Navigation Links
Penn researchers help nanoscale engineers choose self-assembling proteins
Date:5/31/2011

PHILADELPHIA Engineering structures on the smallest possible scales using molecules and individual atoms as building blocks is both physically and conceptually challenging. An interdisciplinary team of researchers at the University of Pennsylvania has now developed a method of computationally selecting the best of these blocks, drawing inspiration from the similar behavior of proteins in making biological structures.

The team was led by postdoctoral fellow Gevorg Grigoryan and professor William DeGrado of the Department of Biochemistry and Biophysics in Penn's Perelman School of Medicine, as well as graduate student Yong Ho Kim of the Department of Chemistry in Penn's School of Arts and Sciences. Their colleagues included members of the Department of Physics and Astronomy in SAS.

Their research was published in the journal Science today.

The team set out to design proteins that could wrap around single-walled carbon nanotubes. Consisting of a cylindrical pattern of carbon atoms tens of thousands of times thinner than a human hair, nanotubes are enticing to nanoengineers as they are extraordinarily strong and could be useful as platform for other nano-structures.

"We wanted to achieve a specific geometric pattern of the atoms that these proteins are composed of on the surface of the nanotube," Grigoryan said. "If you know the underlying atomic lattice, it means that you know how to further build around it, how to attach things to it. It's like scaffolding for future building."

The hurdle in making such scaffolds isn't a lack of information, but a surfeit of it: researchers have compiled databases that list hundreds of thousands of actual and potential protein structures in atomic detail. Picking the building materials for a particular structure from this vast array and assuring that they self-assemble into the desired shape was beyond the abilities of powerful computers, much less humans.

"Ther
'/>"/>

Contact: Evan Lerner
elerner@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers from the Viikki Biocenter discover how plants control the formation of wood cells
2. Researchers solve mammoth evolutionary puzzle: The woollies werent picky, happy to interbreed
3. What is a laboratory mouse? Jackson, UNC researchers reveal the details
4. MDC researchers discover key molecule for stem cell pluripotency
5. Researchers track the secret lives of feral and free-roaming house cats
6. UTHealth researchers find diabetics at higher risk of tuberculosis infection
7. UT Southwestern researchers find protein breakdown contributes to pelvic organ prolapse
8. UofL researchers replicate human kidney gene changes in mouse model
9. Researchers create nanopatch for the heart
10. NYU researchers outline method for DNA computation in new book
11. Seaports need a plan for weathering climate change, Stanford researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... study the unique bioelectric signaling system of the electric ... The OU researcher is working to understand how ... signals used to map the world around them. ... 500-600 discharges a second throughout their lives. The ... but necessary for survival. , "There is evidence that ...
(Date:9/19/2014)... , Sept. 19, 2014 Nxt-ID, Inc. (Nasdaq: ... company focused on the growing m-commerce market, updates the "Wocket in ... in the lightweight and light middleweight weight classes, Vinny Pazienza ... was announced that Game of Thrones actor Ciaran ... with Children star Katey Sagal have been cast ...
(Date:9/18/2014)... located deep in the primitive brainstem has revealed how ... Harvard School of Medicine and the University at Buffalo ... the second "sleep node" identified in the mammalian brain ... to produce deep sleep. , Published online in August ... fully half of all of the brain,s sleep-promoting activity ...
Breaking Biology News(10 mins):NXT-ID's Vinny Paz Celebrity Ad Wocket Update: Katey Sagal and Ciaran Hinds Attached to His Upcoming Movie 2NXT-ID's Vinny Paz Celebrity Ad Wocket Update: Katey Sagal and Ciaran Hinds Attached to His Upcoming Movie 3No sedative necessary: Scientists discover new 'sleep node' in the brain 2
... for detecting cocaine –?made with inexpensive, off-the-shelf electronics –?has ... University of California, Santa Barbara. Two local high school ... The potential applications of the sensor are far-reaching and ... high school students made their own sensors and collected ...
... that highly active antiretroviral therapy (HAART) is very cost-effective, ... shows that reimbursement to physicians treating patients with HIV ... study findings are reported in the April 1 issue ... HAART has led to dramatic decreases in illness and ...
... the ends of bones where they meet in a ... can lead to degenerative disease. Treatments and experimental approaches ... but currently there is no method to fully restore ... delivery of therapeutic proteins to the injured site is ...
Cached Biology News:Portable cocaine sensor developed at UC Santa Barbara 2Portable cocaine sensor developed at UC Santa Barbara 3Study shows AIDS drugs cost-effective, care underfunded 2Study shows AIDS drugs cost-effective, care underfunded 3Stem cells from muscles can repair cartilage 2Stem cells from muscles can repair cartilage 3
(Date:9/18/2014)... LONDON , Sept. 18, 2014 ... near-patient testing, is performed outside a clinical laboratory. ... hence in administrating appropriate treatments and medication. POCT ... and prevalence of lifestyle diseases such as diabetes, ... and user-friendly. POCT devices are standardized to minimize ...
(Date:9/18/2014)... 2014 Texas Governor Rick Perry, ... A&M Health Science Center CEO Brett Giroir, M.D., ... and Human Services (HHS), State of Texas and ... influenza vaccine manufacturing facility in Bryan, Texas, which ... the Texas A&M Biocorridor – a rapidly evolving ...
(Date:9/18/2014)... DUBLIN , Sept. 18, 2014 ... the "Global Companion Diagnostics (Polymerase Chain Reaction, In-situ ... report to their offering. The ... a CAGR of 22.7% from 2014 to 2019. Factors ... treatment, growing adoption of companion diagnostics by the pharmaceutical ...
(Date:9/18/2014)... SEATTLE , Sept. 18, 2014 /PRNewswire/ - Oncothyreon ... pricing of previously announced concurrent but separate underwritten offerings ... price to the public of $2.00 per share, for ... of its Series A Convertible Preferred Stock at a ... expected gross proceeds of $20 million. Each share of ...
Breaking Biology Technology:POCT Market in China 2014-2018 2Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 2Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 3Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 4Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to 2019 2Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to 2019 3Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 2Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 3
... was involved in the cloning of Dolly the sheep said ... coverage of embryonic stem cell research, which could be raising ... corner when they are at least a few years away. ... said news of the possibilities of human embryonic stem cell ...
... their best mind you, growing up was "Aftermath", an appropriate label ... 2006- Chicago. , ,As BIO 2006 - Chicago is still fresh ... the outcome, but so many others have already done so that ... more of the facts emerge (like the final attendance number). Suffice ...
... - A young company with a preventive solution to identity ... G. Steven Burrill Technology Business Plan Competition, but if area ... they better act quickly. , , Din and Newport ... plan. Khaja M. Din, president IPIC (Internet ...
Cached Biology Technology:Researchers say scientific reporting needs more perspective, less hype 2Researchers say scientific reporting needs more perspective, less hype 3BIO 2006 aftermath and a taste of bio-generics 2BIO 2006 aftermath and a taste of bio-generics 3BIO 2006 aftermath and a taste of bio-generics 4BIO 2006 aftermath and a taste of bio-generics 5BIO 2006 aftermath and a taste of bio-generics 6BIO 2006 aftermath and a taste of bio-generics 7BIO 2006 aftermath and a taste of bio-generics 8Winner of Burrill competition courted by North Carolina investors 2Winner of Burrill competition courted by North Carolina investors 3
Polyclonal Antibody to HADHB...
normal human fibroblasts Source: Cell Lysate Form: Ready to Use Application: Western Blotting Control...
A431 cells Source: Cell Lysate Form: Ready to Use Application: Western Blotting Control...
Purified anti-Fanconi anemia D2-Phosphorylated (Ser222)...
Biology Products: