Navigation Links
Penn biologists determine microRNA activity is suppressed in mouse ovum
Date:2/3/2010

PHILADELPHIA - Biologists at the University of Pennsylvania studying oocytes in mice, the immature egg cells necessary for sexual reproduction, have demonstrated an unusual behavior in microRNA, or miRNA, activity that may be the first event in reprogramming the differentiated oocyte into pluripotent blastomeres of the embryo. MicroRNAs are a member of the family of small RNAs, the so-called dark matter of the biological world.

MicroRNAs imperfectly pair with untranslated regions of RNA and mediate translational repression and mRNA degradationhallmarks of the gene expression process. The Dicer enzyme, which generates small RNAs in the miRNA and RNA interference pathways, is essential for meiotic maturation of mouse oocytes.

The scientists found that the mRNA population in oocytes lacking Dicer was not enriched in miRNA binding sites, implicating a weak impact of miRNAs on regulating mRNA stability. To explore further this possibility, the scientists injected a reporter transcript, a message RNA that is not a normally present in the oocyte but contained sequences that would interact with miRNAs in the oocyte. In somatic cells, such a message would be degraded and suppressed by micro RNA. However, in oocytes, there is minimal translational repression and no degradation of the message. The finding that this pathway does not operate in oocytes is most surprising because miRNAs are implicated in controlling cell differentiation.

The data, according to researchers, presents a puzzling paradox. "Although mouse oocytes produce miRNAs, their mRNA targets are poorly repressed," said Richard Schultz, associate dean for the natural sciences and the Charles and William L. Day Distinguished Professor of Biology in Penn's School of Arts and Sciences. "Reducing miRNA activity during oocyte growth may have two roles. First, the low activity of miRNA-mediated mRNA degradation, perhaps linked to the absence of P bodies (structures that are implicated as
'/>"/>

Contact: Jordan Reese
jreese@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

Page: 1 2

Related biology news :

1. CCNY biologists identify new spiny pocket mouse species
2. Penn biologists explain how organisms can tolerate mutations, yet adapt to environmental change
3. Biologists merge methods, results from different disciplines to find new meaning in old data
4. New handbook for biologists who need more competence or confidence in statistics
5. Biologists discover bacterial defense mechanism against aggressive oxygen
6. Beyond genomics, biologists and engineers decode the next frontier
7. Biologists, educators recognize excellence in evolution education
8. NIMBioS hosts tutorial on optimal control and optimization for biologists
9. Biologists discover death stench is a universal ancient warning signal
10. UTSA plant biologists publish where their peers are -- on the Web
11. Microbiologists find defense molecule that senses respiratory viruses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... a joint venture between The University of Texas at ... Science Center at San Antonio, has selected the winners ... Boice from UTSA and Lei Huang from the Health ... "Novel engineered ferritins for tracking and protecting neural stem ... is focused on finding a treatment for stroke through ...
(Date:7/30/2014)... study of dominance in female baboons suggests that the route ... mom, and to have lots of supportive sisters. , A ... strength, but by the rank of her mother - the ... be. For this reason, dominance rank in female baboons is ... mothers are guaranteed a good spot in the pecking order, ...
(Date:7/30/2014)... A team of biologists, led by Clemson University associate ... marine pest that will pave the way for novel ... bio-adhesives for medical and industrial applications. , The team,s ... examined the last larval stage of barnacles that attaches ... natural, possibly polymeric material that acts as an underwater ...
Breaking Biology News(10 mins):Supportive moms and sisters boost female baboon's rank 2Supportive moms and sisters boost female baboon's rank 3Study: Marine pest provides advances in maritime anti-fouling and biomedicine 2
... almost unbearably complex. Humans and mice, frogs and flies ... sequences during their relentless march from embryo to death. ... proteins behind the genomic wizard,s screen have a powerful ... the Stanford University School of Medicine. Until now, ...
... Researchers from the University of Leeds, UK, the Charit ... for Molecular Medicine (MDC) in Berlin, Germany, have discovered ... studies have identified how ,junk, DNA promotes the growth ... Constanze Bonifer (University of Leeds) and Dr Stephan Mathas ...
... , VANCOUVER, BRITISH COLUMBIA Although there is no ... in several genes are associated with the developmental brain ... may be involved with autism. Investigators will present ... Academic Societies (PAS) annual meeting in Vancouver, British Columbia, ...
Cached Biology News:New Stanford tool enables wider analyses of genome 'deep sequencing' 2New Stanford tool enables wider analyses of genome 'deep sequencing' 3'Junk DNA' drives cancer growth 2Study adds to evidence that autism has genetic basis 2
(Date:7/30/2014)... Toronto, Canada (PRWEB) July 30, 2014 ... been available in health services research for a ... an upswing in interest regarding the use of ... actual practice conditions. , By combining today’s powerful ... in the digital era, ‘big data’ holds significant ...
(Date:7/30/2014)... July 30, 2014 With the ... of personal health expenditure as well as the ... system, China diagnostic reagent industry has been developing ... 90%. In 2013, Chinese in vitro diagnostics market ... came from in vitro diagnostic reagents. , ...
(Date:7/30/2014)... (PRWEB) July 30, 2014 Yuma ... facility and complementary therapies brings comprehensive cancer care ... state-of-the-art Yuma Regional Cancer Center has officially opened. ... the program includes services such as open, semi-private ... therapy, American Cancer Society Resource Center, hematology, rehabilitation ...
(Date:7/30/2014)... DIEGO , July 30, 2014   Epic ... designs and develops novel diagnostics to personalize and advance ... appoint of Gregory T. Lucier as chairman ... chairman and CEO of Life Technologies (formerly Invitrogen). Mr. ... as Epic commercializes its circulating rare cell analysis platform ...
Breaking Biology Technology:Leveraging ‘Big Data’ - Methodological Considerations in Health Services Research, New Webinar Hosted by Xtalks 2China Diagnostic Reagent Industry Report, 2013-2016 | Researchmoz 2China Diagnostic Reagent Industry Report, 2013-2016 | Researchmoz 3Sate-of-the-Art Yuma Regional Cancer Center Officially Opens 2Epic Sciences Appoints Greg Lucier as Chairman of the Board of Directors 2Epic Sciences Appoints Greg Lucier as Chairman of the Board of Directors 3
... Preparing for The Joint,Commission survey process within the ... internal services used to support patient,care, including all ... a result, a,healthcare institution must be prepared for ... direction and to involve any staff member. EH&E ...
... England, June 10 The Board of,Directors of ... global specialty,biopharmaceutical company, announces today that Graham Hetherington ... Executive Board Director on,1st July 2008., Graham ... senior financial,roles having most recently held positions as ...
... Calif., June 10 ,CryoLife, Inc. (NYSE: CRY ), ... that they have received a CE Mark for the ... endoscopic,browplasty or brow lift, a reconstructive plastic surgery procedure. ... in the European Community,(EU)., BioGlue will be distributed ...
Cached Biology Technology:White Paper Helps Hospitals Prepare Staff for Joint Commission Environment of Care Interview Sessions 2Graham Hetherington Appointed Chief Financial Officer and Board Director at Shire 2Graham Hetherington Appointed Chief Financial Officer and Board Director at Shire 3CryoLife's BioGlue(R) Surgical Adhesive Receives European Approval for use in Browlift Cosmetic and Reconstructive Plastic Surgery 2CryoLife's BioGlue(R) Surgical Adhesive Receives European Approval for use in Browlift Cosmetic and Reconstructive Plastic Surgery 3CryoLife's BioGlue(R) Surgical Adhesive Receives European Approval for use in Browlift Cosmetic and Reconstructive Plastic Surgery 4
Anti-BAR Immunogen: Peptide of aa 3-21 from human Bar Available Date: 38226...
... the HECT protein, E6-AP and ... suggests that this E2 is ... of non-""N-end rule"" protein substrates ... proteins as well as the ...
Anti-Mouse D011.10 TCR, Biotin (Clone KJ1-26) (mouse IgG2a)...
Reacts with methylated DNA from plants and vertebrates...
Biology Products: