Navigation Links
Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
Date:9/26/2008

PHILADELPHIA - Biophysicists at the University of Pennsylvania have used 3,200 computer processors and long-established data on cholesterol's role in the function of proteins to clarify the mysterious interaction between cholesterol and neurotransmitter receptors. The results provide a new model of behavior for the nicotinic acetylcholine receptor, a well studied protein involved in inflammation, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy, the effect of general anesthetics and addiction to alcohol, nicotine and cocaine.

Moreover, the results apply to closely related receptors that bind serotonin and GABA, which are neurotransmitters directly involved in regulation of mood and sleep.

The findings have broad implications for, among other fields, pharmacology. Drug development in this arena has to take into account the structure and chemical makeup of this receptor, both of which researchers now say were incomplete. Drugs acting on the receptor have been thought to interact with the protein as though it were isolated.

Now, researchers believe that drugs binding to the receptor not only interact with amino acids the building blocks of the protein receptor but also cholesterol tucked away within the protein. The shift in thinking transforms the understanding of this receptor in many ways, from shape and structure to its interaction with its environment and its response to neurotransmitters. The new model should spark a reexamination of several decades of research on the receptor's structure and function.

Researchers demonstrated that the receptor, also know as nAChR, contains internal sites capable of containing cholesterol which serve to stabilize the protein's structure. Furthermore, molecular simulations revealed that both surface sites and deeply buried sites within the protein require cholesterol, which directly supports contacts between the agonist-binding domain and the pores that are thought to
'/>"/>

Contact: Jordan Reese
jreese@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Iowa State wins $18.5M grant to create NSF Center for Biorenewable Chemicals
2. Tel Aviv University researchers create new stem cell screening tool
3. Researchers devise means to create blood by identifying earliest stem cells
4. Caltech scientists create DNA tubes with programmable sizes for nanoscale manufacturing
5. Engineers create bone that blends into tendons
6. Researchers create safer alternative to heparin
7. MSU to create genomic clearinghouse for biofuel crops
8. Gladstone scientists create Wikipathways to foster research collaboration
9. Engineers create 3-D model to help biologists combat blue tongue virus
10. UT Southwestern researchers create molecule that nudges nerve stem cells to mature
11. MIT creates new material for fuel cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
(Date:11/21/2014)... SAN JOSE, Calif. , Nov. 20, 2014 /PRNewswire/ ... a global leader in microcontroller (MCU) and touch technology ... digital temperature sensors with the widest V ... family delivers higher temperature accuracy and faster I 2 ... nonvolatile registers and serial EEPROM memory making them ideal ...
(Date:11/18/2014)... , Nov. 18, 2014   EyeLock ... authentication solutions, and MorphoTrust USA (Safran), ... services, today announced a strategic partnership to offer ... motor vehicle administration (MVA), airport screening and financial ... identity-related solutions, MorphoTrust serves consumers through a nationwide ...
(Date:11/10/2014)... Laundry detergent pods began appearing on U.S. store shelves ... growing numbers ever since. The small packets can be ... measure out a liquid or powder. The convenience, though, ... new study from researchers at Nationwide Children,s Hospital found ... received reports of 17,230 children younger than 6 years ...
Breaking Biology News(10 mins):Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3Study finds laundry detergent pods, serious poisoning risk for children 2
... in the first course of preschool lunch could be a ... to Penn State nutrition researchers. , "We have shown that ... adults to eat more of the foods that are high ... Helen A. Guthrie Chair of Nutritional Sciences. Rolls and ...
... and skin cancer may have a new use in boosting ... such as hepatitis C and HIV (the AIDS virus). These ... journal. John Pesce and colleagues at the Naval ... weakened or inactivated viruses or bacteria have had enormous success ...
... The International Serious Adverse Events Consortium (SAEC) announced today ... novel, international research consortium, which is working to identify ... at risk for a range of serious drug-related adverse ... will use Cerner Discovere, Cerner,s web-based research platform, to ...
Cached Biology News:First course of veggies may appeal to hungry preschoolers 2Cerner and ISAEC to collaborate on genetic studies of drug-induced serious adverse events 2
(Date:11/24/2014)... Belgium , Nov. 24, 2014 VolitionRx ... developing diagnostic tests for cancer and other conditions, today announced ... presented at the Science for Business BioWin Day 2014, being ... . The data come from VolitionRx,s lung cancer pilot study, ... of the Centre Hospitalier Universitaire (CHU) de Liege in ...
(Date:11/24/2014)... Continental Clinical Solutions, LLC (Continental) ... trials at its mid-Atlantic late-phase research facility, located ... with the idea of closing patient disparities in ... medical advances," said Continental's CEO, Saleh Stevens ... immortal cell line of Henrietta Lacks, dubious ethical ...
(Date:11/24/2014)... Senior Vice President, General Manager for Clinical ... acumen Elsevier , a world-leading provider ... congratulates Diane Bartoli , Senior Vice President and ... Solutions, for being recognized in the 13 th ... Profiles in Diversity Journal ® . ...
(Date:11/22/2014)... (PRWEB) November 21, 2014 Prominent ... investors will gather on December 3rd at Genetic ... Conferences series. GeneticRx will take place at the ... School and will discuss the present and future ... exon skipping, and gene editing—as well as the ...
Breaking Biology Technology:VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 3VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 4VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 5VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 6At Continental Clinical Solutions, CEO Saleh Stevens Focuses on Diversity in Clinical Trial Recruitment at Maryland Site 2At Continental Clinical Solutions, CEO Saleh Stevens Focuses on Diversity in Clinical Trial Recruitment at Maryland Site 3Elsevier Clinical Solutions' Diane Bartoli Featured In Profiles in Diversity Journal's 13th Annual Women Worth Watching Issue 2Elsevier Clinical Solutions' Diane Bartoli Featured In Profiles in Diversity Journal's 13th Annual Women Worth Watching Issue 3Pioneering Academics and Key Industry Leaders to Discuss Rare Diseases and the Emergence of New Genetic Medicines at Genetic Rx on December 3rd 2
... , Milwaukee Johnson Controls plans ... company that will pay approximately 330 million Euros, or $430 ... France. Johnson Controls bought it in 2001 from another French ... 350 million Euros. , SBC Foundation donates $1 million to ...
... truly protected global trademark is worth a ton in gold. ... iconic personality with a top-level protection plan and equipped with ... face it; such a name is worth a hundred times ... factories and all the stacking chimneys combined. Just ask Sony, ...
... data from an experimental CIMSS satellite. Courtesy of ... something as big as the weather, the University of ... needed a bigger computer. , ,The institute has begun ... 3700 supercomputer offered by Silicon Graphics Inc. ...
Cached Biology Technology:Global branding is easy with global trademarks 2Global branding is easy with global trademarks 3Global branding is easy with global trademarks 4UW-Madison picks scalable SGI computer to simulate weather 2UW-Madison picks scalable SGI computer to simulate weather 3
... ProteinChip Antibody Capture Kit ... and optimization steps typically ... interactions. This kit enables ... of multiple antigens based ...
... Custom design, The Bioactive peptides are molecules ... a biological behaviour or activity which can ... pharmaceutical, diagnostic, chemical and agro-food applications. In ... modified peptides with superior properties for therapeutic ...
... This CLS number is ... to easily match Cornings product ... yet, please order under the ... contact customer service for assistance. ...
... Series Hybridization chambers with forced convection ... ambient up to 99.9 C / 212 F ... and reproducible results DS controller Timer ... with an accuracy of a tenth of a ...
Biology Products: