immune response. The research published by David Artis, assistant professor in the Department of Pathobiology at Penn Vet, and colleagues may identify an important process in the immune response to helminth parasites and allergies.

A better understanding of what regulates the development of this cell population and what promotes its activation and function may aid in the development of drugs.

The research could benefit two patient populations: Those in developing countries still wrestling with parasitic worm infections and those in more industrialized environments where parasites are less prevalent but where immune responses can run amok, leading to a higher prevalence of allergies and asthma.

Millions worldwide struggle with health problems due to parasitic worms. These helminth worm parasites thrive in unsanitary conditions, in uncooked meat and in contaminated water. In more sanitary regions with fewer helminth parasites, the immune response that evolved to fight these infections may be redundant. It has been proposed that, due to reduced exposure to helminth parasites, the inactive immune response may inappropriately respond to substances like pollen, pollutants and some contents of food, resulting in exaggerated rates of asthma and allergy.

The National Institutes of Health estimates that as many as 40 to 50 million Americans suffer from allergic diseases. Consistent with this theory of redundancy, there are reports that show equatorial regions with an abundance of helminth parasites have populations that encounter lower rates of asthma and allergies.

"From an evolutionary perspective, it is likely that we evolved a complex immune response to fight parasitic worms, but our more sanitized environment no longer has this same population of parasites," Artis said. "This newly identified cell population could represent one of the earliest events in this type of immune response, which offers potential new targets for treatment of infection and allergic inflammation."

The research team demonstrated that a molecule called IL25, a member of the IL17 cytokine family, promotes the accumulation of a lineage-negative multipotent progenitor cell population in the intestine that promotes T cell responses associated with asthma and helminth infection. The resulting cell population gives rise to cells of macrophage and granulocyte lineages. The ability of IL25 to induce the emergence of an MPP cell population identifies a link between the IL17 cytokine family and extramedullary haematopoiesis and suggests a previously unrecognized innate immune pathway that promotes TH2 cytokine responses at mucosal sites.


'/>"/>

Contact: Jordan Reese
jreese@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

Related biology news :

1. VAI researchers develop tool to help study prostate cancer
2. Researchers examine plants ability to identify, block invading bacteria
3. Community involvement important in fight against childhood obesity, according to UTHealth researchers
4. Exercise counters negative effects of weight regain, researchers find
5. Rice researchers make graphene hybrid
6. New dinosaur rears its head; U-M researchers part of team announcing find
7. Discovery in legumes could reduce fertilizer use, aid environment: Stanford researchers
8. Researchers fishing for cancer cure discover active DHA derivatives
9. Researchers determine how ATP, molecule bearing the fuel of life, is broken down in cells
10. NOAA, NASA and Old Dominion researchers measure impacts of changing climate on ocean biology
11. Researchers issue outlook for a significant New England red tide in 2010
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/15/2017)... --  ivWatch LLC , a medical device company focused on improving ... of its ISO 13485 Certification, the global standard for medical device ... (ISO®). ... Monitoring device for the early detection of IV infiltrations. ... "This is an important milestone for ivWatch, as it ...
(Date:6/23/2017)... ITHACA, N.Y. , June 23, 2017 /PRNewswire/ ... leader in dairy research, today announced a new collaboration ... reduce the chances that the global milk supply is ... dairy project, Cornell University has become the newest academic ... Supply Chain, a food safety initiative that includes IBM ...
(Date:5/16/2017)... , May 16, 2017  Veratad Technologies, LLC ... of online age and identity verification solutions, announced today ... Identity Conference 2017, May 15 thru May 17, 2017, ... Building and International Trade Center. Identity ... globe and in today,s quickly evolving digital world, defining ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... Oct. 11, 2017  VMS BioMarketing, a leading provider of ... oncology Clinical Nurse Educator (CNE) network, which will launch this ... communication among health care professionals to enhance the patient care ... staff, and other health care professionals to help women who ... ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions are ... 5.5 million people each year. Especially those living in larger cities are affected by ... in one of the most pollution-affected countries globally - decided to take action. , ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator ... osteosarcoma. SBT-100 is able to cross the cell membrane and bind intracellular STAT3 ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... (ADC) therapeutics, today confirmed licensing rights that give it exclusive global access ... developed in collaboration with Children’s Hospital Los Angeles (CHLA). Additionally, an ...
Breaking Biology Technology: