Navigation Links
Penn research identifies potential mechanisms for future anti-obesity drugs
Date:3/3/2011

PHILADELPHIA An interdisciplinary group of researchers at the University of Pennsylvania has, for the first time, identified the neurological and cellular signaling mechanisms that contribute to satiety the sensation of feeling full and the subsequent body-weight loss produced by drugs used to treat type 2 diabetes. More comprehensive knowledge of these mechanisms could form the basis for anti-obesity medications.

The group was led by Matthew Hayes of the School of Medicine's Psychiatry Department, Harvey Grill of the Psychology Department in the School of Arts and Sciences and Kendra Bence of the School of Veterinary Medicine's Animal Biology Department. Their research was aided by a team of postdoctoral and doctoral fellows, as well as technicians and undergraduate students at Penn.

The study was published in the March 2 edition of the journal Cell Metabolism.

While no pharmaceutical treatment for obesity currently exists, type 2 diabetes drugs targeting the hormone glucagon-like-peptide-1, or GLP-1, for insulin production may hold promise. These drugs were known to promote weight loss, simply as a result of patients eating less. Researchers, however, could not explain exactly what caused this change in behavior.

Naturally occurring GLP-1 is made in primarily two distinct locations in the body, the gut and the brain. Much of the previous research in this area has focused on the former at the expense of the latter when attempting to identify the relevant population of GLP-1 receptors that may mediate the suppression in food intake by pharmaceutical GLP-1 drugs.

"Identifying both the site-of-action and mechanisms that accounts for the body weight loss of these GLP-1 drugs puts us one step closer to developing effective, FDA-approved, treatments for obesity," Hayes said.

"Ignoring the brain is not the right strategy, as these drugs are certainly engaging multiple, distributed centers in the bra
'/>"/>

Contact: Evan Lerner
elerner@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scripps oceanography researchers discover arctic blooms occurring earlier
2. Nature study: Jefferson researchers unravel proteins elusive role in embryo and disease development
3. York U researchers uncovering how ovarian cancer resists chemotherapy
4. Research shows how bacteria communicate with each other
5. Researchers predict age of T cells to improve cancer treatment
6. Stem cell study could aid motor neurone disease research
7. Researchers looking at a rare disease make breakthrough that could benefit everyone
8. Silk moths antenna inspires new nanotech tool with applications in Alzheimers research
9. Researchers develop curious snapshot of powerful retinal pigment and its partners
10. Winners to share $1 million prize in Office of Naval Research challenge
11. 20 researchers selected as 2011 Leopold Leadership Fellows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... When researchers at the National Institute of Standards ... do their work more effectively, they often prove ... Such was the case recently for M. Lorna ... in the growing specialization of glycomics. Glycomics is ... called glycans that are attached to proteins and ...
(Date:7/11/2014)... University, Sweden, have explored two different ways that ... leading to the formation of oxygen molecules in ... the scientific journal Nature Communications . , ... synthetic catalysts for water oxidation, which are key ... direct storage of solar energy in fuels like ...
(Date:7/11/2014)... evidence that under the normal circumstances, astrocytes ... maintain neuronal environment, and exhibit therapeutic and ... disease. Previous studies have found that nerve ... chemical induction have reduced viability, which produces ... Xiaodong Yuan, Kailuan General Hospital, Hebei United ...
Breaking Biology News(10 mins):Molecular snapshots of oxygen formation in photosynthesis 2
... with colleagues from the Botswana National Museum shed new ... to southern Africa and from where. A domestic cow ... from a site at Toteng, located in the Kalahari ... Accelerator Mass Spectrometry (AMS) radiocarbon technique, provides the oldest ...
... found that the two primary areas of the human ... cortex used in higher-level thought undergoes more extensive changes ... such as heartbeat, breathing and balance. Their work, based ... of human and chimpanzee brains, also shows that the ...
... first time used gene therapy to successfully treat heart ... model that is genetically susceptible to a human muscular ... journal Circulation, the authors say that this is the ... the body. , "Previous attempts at systemic gene therapy ...
Cached Biology News:Human cerebellum and cortex age in very different ways 2Gene therapy reverses genetic mutation responsible for heart failure in muscular dystrophy 2Gene therapy reverses genetic mutation responsible for heart failure in muscular dystrophy 3Gene therapy reverses genetic mutation responsible for heart failure in muscular dystrophy 4
(Date:7/11/2014)... July 11, 2014 , Not for ... into or from any jurisdiction where to do so would ... Shire plc ("Shire" or the "Company") (LSE: SHP, ... afternoon.  Shire confirms it has held a meeting with representatives ... Shire without the prior agreement or approval of AbbVie. ...
(Date:7/11/2014)... , July 11, 2014 /CNW/ - Sunovion Pharmaceuticals ... APTIOM TM (eslicarbazepine acetate) for use as a ... in patients with epilepsy who are not satisfactorily controlled ... for use in patients under 18 years of age. ... common neurological disorders and according to Epilepsy Canada, it ...
(Date:7/10/2014)... (PRWEB) July 10, 2014 Product ... in very low abundance and are often “lost ... and time-consuming. , Join presenters Dr. Rowel Tobias, ... Dr. John Anders, Head of Quality at Nanotherapeutics, ... approach that can speed detection and quantitation while ...
(Date:7/10/2014)... 2014 Unraveling life’s mysteries can intrigue, ... Archer Family purchased a DNA test to ... up with a lifetime of memories, sharing, and closeness. ... members’ DNA genuinely brought the family closer together. ... into genetic history and prior to taking the ...
Breaking Biology Technology:Shire plc - Statement re: Media Speculation 2Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 2Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 3Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 4Novel Ms Techniques Speed Detection of Biopharmaceutical Product and Process Impurities, New Webinar Hosted by Xtalks 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5
... Helena Rojas to Director of Global Business Development Operations , ... ... Ltd., a leading provider of multilingual localization, testing and outsourced software ... to Vice President of Global Business Development and Helena Rojas to ...
... China, March 4 /PRNewswire-Asia-FirstCall/ -- Mindray Medical,International Limited ... manufacturer and,marketer of medical devices worldwide, today announced ... Officer of the Company effective as of May ... step down from the role of Chief,Financial Officer ...
... 4 The Healthcare practice at Frost ... 2009 Quarterly Analyst Briefing Presentation on the North ... March 5, 2009 at 10:00 a.m. PST. (Logo: ... growth and is experiencing several notable trends, such ...
Cached Biology Technology:Localization and Translation Leader CSOFT International Ltd. Recognizes Efforts of Two Key Members of its Business Development Team 2Localization and Translation Leader CSOFT International Ltd. Recognizes Efforts of Two Key Members of its Business Development Team 3Mindray Appoints Mr. Ronald Ede as Chief Financial Officer 2Mindray Appoints Mr. Ronald Ede as Chief Financial Officer 3Frost & Sullivan's Biopharmaceuticals Market Briefing to Address the Use of Embryonic Stem Cells 2
These 22x40mm rectangular No.1 Corning cover glasses are made from No. 0211 zinc titania glass and are 0.16 to 0.19mm thick. • Approx. Pcs Oz : 73...
The model 55D Rocking Shaker provides the same Reliable quality as the 55S, but double the value. The 55D gives you an additional platform with a height of 3.25 in....
... rolled steel with stove enamel coated (RAL 7035 ... Front, back and side windows ... lamps Internal adjustable tempered glass shelf ... Lighting 600 lux ...
... Shaker provides the exact agitation needed ... very slow to fast speed and ... a gentle wave motion that lifts ... membranes to achieve faster, more uniform ...
Biology Products: