Navigation Links
Penn biologists explain how organisms can tolerate mutations, yet adapt to environmental change
Date:1/20/2010

PHILADELPHIA - Biologists at the University of Pennsylvania studying the processes of evolution appear to have resolved a longstanding conundrum: How can organisms be robust against the effects of mutations yet simultaneously adaptable when the environment changes?

The short answer, according to University of Pennsylvania biologist Joshua B. Plotkin, is that these two requirements are often not contradictory and that an optimal level of robustness maintains the phenotype in one environment but also allows adaptation to environmental change.

Using an original mathematical model, researchers demonstrated that mutational robustness can either impede or facilitate adaptation depending on the population size, the mutation rate and a measure of the reproductive capabilities of a variety of genotypes, called the fitness landscape. The results provide a quantitative understanding of the relationship between robustness and evolvability, clarify a significant ambiguity in evolutionary theory and should help illuminate outstanding problems in molecular and experimental evolution, evolutionary development and protein engineering.

The key insight behind this counterintuitive finding is that neutral mutations can set the stage for future, beneficial adaptation. Specifically, researchers found that more robust populations are faster to adapt when the effects of neutral and beneficial mutations are intertwined. Neutral mutations do not impact the phenotype, but they may influence the effects of subsequent mutations in beneficial ways.

To quantify this idea, the study's authors created a general mathematical model of gene interactions and their effects on an organism's phenotype. When the researchers analyzed the model, they found that populations with intermediate levels of robustness were the fastest to adapt to novel environments. These adaptable populations balanced genetic diversity and the rate of phenotypically penetrant mutati
'/>"/>

Contact: Jordan Reese
jreese@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

Page: 1 2

Related biology news :

1. Biologists merge methods, results from different disciplines to find new meaning in old data
2. New handbook for biologists who need more competence or confidence in statistics
3. Biologists discover bacterial defense mechanism against aggressive oxygen
4. Beyond genomics, biologists and engineers decode the next frontier
5. Biologists, educators recognize excellence in evolution education
6. NIMBioS hosts tutorial on optimal control and optimization for biologists
7. Biologists discover death stench is a universal ancient warning signal
8. UTSA plant biologists publish where their peers are -- on the Web
9. Microbiologists find defense molecule that senses respiratory viruses
10. Geobiologists propose that the earliest complex organisms fed by absorbing ocean buffet
11. Biologists rediscover endangered frog population
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2014)... 2014 Increased emphasis on product quality, ... testing and inspection technologies. The convergence of industries ... range of innovative test solutions. This trend is ... which is generally more inclined towards communication, media ... strategies of test equipment vendors will cater to ...
(Date:11/21/2014)... 2014 According to a new ... (Video, RFID, Access Control, Intrusion Detection, Parking Management, Under ... Component Service Geography - Global Forecasts to 2020", published ... to be around $25 Billion in 2014 and is ... a CAGR of 8.69%. Browse 116 market ...
(Date:11/18/2014)... , Nov. 18, 2014  The Secure Identity ... Association today jointly announce the formation of The ... of its Identity and Biometric Entry and ... Framework received official support from BORDERPOL, the international ... improve and provide expertise regarding border security, traveler ...
Breaking Biology News(10 mins):Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3
... Barbara, Calif.) By determining simple guidelines, researchers at ... (SSLEC) have made it possible to optimize phosphors ... for brighter, more efficient lights. "These guidelines should ... a rational rather than trial-and-error manner," said Ram Seshadri, ...
... stress, some people seem to lose their appetite while others ... wisdom tells us that stress eaters are the ones who ... that stress eaters show a dynamic pattern of eating behavior ... published in Psychological Science , a journal of the ...
... State Secretary for Education, Research and Innovation, Dr ... for the establishment of ELIXIR, the European Life ... the time when five Member States will have ... force. The Swiss government has committed to investing ...
Cached Biology News:Breakthrough research produces brighter, more efficiently produced lighting 2Breakthrough research produces brighter, more efficiently produced lighting 3Stress eaters may compensate by eating less when times are good 2Switzerland signs the ELIXIR consortium agreement and contributes €35 million 2
(Date:12/24/2014)... 23, 2014 According to Ross Selinger, President ... of ITRA Global, the national office market continues to be ... This is evidenced by the third quarter’s surprising 3.9% GDP, ... Low energy costs have held inflation down and the Fed ... the housing market remaining soft. , This solid economic news ...
(Date:12/24/2014)... 2014 The report expects global cell ... 2019. It also provides a carefully analyzed data about ... for the market. , Full Copy of Report @ ... global market for cell expansion will keep witnessing growth ... this growth to be driven by rapid technological advancements, ...
(Date:12/24/2014)... Dec. 23, 2014 Vermillion, Inc. (Nasdaq: ... gynecologic disease, announced today that investors including Oracle ... Fund LLC and several Vermillion directors have agreed ... of Vermillion,s common stock and warrants to purchase ... private placement.  Under the terms ...
(Date:12/24/2014)... Fla. , Dec. 23, 2014  Rock Creek ... that it has filed a Clinical Trial Application (CTA) ... Healthcare products Regulatory Agency (MHRA) seeking regulatory approval to ... lead molecule, Anatabine Citrate. Contingent on the ... conduct a Phase I trial to assess the safety, ...
Breaking Biology Technology:ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 2Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 3
... Field Moving Toward Genotype-Guided Psychotropic TherapySAN FRANCISCO, May ... Genomas, and Director of Genetics Research at Hartford ... Psychiatry at the Mayo Clinic will co-chair a ... for Depressive Disorders ," at the annual meeting ...
... Austria, May 21 EUCODIS Bioscience, a company,developing, ... the,chemical industry, announced today that it has entered ... Danisco. Under the terms of the,agreement, EUCODIS Bioscience ... recombination" to the development of an optimized,version of ...
... Support the Global R&D and Healthcare CommunityPHILADELPHIA and LONDON, ... the global healthcare community working to prevent and address ... outbreak, the Healthcare and Science business of Thomson Reuters, ... and professionals, today announced the free availability of its ...
Cached Biology Technology:Genomas and Institute of Living Among Organizers of Pharmacogenetics Symposium at 2009 Annual Meeting of the American Psychiatric Association 2EUCODIS Bioscience Signs Research Agreement With Genencor 2Thomson Reuters Makes Disease Briefing on Influenza Covering H1N1 (Swine Flu) Publicly Available 2Thomson Reuters Makes Disease Briefing on Influenza Covering H1N1 (Swine Flu) Publicly Available 3
... Tetrad thermal cycler expands the envelope ... DNA Engine cycler. It ... a footprint only twice the size, ... that run massive quantities of reactions, ...
... tube gel adaptors, 24 glass tubes (1.5 ... stoppers. The PROTEAN II xi cell and ... versatility to perform a variety of separations,* ... native, preparative, and gradient PAGE as well ...
... DNA Engine Tetrad 2 thermal cycler ... units (sample-holder, heat-pump assemblies), which hold ... A Pentium-class computer drives an advanced ... sample, and lid temperatures. Peltier heat ...
Printer paper for Model 680 series readers is used with the thermal printers of the Model 680 and Model 680 XR microplate readers. Supplied as 2 rolls....
Biology Products: