Navigation Links
Penn researchers help graft olfactory receptors onto nanotubes
Date:7/26/2011

ly what molecules are bound to them," Johnson said.

As the particular GPCR the team worked with was an olfactory receptor, the test case for their nanotube device was to function as sensor for airborne chemicals.

"If there's something in the atmosphere that wants to bind to this molecule, the signal we get through the nanotube is about what fraction of the time is something bound or not. That means we can get a contiguous read out that's indicative of the concentration of the molecule in the air," Johnson said.

While one could imagine scaling up these nanotube devices into a synthetic nose making one for each of the approximately 350 olfactory GPCRs in a human nose, or the 1,000 found in a dog's Johnson thinks that medical applications are much closer to being realized.

"GPCRs are common drug targets," he said. "Since they are known to be very important in cell-environment interactions, they're very important in respect to disease pathology. In that respect, we now have a pathway into interrogating what those GPCRs actually respond to. You can imagine building a chip with many of these devices, each with different GPCRs, and exposing them all at once to various drugs to see which is effective at triggering a response."

Figuring out what kinds of drugs bind most effectively to GPCRs is important because pathogens often attack through those receptors as well. The better a harmless chemical attaches to a relevant GPCR, the better it is at blocking the disease.

The Penn team also made a technical advancement in stabilizing GPCRs for future research.

"In the past, if you take a protein out of a cell and put it onto a device, it might last for a day. But here, we embedded it in a nanoscale artificial cell membrane, which is called a nanodisc," Johnson said. "When we did that, they lasted for two and half months, instead of a day."

Increasing the lifespans of such devices could be beneficial to t
'/>"/>

Contact: Evan Lerner
elerner@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. U of M researchers may have discovered key to help women fight infections during pregnancy
2. Behavior 2011 to draw global contingent of more than 1,100 animal researchers to IU next week
3. U of M researchers discover gene required to maintain male sex throughout life
4. Caltech researchers create the first artificial neural network out of DNA
5. Western researchers receive $600,000 to study Prion diseases and Alzheimers
6. Researchers find potential key for unlocking biomass energy
7. Researchers present new trends in HIV cure research, call for proactive outreach programs to prevent HIV transmission in injecting drug users, and demand increased commitments to improving maternal and child health
8. E-health records should play bigger role in patient safety initiatives, researchers advocate
9. John Theurer Cancer Center researchers shared 14 leading edge studies at recent ASCO meeting
10. Researchers provide means of monitoring cellular interactions
11. USC researchers explore the source of empathy in the brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... has awarded the Oklahoma Medical Research Foundation a five-year, ... and the bacteria,s effects on humans. , For ... colleagues have studied the human immune response to anthrax ... Immunology. The original funding came soon after anthrax-laced letters ... the terrorist attacks of Sept. 11, 2001. , ...
(Date:8/20/2014)... have suffered concussions ready to return to action? A ... school athletes who head back on the field with ... in their abilities to simultaneously walk and do simple ... in their balance and/or altered walking speed, was found ... had returned to activity in less than a month. ...
(Date:8/20/2014)... pepper causes a burning spiciness that is irresistible to ... pepper,s effect are using their findings to develop a ... can be caused by inflammation or other problems. They ... tested in clinical trials, in ACS, Journal of ... that decades ago, scientists had pegged a compound called ...
Breaking Biology News(10 mins):$14.5 million grant awarded to continue anthrax studies 2Recovery reversal seen in Oregon study of returning concussed athletes 2Recovery reversal seen in Oregon study of returning concussed athletes 3
... neck cancer is the sixth most common type of cancer ... young women without any known risk factors. Now, researchers at ... movement of precancerous cells in the mouth and thus promote ... The new results, published in the January issue of ...
... SPRING HARBOR, N.Y. (Mon., Jan. 3, 2011) -- ... the study of organogenesis. Organogenesis, essentially the process ... organ, has important connections to biological processes at the ... potential for medical treatments through tissue engineering approaches. ...
... (PHILADELPHIA) An international team of researchers led ... Penn Medicine,s Institute for Translational Medicine and Therapeutics, ... Paris-based Fondation Leducq to study the molecular genetics ... Mechanisms of Novel Genes Associated with Plasma Lipids ...
Cached Biology News:Estrogen may help precancerous cells spread in oral cavity 2Transcriptome analysis, organ culture methods featured in Cold Spring Harbor Protocols 2Penn Medicine researcher receives $6 million grant for cardiovascular disease study 2
(Date:8/19/2014)... 2014 A Geisinger researcher on a personal ... Centers for Disease Control and Prevention (CDC) award recognizing ... concern. Joseph Boscarino , Ph.D. MPH, ... team of researchers nominated for the Centers for Disease ... for Data Methods and Study Design. "Hepatitis ...
(Date:8/19/2014)... Research and Markets ... "Spectroscopy Equipment and Accessories - Global Strategic ... This report analyzes the ... in US$ Thousands by the following Product ... NMR-EPR Spectrometers, Near Infrared (NIR) Spectrometers, IR ...
(Date:8/19/2014)... Sales Horizons, a leader in sales training, today ... training course to help companies develop clinical staff ... the majority of their time on client sites – ... practice – providing support and education to both clinical ... believes clinical staff are and should be considered an ...
(Date:8/18/2014)... 18, 2014   Sterne, Kessler, Goldstein & Fox ... Washington, DC , announced today that it ... (IPR) with the U.S. Patent and Trademark Office ... BioReference Laboratories, Inc. (Nasdaq: BRLI).  These IPR petitions aim ... Myriad Genetics, Inc. These patents have been asserted against ...
Breaking Biology Technology:Geisinger investigator nominated for federal award 2Geisinger investigator nominated for federal award 3Global Spectroscopy Equipment and Accessories - Strategic Business Report 2014 2Sales Horizons Launches a New Online Sales Training Course for MedTech Clinical Staff to Develop Their Sales Skills 2Sales Horizons Launches a New Online Sales Training Course for MedTech Clinical Staff to Develop Their Sales Skills 3Sterne Kessler Files 11 IPR Petitions On Behalf Of GeneDx, Inc., Subsidiary Of BioReference Laboratories, Inc. 2Sterne Kessler Files 11 IPR Petitions On Behalf Of GeneDx, Inc., Subsidiary Of BioReference Laboratories, Inc. 3
... Jan. 11, 2011 Fred Hutchinson Cancer Research Center ... Robert Eisenman, Ph.D., a molecular biologist and geneticist, have ... Advancement of Science, or AAAS. Election as a fellow ... peers. Brent, a member of the Hutchinson ...
...  Reportlinker.com announces that a new market research report is ... China News 1011 http://www.reportlinker.com/p0358381/Industrial-Biotechnology-China-News-1011.html ... it,s even not past." Owing to the monetary easing ... started to affect almost all industries in China, including ...
... January 2011 Elsevier announced today that ... Carbon Nanotubes and Nitrides, will occur on 4-8 September ... discusses the significant improvements in material growth processes, material ... few years. The improvements have lead to the discovery ...
Cached Biology Technology:Roger Brent and Robert Eisenman Named AAAS Fellows 2Roger Brent and Robert Eisenman Named AAAS Fellows 3Reportlinker Adds Industrial Biotechnology China News 1011 2
WASF2 Immunogen: WASF2 (NP_008921, 73 a.a. ~ 173 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Anti 7H6 Antigen (tight-junction associated protein Antigen) Monoclonal Antibody 7H6...
...
Sheep polyclonal to Malate Dehydrogenase ( Abpromise for all tested applications). Antigen: Full length protein - Pig heart malate dehydrogenase. Entrez Gene ID: 4190 Swiss Protein ID: P...
Biology Products: