Navigation Links
Penn Vet study reveals a promising new target for Parkinson's disease therapies
Date:1/18/2013

PHILADELPHIA With a new insight into a model of Parkinson's disease, researchers from the University of Pennsylvania School of Veterinary Medicine have identified a novel target for mitigating some of the disease's toll on the brain.

Narayan G. Avadhani, Harriet Ellison Woodward Professor of Biochemistry and chair of the Department of Animal Biology at Penn Vet, was the senior author on the research. Other department members contributing to the work included Prachi Bajpai, Michelle C. Sangar, Shilpee Singh, Weigang Tang, Seema Bansal and Ji-Kang Fang. Co-authors from Vanderbilt University are Goutam Chowdhury, Qian Cheng, Martha V. Martin and F. Peter Guengerich.

To study Parkinson's, researchers have commonly mimicked the effects of the disease in animals by giving them a compound known as MPTP, a contaminant of the illicit drug MPPP, or synthetic heroin. MPTP causes damage to brain cells that respond to the neurotransmitter dopamine, leading to problems in muscle control, including tremors and difficulty walking.

The common understanding of MPTP's mechanism was that it entered the brain and was eventually converted to the toxic compound MPP+ by the enzyme MAO-B, which is located on the mitochondria of non-dopaminergic (or dopamine-sensitive) neurons. Scientists believed MPP+ was carried by the action of specific transporters into dopaminergic neurons, where it inhibited mitochondrial function and led to cell death.

In the new study, published in the Journal of Biological Chemistry, the Penn-led team turned its attention to yet another molecule, known as mitochondrial CYP2D6, which until recently has been largely uninvestigated. Previous studies in the investigators' laboratory showed that CYP2D6, a protein that is predominantly localized to cells' endoplasmic reticulum, was also targeted to their mitochondria.

Unlike MAO-B, the endoplasmic reticulum-associated CYP2D6 was thought to have a protective effect
'/>"/>

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania
Source:Eurekalert

Page: 1 2

Related biology news :

1. Abortions are safe when performed by advanced practice nurses and physician assistants, study shows
2. Study offers new insights into the mechanics of muscle fatigue
3. Recent study suggests bats are reservoir for ebola virus in Bangladesh
4. Privacy a problem for mothers of newborns in neonatal intensive care units, CWRU study finds
5. Study finds a new culprit for epileptic seizures
6. Researcher awarded $5.08 million to study oilseed camelina as biofuel feedstock
7. International study: Where theres smoke or smog, theres climate change
8. Born to lead? Leadership can be an inherited trait, study finds
9. CU-led study shows pine beetle outbreak buffers watersheds from nitrate pollution
10. UCI study reveals why Down syndrome boosts susceptibility to other conditions
11. Multiple sclerosis study reveals how killer T cells learn to recognize nerve fiber insulators
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... developmental on-off switch for Streptomyces , a group ... the world,s naturally derived antibiotic medicines. , Their ... possible to manipulate this switch to make nature,s antibiotic ... 28 in Cell , found that a unique ... larger protein called BldD ultimately controls whether a bacterium ...
(Date:8/28/2014)... complex systems. Their infrastructure equipment requires ancillary sub-systems ... to supply fuel, and ICT systems for control ... is interconnected with a wider network and they ... scientists has studied various aspects of inter-network dependencies, ... in EPJ B by Gaihua Fu from Newcastle ...
(Date:8/28/2014)... is available in German . ... now built with the help of sophisticated assembly lines. Mobile ... an important part of these assembly lines. In the case ... various work stages arranged in a precise spatial and chronological ... the line. , The creation of such an assembly line ...
Breaking Biology News(10 mins):Small molecule acts as on-off switch for nature's antibiotic factory 2Small molecule acts as on-off switch for nature's antibiotic factory 3Inter-dependent networks stress test 2Nanoscale assembly line 2Nanoscale assembly line 3
... ARBOR, Mich. and PHOENIX, Ariz. As a key step ... profiles, the University of Michigan and the International Genomics Consortium ... usher in an age of personalized medicine. Called Paradigm, ... U-M Health System and IGC, two leaders in using genetic ...
... HOLLYWOOD, Calif., Aug. 16, 2012  Medbox, Inc. (Pinksheets: MDBX) ( ... interest about their Safe Storage and Access Lockers as other ... systems. "When a company as large as ... it helps educate the public about the usefulness and benefits ...
... of the International Society for Reef Studies, has published ... the Natural History Museum of Los Angeles County (NHM) ... mirabilis . The species was previously restricted to Pacific ... distant points in the Atlantic. Its presence near Brazilian ...
Cached Biology News:Creating a future of personalized medicine: U-M forms joint venture for DNA diagnostics 2Medbox Safe Storage and Access Lockers Gaining Popularity 2Invasive brittle star species hits Atlantic Ocean 2
(Date:8/29/2014)... 2014 Local veterinarian, Dr. Keith Clement, ... seeking candidates to participate in an investigational study of ... ultimate goal of this study is to determine if ... or two arthritically affected joints can help reduce pain ... for the current investigational study must be older than ...
(Date:8/29/2014)... Due to a misstatement posted by the ... Stem Cell Technology Center, LLC ( ASCTC ) was reported ... research that might benefit ALS patients. Because of ASCTC's ... cell technologies and therapeutic applications, FRC listed ASCTC as one ... donors who wish not to support research that requires the ...
(Date:8/29/2014)... Boston, MA, San Antonio, TX (PRWEB) August 29, ... audited, ISO 9001:2008 and ISO 13485:2003 certified, GAMP® ... it has been awarded an international Phase II ... patients with non-Hodgkin’s lymphoma. , Throughout this trial, ... services including, but not limited to, protocol and ...
(Date:8/28/2014)... August 28, 2014 Best Sanitizers, Inc., ... the food processing industry, is asking industry professionals to ... comparison of the E2 soap they’re currently using to ... Soap . Hand hygiene is critical to fighting ... processing environment. Six key criteria are identified to evaluate ...
Breaking Biology Technology:Burnt Hills Veterinary Hospital Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 2The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 3Intrinsic Imaging Awarded Phase II Clinical Trial to Assess New Treatment for Non-Hodgkin’s Lymphoma 2Best Sanitizers, Inc. Asks Food Industry Professionals: With Fall Harvest On the Way, Is Your E2 Hand Soap Up to the Task? 2
... Overview , ... complex protein mixtures using isotope coded affinity tags is to ... pairs on a spectrum generated by mass spectrometry. Because MALDI-TOF ... relative quantitation, it can be used to quickly screen the ...
... Communal and A. Royer, Girpa, Angers, France , ... Introduction , ... areas. These compounds have to be detected at trace level to ensure a ... from contaminated sites. , Among the analytical ...
... D. Garteiz, S. Din, and R. Morrow , ... Introduction , ... measurement down to 15 picograms of the cardiac glycoside, Digoxin, in human plasma ... are very thermally labile, ESI is preferred over a hot vaporization process like ...
Cached Biology Technology:Achieving Reliable Protein Quantitation Results Using ICAT Reagents, MALDITOF Mass Spectrometry, and Advanced Data Interpretation Tool 2Achieving Reliable Protein Quantitation Results Using ICAT Reagents, MALDITOF Mass Spectrometry, and Advanced Data Interpretation Tool 3Fast Analysis of Phenoxyacetic and Phenoxypropionic Herbicides in Vegetable Matrix by Negative Ion Electrospray LC/MS/MS 2Fast Analysis of Phenoxyacetic and Phenoxypropionic Herbicides in Vegetable Matrix by Negative Ion Electrospray LC/MS/MS 3Quantitation of Digoxin in Human Plasma Using Negative Ion Electrospray Ionization LC/MS 2Quantitation of Digoxin in Human Plasma Using Negative Ion Electrospray Ionization LC/MS 3
The strip cap tool is a used for properly seating 8- and 12-cap strips in microplates or strip tubes. A grooved channel on one side is designed to seat domed caps, while the flat edge on the opposite...
Experion Pro260 chips are the microfluidic chips used to perform protein analysis with the Experion automated electrophoresis system. Each chip has the capacity to run 10 protein samples. Supplied as...
...
...
Biology Products: