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Penn researchers help graft olfactory receptors onto nanotubes
Date:7/26/2011

PHILADELPHIA Penn researchers have helped develop a nanotech device that combines carbon nanotubes with olfactory receptor proteins, the cell components in the nose that detect odors.

Because olfactory receptors belong to a larger class of proteins that are involved in passing signals through the cell membrane, these devices could have applications beyond odor sensing, such as pharmaceutical research.

The research was led by professor A. T. Charlie Johnson, postdoctoral fellow Brett R. Goldsmith and graduate student Mitchell T. Lerner of the Department of Physics and Astronomy in the School of Arts and Sciences, along with assistant professor Bohdana M. Discher and postdoctoral fellow Joseph J. Mitala Jr. of the Department of Biophysics and Biochemistry at Penn's Perelman School of Medicine. They collaborated with researchers from the Monell Chemical Senses Center, the University of Miami, the University of Illinois, Princeton University and two private companies, Nanosense Inc. and Evolved Machines Inc.

Their work was published in the journal ACS Nano.

The Penn team worked with olfactory receptors derived from mice, but all olfactory receptors are part of a class of proteins known as G Protein Coupled Receptors, or GPCRs. These receptors sit on the outer membrane of cells, where certain chemicals in the environment can bind to them. The binding action is the first step in a chemical cascade that leads to a cellular response; in the case of an olfactory receptor, this cascade leads to the perception of a smell.

The Penn team succeeded in building an interface between this complicated protein and a carbon nanotube transistor, allowing them to convert the chemical signals the receptor normally produces to electrical signals, which could be incorporated in any number of tools and gadgets.

"Our nanotech devices are read-out elements; they eavesdrop on what the olfactory receptors are doing, specifical
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Contact: Evan Lerner
elerner@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

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