Navigation Links
Penn Vet study reveals a promising new target for Parkinson's disease therapies
Date:1/18/2013

against MPTP toxicity. The authors now show that mitochondrial CYP2D6 can effectively metabolize MPTP to toxic MPP+, indicating a possible connection between mitochondrial CYP2D6 and Parkinson's.

"About 80 percent of the human population has only one copy of CYP2D6, but the other 20 percent has variant forms of it and some populations have multiple copies," Avadhani said. "In those people, the activity of mitochondrial CYP2D6 can be high, and there have been correlations between these variants and the incidence of Parkinson's disease."

Working with primary neuronal cells in culture, the researchers showed that mitochondrial CYP2D6 could actively oxidize MPTP to MPP+. When they introduced compounds that selectively inhibited the activity of CYP2D6, this conversion process was largely halted. Neuronal degeneration was also greatly reduced.

"If we add MPTP to dopamine-sensitive neurons and also add a CYP2D6 inhibitor, we see marked protection of the neuronal function," Avadhani said. "We believe this is a paradigm shift in how we think about the mechanism of Parkinson's."

A number of MAO-B inhibitors used in the clinical setting for treating Parkinson's disease have unwanted side effects. A mitochondrial CYP2D6 inhibitor represents a much more specific and direct target and may thus cause fewer troublesome side effects.

To take the next step with this finding, Avadhani and his colleagues are developing an animal model and using stem cells to confirm the significance of mitochondrial CYP2D6's role in the development of Parkinson's symptoms.


'/>"/>

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. Abortions are safe when performed by advanced practice nurses and physician assistants, study shows
2. Study offers new insights into the mechanics of muscle fatigue
3. Recent study suggests bats are reservoir for ebola virus in Bangladesh
4. Privacy a problem for mothers of newborns in neonatal intensive care units, CWRU study finds
5. Study finds a new culprit for epileptic seizures
6. Researcher awarded $5.08 million to study oilseed camelina as biofuel feedstock
7. International study: Where theres smoke or smog, theres climate change
8. Born to lead? Leadership can be an inherited trait, study finds
9. CU-led study shows pine beetle outbreak buffers watersheds from nitrate pollution
10. UCI study reveals why Down syndrome boosts susceptibility to other conditions
11. Multiple sclerosis study reveals how killer T cells learn to recognize nerve fiber insulators
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... to a whale entangled in fishing gear, scientists showed ... whale,s diving and swimming behavior. The monitoring revealed how ... depletes their energy as they drag gear for months ... , The scientists in this entanglement response suction-cupped a ... North Atlantic right whale called Eg 3911. The Dtag, ...
(Date:5/21/2013)... of pharmaceuticals can both prevent and treat Alzheimer,s Disease ... ligands," are currently used for certain types of neuroimaging. ... in young adult mice when pathology was at an ... quite severe," said lead researcher Christian Pike of the ... of pathology and improved behavior at both ages." , ...
(Date:5/21/2013)... in pharmacies and health stores, phosphatidylserine is a ... soy. Proven to improve cognition and slow memory ... experiencing memory impairment. Now a team headed by ... Tel Aviv University,s Department of Human Molecular ... improves the functioning of genes involved in degenerative ...
Breaking Biology News(10 mins):Study reveals how fishing gear can cause slow death of whales 2Study reveals how fishing gear can cause slow death of whales 3Drugs found to both prevent and treat Alzheimer's disease in mice 2Common food supplement fights degenerative brain disorders 2
... international team of scientists has used gene therapy in ... normal movements in monkeys and rats with a drug-induced ... in the scientific publications Brain and The Journal of ... at its onset and another strategy to treat the ...
... 2005 workshop in Tunisia, supported by the European ... in improving health in countries bordering the Mediterranean ... importance of Euro-Mediterranean partnerships in order to capitalise ... particular following the mapping of the human genome ...
... Research Center are analyzing the surprising results of the first ... , From January 2000 to July 2004, rainfall was excluded ... the Tapajós National Forest, in Brazil. A total of 6 ... 6' clear plastic panels suspended 3 to 12 feet above ...
Cached Biology News:Gene therapy for Parkinson's disease moves forward in animals 2Gene therapy for Parkinson's disease moves forward in animals 3Gene therapy for Parkinson's disease moves forward in animals 4Measuring the impact of post-genomics on Mediterranean populations 2World's largest rainforest drying experiment completes first phase 2World's largest rainforest drying experiment completes first phase 3
(Date:5/23/2013)... May 23, 2013 VG Energy, an ... with DAK Renewable Research to conduct field trials ... VG Energy is a majority owned subsidiary of ... VG Energy,s exclusively licensed compound LipidMax selectively ... yield in plants, possessing a wide variety of ...
(Date:5/23/2013)... 23, 2013 Z Trim Holdings, Inc. (OTC ... a variety of industries, announced that Chef ... at this year,s National Restaurant Association ("NRA") NRA Show, ... of the Research Chefs Association.  Chef Ryan spoke on ... the Bad and the Ugly," joining four other prestigious ...
(Date:5/23/2013)... During the conduct of research involving ... principles of good clinical practice (GCP) and human ... Lim, Fellow, Clinical Development at Novartis Pharmaceuticals, will ... the International Conference on Harmonization (ICH) Guideline for ... the conduction of clinical trials ,     Apply ...
(Date:5/23/2013)... May 23, 2013 Bed bugs ... university had already confirmed it. Meanwhile, My Cleaning Products offered ... bug victims fight the pests without using harmful chemical elements. ... May 15, 2013, the affected building was actually a ... infested was said made on May 13 and bed bug ...
Breaking Biology Technology:VG Energy Enters into a Strategic Alliance with DAK Renewable Research for LipidMax Field Trials 2VG Energy Enters into a Strategic Alliance with DAK Renewable Research for LipidMax Field Trials 3Z Trim's Chef Erin Ryan sits on Expert Panel at NRA Show 2Z Trim's Chef Erin Ryan sits on Expert Panel at NRA Show 3Adhering to Good Clinical Practice, New Webinar Hosted by Xtalks 2Penn State Dorm Infested with Bed Bugs, My Cleaning Products Offers Complimentary Sample of Bed Bug Spray to Help Bed Bug Victims 2
... Ethanol Fuels, Inc. (OTC Bulletin Board: BFRE), a ... the production of ethanol from non-food cellulosic wastes, ... company and leading algal synthetic biology company, is ... compatibility with its renewable oil process to produce ...
... Science &,Technology division China and Science News announced today ... Summit" in Beijing on,June 2, 2009, at the Beijing ... a time when China has increased efforts to build ... competition for,academic talent among universities is a topic of ...
... May 25 Beactica AB, the Swedish,fragment-based drug ... an agreement with Cubist Pharmaceuticals, Inc. (Lexington, MA; ... will use its Sprint(TM) surface plasmon,resonance (SPR)-integrated drug ... of interest to Cubist. Financial terms of,the agreement ...
Cached Biology Technology:Solazyme Testing BlueFire Ethanol Cellulosic Sugars in Its Microalgae Renewable Oil Production Process 2Solazyme Testing BlueFire Ethanol Cellulosic Sugars in Its Microalgae Renewable Oil Production Process 3Elsevier's Science & Technology Division and Science News Partner to Organize the First "Attracting Academic Talent Summit" in Beijing 2Elsevier's Science & Technology Division and Science News Partner to Organize the First "Attracting Academic Talent Summit" in Beijing 3