Navigation Links
Penn biologists identify a key enzyme involved in protecting nerves from degeneration
Date:3/30/2012

PHILADELPHIA - A new animal model of nerve injury has brought to light a critical role of an enzyme called Nmnat in nerve fiber maintenance and neuroprotection. Understanding biological pathways involved in maintaining healthy nerves and clearing away damaged ones may offer scientists targets for drugs to mitigate neurodegenerative diseases such as Huntington's and Parkinson's, as well as aid in situations of acute nerve damage, such as spinal cord injury.

University of Pennsylvanian biologists developed the model in the adult fruit fly, Drosophila melanogaster.

"We are using the basic power of the fly to learn about how neurons are damaged in acute injury situations," said Nancy Bonini, senior author of the research and a professor in the Department of Biology at Penn. "Our work indicates that Nmnat may be key."

The research was published in Current Biology. First author on the study is postdoctoral researcher Yanshan Fang, with additional contributions from postdoctoral researcher Lorena Soares and research technicians Xiuyin Teng and Melissa Geary, all of Penn's Department of Biology.

When a nerve suffers an acute injury -- as might be caused by a penetrating wound, for example, or a broken bone that damages nearby tissues -- the long projection of the nerve cell, called the axon, can become injured and degenerate. The process by which it disintegrates is known as Wallerian or Wallerian-like degeneration and is an active, orderly process.

Though this function of eliminating damaged nerve cells is crucial, biologists do not have a clear understanding of all of the molecular signaling pathways that govern the process.

Bonini's lab has previously focused on chronic neurodegenerative diseases but made this foray into acute nerve injury to determine if mechanistic overlaps exist between acute axon injury and chronic neurodegeneration. They first searched for an appropriate nerve tract to t
'/>"/>

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Caltech biologists spy on the secret inner life of a cell
2. Biologists, educators recognize excellence in evolution education
3. Caltech geobiologists discover unique magnetic death star fossil
4. Biologists discover gene behind plant sex mystery
5. Queens University biologists find new environmental threat in North American lakes
6. Biologists learn structure, mechanism of powerful molecular motor in virus
7. Biologists discover link between CGG repeats in DNA and neurological disorders
8. Biologists solve mystery of black wolves
9. Cleaning up oil spills can kill more fish than spills themselves, say Queens biologists
10. Plant biologists discover gene that switches on essence of male
11. Two innovative University of Texas at Austin biologists become HHMI Early Career Scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... available in German . ... built with the help of sophisticated assembly lines. Mobile assembly ... important part of these assembly lines. In the case of ... work stages arranged in a precise spatial and chronological sequence, ... line. , The creation of such an assembly line at ...
(Date:8/28/2014)... conserve biodiversity and more action is needed to ensure ... say. , Published in PLOS ONE , researchers ... Exeter, used meta-analysis - combining results from different studies ... research into these areas, to determine whether they actually ... Biological Sciences, said protecting an area from human exploitation ...
(Date:8/27/2014)... Aug. 27, 2014  WaferGen Bio-systems, Inc. (NASDAQ: WGBS) ... underwritten public offering of units of common stock and ... gross proceeds of $20 million, prior to deducting underwriting ... Company.  The shares and warrants are immediately separable and ... sold in the offering consists of 2,000 shares of ...
Breaking Biology News(10 mins):Nanoscale assembly line 2Nanoscale assembly line 3Protected areas proven to protect biodiversity 2WaferGen Bio-Systems Announces Successful Completion of Public Offering Raising $20 Million 2WaferGen Bio-Systems Announces Successful Completion of Public Offering Raising $20 Million 3
... Illinois at Chicago College of Pharmacy are attempting ... antipsychotic medication works in adults and children and ... a popular "atypical" antipsychotic medication, is used to ... disorder. , Jeffrey Bishop, assistant professor of ...
... With wheat stem sawfly natural enemies in demand, ... increasing their availability. , This fall, the ... mass-rearing parasitic wasps that attack wheat stem sawfly ... plants. The team includes entomologists David Weaver, master's ...
... tool developed at Cambridge University represents a breakthrough in ... Huntington's disease. , Researchers have developed an effective ... the disease, using an automated touch screen. It is ... more effectively the cognitive difficulties in other neurodegenerative disorders ...
Cached Biology News:Studies look at how genes affect antipsychotic drug response 2Rearing an army to save wheat 2Rearing an army to save wheat 3New technology to speed up research into Huntington's disease 2New technology to speed up research into Huntington's disease 3
(Date:8/28/2014)... MENLO PARK, Calif. , Aug. 28, 2014 ... company focused on developing novel mid- to late-stage ... raised $7.0 million in its first round of ... AshHill Biomedical Investments and Hercules Bioventures with participation ... biotech entrepreneur and pharmaceutical executive, Dr. Larry ...
(Date:8/28/2014)... Boston, MA (PRWEB) August 28, 2014 ... of wholesale construction materials, selected SoundConnect ... of their cloud based audio and web conferencing ... configured to support PrimeSource’s employees’ needs. SoundConnect ... technologies. , PrimeSource Building Products will be ...
(Date:8/27/2014)... Rhythm, a biopharmaceutical company developing peptide therapeutics that address ... disorders, announced today that it has filed a registration ... Exchange Commission (SEC) relating to the proposed initial public ... of shares to be offered and the price range ... Citigroup and Cowen and Company will act as ...
(Date:8/27/2014)... The Global and China Trifluoroacetic Acid Industry is ... of the Trifluoroacetic Acid industry in Global and China. ... industry, including definitions, applications and industry chain structure. Global ... with a focus on history, developments, trends and competitive ... and Chinese situation is also offered. , The report ...
Breaking Biology Technology:Armetheon Completes $7.0 Million Series A Financing 2Armetheon Completes $7.0 Million Series A Financing 3PrimeSource Chooses SoundConnect as Collaboration Provider 2Rhythm Files Registration Statement for Proposed Initial Public Offering 2Trifluoroacetic Acid Industry (Asia, Europe, North America, ROW) Analysis Report Now Available at ReportsnReports.com 2
... In a paper published this week in Science , ... and Professor Konstantin Novoselov has literally opened a third dimension ... prove the missing link for graphene to become the next ... is a remarkable material with endless unique properties, from ...
... 2012 InterMune, Inc. (NASDAQ: ITMN ) today ... year 2011 financial results at the close of the U.S. ... and webcast will be hosted by InterMune at 4:30 p.m. ... others may participate in the conference call by dialing 800-891-8257 ...
... Hudson, President and Scientific Director of The Ontario Institute ... to develop a framework for the implementation of personalized ... aims to integrate genomics research into everyday clinical practice, ... care for patients. Published in the journal ...
Cached Biology Technology:Graphene electronics moves into a third dimension 2InterMune to Release Fourth Quarter and Full Year Financial Results on February 9 2New Study Building Framework to Bring Personalized Medicine to the Clinic 2New Study Building Framework to Bring Personalized Medicine to the Clinic 3
Mouse monoclonal [SPM325] to Xanthine Oxidase, prediluted ( Abpromise for all tested applications). Antigen: C terminal 358 amino acid fragment of human xanthine oxidase. Entrez Gene ID: 749...
Rab1A...
Drugs and NO-drug Rat Anti-conjugated Acetyl Salicylic Acid Polyclonal Antibody...
Applications: Beadlyte® assay Stability: 2 years at 4°C (lyophilized) or 6 months at -20°C (rehydrated) ...
Biology Products: