Navigation Links
Penn research team tests bedside monitoring of brain blood flow and metabolism in stroke victims
Date:3/2/2009

PHILADELPHIA A University of Pennsylvania team has completed the first successful demonstration of a noninvasive optical device to monitor cerebral blood flow in patients with acute stroke, a leading cause of disability and death.

The ultimate goal of this research is to improve the management of patients with stroke and other brain disorders by providing continuous bedside monitoring of brain blood flow and metabolism.

"Our preliminary study demonstrates that blood flow changes can be reliably detected from stroke patients and also suggests that blood flow responses vary significantly from patient to patient," lead author Turgut Durduran said.

Ischemic stroke is the leading cause of morbidity and long-term disability in the United States, with projected cost of stroke care estimated at trillions of dollars during the next five decades. Stroke accounts for nearly 10 percent of deaths in the western hemisphere and about 5 percent of health-care costs.

The device being developed uses embedded optical probes that are placed over major cortical blood vessels in each hemisphere of the brain. The technology, diffuse correlation spectroscopy is a non-invasive system that uses lasers, photon-counting detectors, radio-frequency electronics, data processors and a computer monitor to display user-friendly images of functional information to physicians and nurses.

"What we have demonstrated is a working prototype of a non-invasive brain probe that uses diffusing light to detect physiological changes such as blood flow, blood-oxygen saturation and hemoglobin concentration to inform clinicians about their treatments," Arjun Yodh, professor of physics in the School of Arts and Sciences at Penn and principal investigator of the study, said.

The study is part of a $2.8 million, five-year Bioengineering Research Partnership grant from the National Institutes of Health and the University of Pennsylvania Comprehensive Neuroscience Center. BRP grants are awarded to interdisciplinary teams that combine basic, applied and translational research for important biological or medical problems. Yodh is joined by Rick Van Berg from the High Energy group of the Department of Physics in the School of Arts and Sciences and clinical collaborators John Detre, Joel Greenberg and Scott Kasner from the Department of Neurology in the School of Medicine at Penn.

"Stroke is caused by a reduction in blood flow to the brain, yet brain blood flow is rarely if ever measured in stroke patients because most existing methods to measure blood flow require costly instrumentation that is not portable," Detre said. "The ability to quantify tissue hemodynamics at the bedside would provide new opportunities both to learn more about blood-flow changes in patients with acute stroke and to optimize interventions to increase blood flow for individual patients, potentially even allowing these interventions to be administered before the onset of new neurological symptoms."


'/>"/>

Contact: Jordan Reese
jreese@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

Related biology news :

1. Research shows skeleton to be endocrine organ
2. Newly created cancer stem cells could aid breast cancer research
3. Dominant cholesterol-metabolism ideas challenged by new research
4. Researchers identify proteins involved in new neurodegenerative syndrome
5. Texas researchers and educators head for Antarctica
6. MGH researchers describe new way to identify, evolve novel enzymes
7. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
8. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
9. U of MN researchers discover noninvasive diagnostic tool for brain diseases
10. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
11. Story ideas from the Journal of Lipid Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/3/2017)...  Data captured by IsoCode, IsoPlexis Corporation,s ... statistically significant association between the potency of ... objective response of cancer patients post-treatment. The ... cancer patients will respond to CAR-T cell ... to improve both pre-infusion potency testing and cell ...
(Date:3/30/2017)... , March 30, 2017 Trends, opportunities and ... and behavioral), by technology (fingerprint, AFIS, iris recognition, facial ... and others), by end use industry (government and law ... financial and banking, and others), and by region ( ... , Asia Pacific , and the ...
(Date:3/27/2017)... 2017  Catholic Health Services (CHS) has been ... (HIMSS) Analytics for achieving Stage 6 on the ... In addition, CHS previously earned a place in ... electronic medical record (EMR). "HIMSS Analytics ... EMR usage in an outpatient setting.  This recognition ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... 2017 International research firm Parks Associates announced today ... the TMA 2017 Annual Meeting , October 11 in ... home security market and how smart safety and security products impact the ... Parks Associates: Smart Home Devices: ... "The residential security market has experienced ...
(Date:10/9/2017)... Oct. 9, 2017  BioTech Holdings announced today ... which its ProCell stem cell therapy prevents limb ... The Company, demonstrated that treatment with ProCell resulted ... saved as compared to standard bone marrow stem ... resulted in reduction of therapeutic effect.  ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... 2017, in the medical journal, Epilepsia, Brain Sentinel’s SPEAC® System which uses ... EEG, in detecting generalized tonic-clonic seizures (GTCS) using surface electromyography (sEMG). The ...
(Date:10/6/2017)... Boston, Mass. (PRWEB) , ... October 06, 2017 ... ... spotlight female entrepreneurship within the healthcare and technology sector at their fourth annual ... six panels featuring 30 inspiring speakers and the ELEVATE pitch competition showcasing early ...
Breaking Biology Technology: