Navigation Links
Penn researchers help solve questions about Ethiopians' high-altitude adaptations
Date:1/20/2012

PHILADELPHIA -- Over many generations, people living in the high-altitude regions of the Andes or on the Tibetan Plateau have adapted to life in low-oxygen conditions. Living with such a distinct and powerful selective pressure has made these populations a textbook example of evolution in action, but exactly how their genes convey a survival advantage remains an open question. Now, a University of Pennsylvania team has made new inroads to answering this question with the first genome-wide study of high-altitude adaptations within the third major population to possess them: the Amhara people of the Ethiopian Highlands.

Surprisingly, all three groups' adaptations appear to involve different genetic mutations, an example of convergent evolution.

"These three groups took different genetic approaches to solving the same problem," said senior author Sarah Tishkoff, a Penn Integrates Knowledge professor with appointments in the genetics department in Penn's Perelman School of Medicine and the biology department in the School of Arts and Sciences.

In addition to Tishkoff, the research was led by Laura B. Scheinfeldt, a research scientist in the genetics department at the Perelman medical school. Other members of the genetics department who contributed to the research are Sameer Soi, Simon Thompson, Alessia Ranciaro, William Beggs, Charla Lambert and Joseph P. Jarvis.

The Penn team collaborated with Dawit Wolde Meskel, Dawit Abate and Gurja Belay of the Department of Biology of Addis Ababa University.

Their research was published today in the journal Genome Biology.

One of the guiding principles behind evolution is natural selection; the more an organism is suited to its environment, the more likely it is to survive and pass on its genes. In high-altitude environments, oxygen concentration is low, a condition that can rapidly sicken even kill individuals who are not acclimated.

"As genetic
'/>"/>

Contact: Evan Lerner
elerner@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Notre Dame researchers report fundamental malaria discovery
2. Researchers find gene critical to sense of smell in fruit fly
3. Native forest birds in unprecedented trouble, according to University of Hawaii at Manoa researchers
4. Researchers discover green pesticide for citrus pests
5. 2-timing and hybrids: RUB researchers look back on 100 million years of evolution
6. Researchers identify possible receptor for key breast cancer regulator
7. UH Manoa researchers discover novel chemical route to form organic molecules
8. Researchers: Honeybee deaths linked to seed insecticide exposure
9. Worm seeks worm: Caltech researchers find chemical cues driving aggregation in nematodes
10. La Jolla Institute researchers identify pivotal immune cell in Type 1 diabetes in humans
11. Boston University School of Medicine researchers clarify link between salt and hypertension
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn researchers help solve questions about Ethiopians' high-altitude adaptations
(Date:1/22/2015)... , Jan. 20, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... commerce market, reports on the recent success of the Wocket™ smart wallet ... Wocket smart wallet was named as one of the "11 Hot ... "5 Best Products Launched At CES So Far" by Newseveryday.com and "The ...
(Date:1/22/2015)... 2015 , Europe,s ... The European Patent Office to present a video retrospective of the ... be featured: Christofer Toumazou and Sophie Wilson   ... winners of the Award   Starting on 22 January ...
(Date:1/22/2015)... Infinisource has launched its new NXG series of time clocks ... a higher standard for collecting attendance and labor data and ... installation, touch screen interface and seamless connection to cloud-based iSolved, ... solution for the small to mid-size employer. The ...
Breaking Biology News(10 mins):CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3Infinisource's NXG series sets new time clock standard 2
... is one of those diseases few have heard of unless ... usually a child or teenager -- it is devastating. Symptoms ... legs, vision impairment and slurred speech, but eventually the symptoms ... failure later in life. There is no cure at this ...
... road of a developing neuron, delivering to its tip a ... say. , In another piece of the puzzle of ... travels a portion of a neuron's backbone called the actin ... traffic area, says Dr. Wen-Cheng Xiong, developmental neurobiologist at the ...
... When a person's under stress or injured, the adrenal ... to normal. But the hormone's effects are many and ... create memories with short-term exposure, while impairing learning if ... of its effects,understanding how cortisol is made is essential ...
Cached Biology News:Moonlighting enzyme linked to neurodegenerative disease 2Moonlighting enzyme linked to neurodegenerative disease 3Motor protein plays key role in connecting neurons 2Scientists unravel clue in cortisol production 2
(Date:1/22/2015)... 2015  Derma Sciences, Inc. (Nasdaq: DSCI ... wound care, announces that AMNIOEXCEL® and AMNIOMATRIX®, amniotic ... to the Premier, Inc. Regenerative Skin Grafting contract ... AMNIOEXCEL® and AMNIOMATRIX® product lines, which continue to ...
(Date:12/24/2014)... 24, 2014  United Therapeutics Corporation (NASDAQ: UTHR ... MDT ) has submitted a pre-market approval application to ... use of Medtronic,s SynchroMed ® II implantable drug ... with United Therapeutics, Remodulin ® (treprostinil) Injection delivered ...
(Date:12/24/2014)...  Vermillion, Inc. (Nasdaq:   VRML), a bio-analytical solutions ... the Company closed its previously announced private placement ... W. Schuler , Birchview Fund LLC and several ... offering expenses.  The proceeds will be used for ...
(Date:12/24/2014)... 23, 2014 “Preparative & Process ... Flash), Consumables (Columns, Solvents, Buffers, Valves, Guages, Seals), ... Agriculture) - Forecasts to 2019” provides a detailed ... current market trends, and strategies impacting the preparative ...
Breaking Biology Technology:Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4
... 24 The Charlotte-Mecklenburg region,certainly has not been immune ... NC Free Clinic Association has seen their highest,demand for ... creator of,Charlotte,s premier health & wellness event, the Charlotte ... , "We can all have ...
... Extensive Experience In Molecular DiagnosticsSALT LAKE CITY, Feb. ... spine care through the development of molecular diagnostic ... has joined the executive management team as the ... Dr. Macina will report directly to Kenneth Ward, ...
... Ore. Researchers have identified the gene that ultimately ... that could some day lead to the repair of ... restoration or even the production of replacement teeth. , ... was already known to have several functions - in ...
Cached Biology Technology:Charlotte Anti-Aging Expo & Symposium Supports Free Clinics 2Axial Biotech Appoints Dr. Roberto Macina to Vice President of Research and Development 2Genetic discovery could lead to advances in dental treatment 2
Rabbit anti Xanthine Oxidase Xanthine Oxidase, Bovine Buttermilk...
... SilverSNAP Stain for Mass Spectrometry Applications ... spectrometry (MS) has emerged as a powerful ... of 2-D gels is now an important ... that leads ultimately to identification of specific ...
... Extraction Reagent is a liquid, ... means no scraping, no freeze-thaw ... M-PER Reagent, rapid lysis occurs ... room temperature, yielding 25% more ...
... Kits with ammonium sulfate are compatible with ... as Tfl, Tth, and Pfu DNA polymerases. ... PCR systems in one experiment by adding ... into the PreMixes supplied with the kit. ...
Biology Products: