Navigation Links
Penn researchers discover genetic risk factor for testicular cancer
Date:5/31/2009

(PHILADELPHIA) Researchers at the University of Pennsylvania School of Medicine have uncovered variation around two genes that are associated with an increased risk of testicular cancer. Testicular cancer is the most common cancer among young men, and its incidence among non-Hispanic Caucasian men has doubled in the last 40 years -- it now affects seven out of 100,000 white men in the United States each year. The discovery, published in the May 31, 2009 online issue of Nature Genetics, is the first step toward understanding which men are at high risk of disease.

"Despite being quite heritable, there really have not been any clear genetic risk factor that can account for most cases of testicular cancer," says Katherine L. Nathanson, MD, an assistant professor of Medicine and a specialist in medical genetics at the Abramson Cancer Center. "These variants are the first striking genetic risk factors found for this disease to date."

Nathanson and co-author Peter A. Kanetsky, PhD, MPH, an assistant professor of Epidemiology, found that men who have two copies of the common version of the c-KIT ligand (KITLG) gene have a 4.5-fold higher risk of testicular cancer than men who have two copies of the less common or minor version of the gene. Additionally, men with two copies of the common version of variants next to another gene, sprouty 4 (SPRY4), have a 1.48-fold higher risk than men with two copies of the less common version of the gene.

While researchers suspect environmental exposures may play a part in the growing incidence, they now know that an individual's genes also play a major role in disease susceptibility.

"This finding is quite different than those observed in many other genome-wide association studies," Nathanson says. "In most studies, the increased risk of disease is associated with the less common variant of the gene. In this case, it is the more common variant in Caucasians that is associated with risk. If y
'/>"/>

Contact: Holly Auer
holly.auer@uphs.upenn.edu
215-200-2313
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... , June 30, 2015 Genisphere ... as CEO to help further develop Genisphere,s therapeutics capabilities ... partnering experience, having spent much of the last 25 ... Amgen, Baxter Bioscience, and Johnson & Johnson. Tom started ... Technology and Biotech Corporate Finance. He graduated from Dartmouth ...
(Date:6/26/2015)... June 26, 2015 ATL Technology, LLC, a top ... specialties in single use solutions, headquartered in Springville, ... (a California corporation with locations in ... San Jose, Costa Rica ). This acquisition ... with ATL Technology,s existing facility in ...
(Date:6/25/2015)... , June 25, 2015  Imagine a tool specifically ... a healthier, happier life. That,s exactly what USANA,s ... do. The cutting-edge, portable health program provides a personalized ... to help improve your lifestyle and nutrition. ... and gala Wednesday night, USANA,s THA was honored with ...
Breaking Biology News(10 mins):Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3ATL Technology Announces Acquisition of MedConx, Inc. and Expanded Global Footprint 2@USANAinc's Personalized Nutrition Program Wins Industry Innovation Award 2
... Two years of painstaking observation on the social interactions ... of their family trees has found signs of natural ... Rhesus macaques who had large, strong networks tended to ... Duke University team of researchers. And their ability to ...
... Marine biologists are beginning to understand the varied diving ... from multisensor tags attached to the animals with suction ... as echolocation, are providing a wealth of fine detail ... their prey. , Recent studies on the behavior ...
... 2013) -- A new study by NYU School of Medicine researchers ... Helicobacter pylori ( H. pylori ) isn,t implicated in the ... protect against stroke and some cancers. The findings, based a nationwide ... 12 years, are published online, January 9, in the journal ...
Cached Biology News:Networking ability a family trait in monkeys 2Networking ability a family trait in monkeys 3Whales' foraging strategies revealed by new technology 2Disappearing bacterium may protect against stroke 2Disappearing bacterium may protect against stroke 3
(Date:7/7/2015)... , ... July 07, 2015 , ... ... together to lower barriers to innovation in life science R&D, has attracted a ... last quarter include another top ten pharmaceutical company joining as a Core member, ...
(Date:7/6/2015)...  Approximately 1% of the population inherits a common ... individuals are three times more likely to develop angina, ... the nation,s leading medical journals by researchers from the ... Photo - http://photos.prnewswire.com/prnh/20150706/230685 The ... (also known as "sixth disease") and occasional seizures in ...
(Date:7/6/2015)... Calif. , July 6, 2015  Viveve Medical, Inc. ... that Patricia Scheller , Viveve,s Chief Executive Officer, and ... live at VirtualInvestorConferences.com on July 9, 2015. , ... 2015 , , , , TIME:     , ... LINK: , , , http://tinyurl.com/viveve   , ...
(Date:7/3/2015)... ... July 03, 2015 , ... ... for use in applications such as animal waste reduction, bioremediation, wastewater treatment, ... restaurant kitchen settings, announced today that it will be showcasing, ManureMagicâ„¢, its ...
Breaking Biology Technology:Pistoia Alliance Continues to Attract New Members 2Inherited Herpes Virus Increases the Risk of Angina Reports HHV-6 Foundation 2Inherited Herpes Virus Increases the Risk of Angina Reports HHV-6 Foundation 3Viveve to Webcast Live at VirtualInvestorConferences.com 2Viveve to Webcast Live at VirtualInvestorConferences.com 3DryLet to Highlight Benefits of Patented ManureMagicâ„¢ at North American Manure Expo in Chambersburg, PA July 14-15, 2015 2
... Entrepreneurs who came to the Wisconsin Entrepreneurs Conference, held ... of reasons: to gain information on starting a company, ... with fellow entrepreneurs in the state. , ,However, at ... to the assembled entrepreneurs and industry representatives by the ...
... project failure rates. Youve probably heard mention of all the ... and scope definition, lack of business relevance or bad communication. ... hand wringing is the real root cause. Its the people. ... one, the source is the failure of specific individuals or ...
... economy has been a little slow in coming, perhaps ... store in a non-volatile way. Virent , a ... problems at once. , ,Jim Dumesic, a University of ... explained how at the Nanotechnology Conference last ...
Cached Biology Technology:Celebrating Wisconsins entrepreneurial spirit 2Celebrating Wisconsins entrepreneurial spirit 3Analog people in the digital revolution 2Analog people in the digital revolution 3Virent shows off its hydrogen-fuel plans 2
...
... from different Cynomolgus monkey normal tissues ... available upon request. Customers can ... whole set, and pay 70% of ... Dr. P Set products are for ...
... consists of AmnioMAX-C100 Basal ... and AmnioMAX-C100 Supplement (Cat. ... complete with antibiotics and ... requires no further supplementation ...
Anti-Dynamin Monoclonal Antibody Description: 100 g Research Focus: neuroscience Storage: -20C Shipping Temperature: 4C...
Biology Products: