Navigation Links
Penn biologists identify a key enzyme involved in protecting nerves from degeneration
Date:3/30/2012

g-back fashion. Yet now WldS and Nmnat failed to prevent axon degeneration, suggesting that those proteins may act on and require the presence of axonal mitochondria to maintain healthy nerves in normal flies.

Flipping that scenario around, they looked to see what happened to the mitochondria of flies upon nerve injury. When they cut the wing nerve axons, the mitochondria rapidly disappeared. Yet they can largely preserve the mitochrondria by increasing expression of Nmnat.

Their results, taken together with the findings of other studies, suggest that Nmnat may stabilize mitochondria in some way in order to keep axons in a healthy state.

"We have some hope that these proteins or their activity may someday serve as drug targets or could provide the foundation for a therapeutic advance," Bonini said. "But right now, my hope is that the power of the fly model will open up a lot of new directions of research and new pathways that could be targets for development in the future."


'/>"/>

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Caltech biologists spy on the secret inner life of a cell
2. Biologists, educators recognize excellence in evolution education
3. Caltech geobiologists discover unique magnetic death star fossil
4. Biologists discover gene behind plant sex mystery
5. Queens University biologists find new environmental threat in North American lakes
6. Biologists learn structure, mechanism of powerful molecular motor in virus
7. Biologists discover link between CGG repeats in DNA and neurological disorders
8. Biologists solve mystery of black wolves
9. Cleaning up oil spills can kill more fish than spills themselves, say Queens biologists
10. Plant biologists discover gene that switches on essence of male
11. Two innovative University of Texas at Austin biologists become HHMI Early Career Scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... suite of perilous threats in today,s ocean. From ... change, fragile coral ecosystems are disappearing at unprecedented ... species of corals surrounding the island of Moorea ... their tropical environment: coral guard-crabs. New research from ... Station scientist Seabird McKeon and the museum,s predoctoral ...
(Date:9/29/2014)... gut bacteria called Clostridium ramosum , coupled with a ... is published this week in mBio , the online ... A research team from the German Institute of Human Nutrition ... including C. ramosum gained weight when fed a ... were less obese even when consuming a high-fat diet, ...
(Date:9/29/2014)... September 29: Between 1970 and 2010 populations of ... globe dropped 52 percent, says the 2014 Living ... (WWF). This biodiversity loss occurs disproportionately in low-income ... high-income countries. , In addition to the precipitous ... to other warning signs about the overall health ...
Breaking Biology News(10 mins):Smithsonian scientists discover coral's best defender against an army of sea stars 2Gut bacteria promote obesity in mice 2Half of global wildlife lost, says new WWF report 2
... This release is available in Spanish . ... emerald ash borer could mean improved traps for monitoring and ... of Agriculture (USDA) entomologist Allard Coss and his colleagues. ... part of a multidisciplinary team of scientists from USDA,s Agricultural ...
... WASHINGTON, April 7, 2011 Moms-to-be long have been ... staying fit during pregnancy is good for both mother and ... that exercising strengthens a fetus, heart control, many pregnant women ... up for prenatal yoga classes; others found new ways to ...
... WASHINGTON, April 7, 2011 Timing is everything. That,s ... created by the pancreas to break down food. When the ... reach the gut, where they get to work releasing and ... is wrong and the enzymes are activated too soon, they ...
Cached Biology News:Scientists exploit ash tree pest's chemical communication 2Physically active moms-to-be give babies a head start on heart health 2Physically active moms-to-be give babies a head start on heart health 3Findings may help keep pancreatic disease off the menu 2
(Date:10/1/2014)... New applications of structures and materials that ... nature over millennia are featured in a special ... in biophotonics in the October issue of the ... by SPIE, the international society for optics and photonics, ... articles are accessible via open access. , “Biomimetic and ...
(Date:10/1/2014)... (PRWEB) October 01, 2014 Slone ... Clinical Therapeutics, Healthcare IT, and Laboratory Testing industries, reported ... positions at the director level and above from July ... to stay on top of rapid breakthroughs in diagnostics, ... many diagnostic companies have been forced to fold, consolidate, ...
(Date:10/1/2014)... The U.S. Department of Labor has awarded ... as part of the Trade Adjustment Assistance Community College ... by the Department of Labor and Department of Education. ... E. Perez and Secretary of Education Arne Duncan announced ... to nearly 270 colleges across the country. , ...
(Date:10/1/2014)... Industry leaders from retail ... around the theme, ,Commercial Opportunities in the Era of ... Elsevier , a world-leading provider of scientific, ... a gathering of some of the industry,s most prominent ... today and in the future. The Elsevier ...
Breaking Biology Technology:Biomimetic and bioinspired materials enable new healthcare options, reports Journal of Biomedical Optics 2Biomimetic and bioinspired materials enable new healthcare options, reports Journal of Biomedical Optics 3Slone Partners Meets Growing Demand as Industry Focuses on Reimbursement & Regulation 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 3U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 4Elsevier Healthcare and Pharmaceutical Economics Conference 2014 To Convene Industry Leaders to Discuss Top Healthcare Business Issues 2Elsevier Healthcare and Pharmaceutical Economics Conference 2014 To Convene Industry Leaders to Discuss Top Healthcare Business Issues 3
... Feb. 21 Keryx Biopharmaceuticals,Inc. (Nasdaq: KERX ) ... at 8:30 a.m. EST to discuss the fourth quarter ... Michael S. Weiss, Chairman,and Chief Executive Officer of the ... results for this period in a press release to ...
... 13, 2008 at 9:00 am (Eastern) ... am (Pacific) / 9:00 pm (Beijing/Hong Kong), SHANGHAI, ... WX ) ("WuXi PharmaTech" or "the Company"), the ... announced that it will release unaudited,financial results for the ...
... 5% annually over the next five ... to Millennium Research Group, WALTHAM, Mass., Feb. 21 ... the US market for,fixed C-arm systems, comprising units used for ... in 2007 and will,rise to over $1.8 billion by 2012., ...
Cached Biology Technology:Keryx Biopharmaceuticals, Inc. to Hold Conference Call on Fourth Quarter and Year-End 2007 Financial Results on Monday, February 25, at 8:30 A.M. EST 2WuXi PharmaTech Schedules Fourth Quarter and Full Year 2007 Earnings Release on Wednesday, March 12, 2008 2Fixed C-Arms Revolutionize Operating Room Environments 2
... The MBS Satellite Thermal ... and flexible solution for medium ... The MBS combines the latest ... friendly software and PC control, ...
45° Fixed Angle Rotor for use in the IEC Centra CL2, Centra CL3/CL3R, HN-SII, and the Centra-MP4/MP4R....
Glycerokinase; from Bacillus stearothermophilus...
...
Biology Products: