Navigation Links
Penn research identifies potential mechanisms for future anti-obesity drugs
Date:3/3/2011

in governing energy balance regulation," Grill said.

The Penn group not only identified a necessary part of the brain which mediates the food intake suppression effect produced by these drugs, the nucleus tractus solitarius, or NTS, but also the cellular signaling pathways required for production of GLP-1's satiety effects.

"GLP-1's ability to alter these specific signaling pathways within the NTS of the brainstem may account for the suppression in food intake and body weight by altering the long-term neurochemistry and connectivity of this region of the brain with higher-order brain centers that also regulate energy balance," Bence said.

Many researchers have tried to determine precisely how GLP-1 and other satiating signals work, especially since in obese individuals, the brain fails to correctly perceive and respond to naturally occurring energy balance signals from the body. This faulty signaling underscores the importance of pharmacological treatments, such as the long-acting GLP-1 drugs that are effective in engaging brain signaling to reduce excessive food intake and possibly obesity.

That the Penn researchers were able to demonstrate a potential neurochemical mechanism of weight loss for a class of drugs already used in the treatment of type 2 diabetes provides a missing piece of the puzzle for future FDA-approved anti-obesity drugs.

"If we can identify other chemical signals or hormones that act on the same pathways that we've shown here, then by combined action you have a coordinated, orchestrated symphony of weight suppression," Hayes said.


'/>"/>

Contact: Evan Lerner
elerner@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scripps oceanography researchers discover arctic blooms occurring earlier
2. Nature study: Jefferson researchers unravel proteins elusive role in embryo and disease development
3. York U researchers uncovering how ovarian cancer resists chemotherapy
4. Research shows how bacteria communicate with each other
5. Researchers predict age of T cells to improve cancer treatment
6. Stem cell study could aid motor neurone disease research
7. Researchers looking at a rare disease make breakthrough that could benefit everyone
8. Silk moths antenna inspires new nanotech tool with applications in Alzheimers research
9. Researchers develop curious snapshot of powerful retinal pigment and its partners
10. Winners to share $1 million prize in Office of Naval Research challenge
11. 20 researchers selected as 2011 Leopold Leadership Fellows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... better decisions about what they eat, the Food and ... to the Nutrition Facts label found on nearly every ... Chemical & Engineering News (C&EN), the weekly news ... updates and the fight that has ensued. , ... that while the Nutrition Facts label has remained largely ...
(Date:7/30/2014)... of Engineering recently received a $330,000 award from ... synthesis of organic nanorods." , According to ... and utilization of functional materials, devices, and systems ... in scaling up nanotechnology is the lack of ... one device. A research team led by Dr. ...
(Date:7/30/2014)... treatment has been shown to relieve patients, pain. ... transmission between the peripheral and central nervous systems, ... Radiation Medicine, Chinese Academy of Medical Sciences, China ... dorsal root ganglia (DRG) to provide relief for ... 14.8, 29.6 MBq) were implanted separately into the ...
Breaking Biology News(10 mins):NSF grant to Wayne State supports new concept for manufacturing nanoscale devices 2
... chemicals routinely added to consumer products from carpets to ... Health officials, however, are concerned that one class of ... more than reducing fire-related injuries and property damage. ... distributed in the environment as contaminants, and trace levels ...
... testing for adult-onset diseases, including cancer, is generally discouraged ... be helpful. Yet, many children of BRCA mutation ... years before preventive interventions are indicated. ... Clinical Oncology, describes the prevalence and experiences of parental ...
... PICK: Can cancer drugs combine forces? ... with a drug known as imatinib (Gleevec), which targets ... their disease returns, because BCR-ABL mutants emerge that are ... with a drug known as dasatinib (SPRYCEL), which targets ...
Cached Biology News:SRMs track fire retardants in humans and environment 2JCI table of contents: Aug. 16, 2007 2JCI table of contents: Aug. 16, 2007 3JCI table of contents: Aug. 16, 2007 4JCI table of contents: Aug. 16, 2007 5JCI table of contents: Aug. 16, 2007 6JCI table of contents: Aug. 16, 2007 7
(Date:7/30/2014)... , July 30, 2014   Epic Sciences, Inc. ... develops novel diagnostics to personalize and advance the treatment ... Gregory T. Lucier as chairman of Epic,s ... CEO of Life Technologies (formerly Invitrogen). Mr. Lucier joins ... commercializes its circulating rare cell analysis platform with special ...
(Date:7/30/2014)... 2014 Connecticut Center for Advanced Technology, ... East Hartford, Conn., was awarded a Rural Business Enterprise ... project that will determine the feasibility of implementing an ... USDA Rural Development provided $53,000 for CCAT under the ... phase of the feasibility study in fiscal year 2014. ...
(Date:7/30/2014)... LayerBio, Inc., an MIT spinoff developing novel drug ... seed financing from friends and family investors. Proceeds from ... novel sustained-release product for ophthalmology. , "We are grateful ... to this important work," said Dr. Ken Mandell, Founder ... areas in which innovations in drug delivery have already ...
(Date:7/29/2014)... The advanced optical methods and applications for ... a revolution in the neurosciences were the inspiration behind ... SPIE, the international society for optics and photonics ... of the BRAIN Initiative in the United States, and ... vision for and provide examples of the impact that ...
Breaking Biology Technology:Epic Sciences Appoints Greg Lucier as Chairman of the Board of Directors 2Epic Sciences Appoints Greg Lucier as Chairman of the Board of Directors 3USDA Grant Funds Second Phase of Bio-Energy Research Community Economic Development in CT 2USDA Grant Funds Second Phase of Bio-Energy Research Community Economic Development in CT 3SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 2SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 3SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 4
... historians, journalists and politicians, and has been recounted everywhere from ... forces used chemical weapons on Iraqis just after World War ... squared with the historical record, says R. M. Douglas, a ... the December issue of The Journal of Modern History ...
... at the University of East Anglia (UEA) could contribute ... agricultural waste to generate clean electricity. Published today ... National Academy of Sciences (PNAS), the researchers have ... some bacteria survive by ,breathing rocks,. The findings ...
... roadside bombs to freeway crashes. Traumatic injury, the leading cause ... the body,s natural blood-clotting process. In an effort to ... a new Case Western Reserve University biomedical engineering professor, and ... that show promise in halting internal and external bleeding. Their ...
Cached Biology Technology:Despite claims, UK did not gas Iraqis in the 1920s, new research finds 2Despite claims, UK did not gas Iraqis in the 1920s, new research finds 3Despite claims, UK did not gas Iraqis in the 1920s, new research finds 4'Rock-breathing' bacteria could generate electricity and clean up oil spills 2Researchers take the inside route to halt bleeding 2
... Time-resolved microscopy is the ultimate tool ... subcellular structures. Its applications previously have been ... because microscope optics do not transmit in ... leader in fluorescence spectroscopy, introduces a filter-based ...
... clear dishes with stacking feature for easy storage. ... number, created to easily match Cornings product number. ... the old Sigma-Aldrich number (Z70,947-6) or contact customer ... surface Comp Dim: surface area 55 cm 2 ...
... Mixes are formulated for use in one-step ... Green. One-step QRT-PCR mixes offer a quick ... pipetting steps are minimised, making the protocol ... 2x ABsolute QRT-PCR Mix is supplied with ...
... and pathophysiological stressful conditions trigger the synthesis ... heat shock proteins (HSPs), more appropriately called ... Hsp90 family of proteins in mammalian cells ... and Trap-1 (Hsp75). It was found that ...
Biology Products: