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Penn research points to new way of preserving fertility for boys undergoing cancer treatment
Date:3/28/2012

ing. After demonstrating that the cryopreserved cells implanted in the right region of the testes and underwent normal spermatogenesis, the researchers extracted the sperm and successfully fertilized eggs in vitro.

One of the recipient mice was also placed with females and successfully sired offspring. The offspring resulting from eggs fertilized in vitro as well as those resulting from natural mating all produced normal appearing young. Most importantly, the offspring arising from the cryopreserved spermatogonial stem cells appeared free of genetic damage.

This experiment clearly points in the right direction for the feasibility of a similar fertility treatment in humans.

"Human and animal spermatagonial stem cells have been successfully frozen for short periods of time, but this is completely different," Brinster said. "Here we had cells frozen for over a decade that implanted in the right place and made sperm, and that sperm made offspring without apparent genetic defects."


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Contact: Evan Lerner
elerner@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

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