Navigation Links
Penn Researchers attach Lyme disease antibodies to nanotubes, paving way for diagnostic device
Date:3/26/2013

ures, such as olfactory receptors and DNA, to carbon nanotube-based devices.

Carbon nanotubes, rolled-up lattices of carbon atoms, are highly conductive and sensitive to electrical charge, making them promising components of nanoscale electronic devices. By attaching different biological structures to the exteriors of the nanotubes, they can function as highly specific biosensors. When the attached structure binds to a molecule, that molecule's charge can affect the electrical conduction of the nanotube, which can be part of an electrical circuit like a wire. Such a device can therefore provide an electronic read-out of the presence, or even concentration, of a particular molecule.

To get the electrical signal out of these nanotubes, the team first turned them into transistor devices.

"We first grow these nanotubes on what amounts to a large chip using a vapor deposition method, then make electrical connections essentially at random," Johnson said. "We then break up the chip and test all of the individual nanotube transistors to see which work the best."

In their recent experiment, Johnson's team attached antibodies that naturally develop in most animals that are infected with the Lyme disease bacterium to these nanotube transistors. These antibodies naturally bind to an antigen, in this case, a protein in the Lyme bacterium, as part of the body's immune response.

"We have a chemical process that lets us connect any protein to carbon nanotubes. Nanotubes are very stable, so we have a very reactive compound that binds to the nanotube and also has a carboxylic acid group on the other end. For biochemists, getting any kind of protein to bind to a carboxylic acid group is just child's play at this point, and we have worked with them to learn how to perform this chemistry on the side wall of nanotubes. "

After using atomic-force microscopy to show that antibodies had indeed bound to the exteriors of their nanotube
'/>"/>

Contact: Evan Lerner
elerner@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2015)... Calif. , July 9, 2015  Synaptics Inc. (NASDAQ: ... solutions, announced today that it will report financial results ... Thursday, July 30, 2015 after the close of market. ... analysts and investors at 2:00 p.m. PT (5:00 p.m. ... To participate on the live call, analysts ...
(Date:7/8/2015)... YORK , July 8, 2015 Summary ... globally, and the fourth most fatal, with a mortality ... The poor prognosis of pancreatic cancer patients has highlighted ... treatment, which is not being met by the current ... an array of products with varying molecule types and ...
(Date:7/7/2015)... June 30, 2015 ... the addition of the "Capacitive Fingerprint Sensors ... To this date, fingerprint sensing technology is ... fingerprint sensors are well developed. This patent landscape ... The domain of capacitive fingerprint sensors ...
Breaking Biology News(10 mins):Synaptics to Report Fourth Quarter, Fiscal Year 2015 Results on July 30 2Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 2Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 3Worldwide Capacitive Fingerprint Sensors Patent Landscape Market Report 2015-2020 - Main IP Holders include Seiko Epson, AuthenTec, Sony and STMicroelectronics 2
... NY and Stockholm, Sweden -- A team of researchers affiliated ... report in the current issue of Nature Methods ... a single cell -- a capability of relevance to everything ... cells in tumors and in healthy tissues that are not ...
... million people in Britain today may not know it, but ... herpesvirus 6 inherited from a parent. The study ... Leicester, is funded principally by the Medical Research Council (MRC), ... The research led by Dr Nicola Royle, Senior Lecturer ...
... LOUIS In a recent study published in ... professor of pharmacological and physiological science Michael Ariel, Ph.D., ... turtles who can retract their head deep into their ... eyes would operate like other animals with eyes on ...
Cached Biology News:A boost for cellular profiling 2New research on inherited herpesvirus may have implications for transplantation 2SLU researcher finds a turtle eye muscle adapts to deal with obstructed vision 2
(Date:7/29/2015)... ... 29, 2015 , ... G-CON Manufacturing, Inc., the leading prefabricated ... generation cell therapy POD® design. The 2nd generation portfolio not only delivers design ... POD® design. , “G-CON first offered our miniPOD CT product line to ...
(Date:7/29/2015)... MILWAUKEE, Wis. (PRWEB) , ... July 29, 2015 ... ... facility identification solutions, today announced its GHS Label Guide . To align ... Harmonized System (GHS), this guide includes explanations of label components, an example of ...
(Date:7/29/2015)... 29, 2015  Therapath Neuropathology ( www.Therapath.com ), ... with VA and Military Medical centers both domestically ... (ENFD) and Sweat Gland Nerve Fiber Density (SGNFD) ... https://therapath.com/skin ). Demonstration of a ... on punch skin biopsy is a highly sensitive ...
(Date:7/29/2015)... July 29, 2015  Indivior PLC (LON: INDV) today ... nasal spray was accepted and received Priority Review by ... treatment of opioid overdose. This naloxone nasal spray comes ... for optimal absorption into the nasal mucosa. 1 ... so individuals may be better equipped to help an ...
Breaking Biology Technology:G-CON Manufacturing Launches Their 2nd Generation Cell Therapy Cleanroom POD® 2G-CON Manufacturing Launches Their 2nd Generation Cell Therapy Cleanroom POD® 3Brady Announces a New GHS Label Guide 2Neuropathology services for VA and Military health systems 2Indivior PLC Announces FDA Acceptance of Naloxone Nasal Spray New Drug Application With Priority Review 2Indivior PLC Announces FDA Acceptance of Naloxone Nasal Spray New Drug Application With Priority Review 3Indivior PLC Announces FDA Acceptance of Naloxone Nasal Spray New Drug Application With Priority Review 4Indivior PLC Announces FDA Acceptance of Naloxone Nasal Spray New Drug Application With Priority Review 5
... managing liability in identity theft cases was spelled out ... Conference, and healthcare providers got a real sense of ... a hypothetical case of identity theft from an orthopedic ... demonstrated how much trouble healthcare organizations can find themselves ...
... look forward to writing this particular article with great anticipation! Why, ... have followed with eagerness as I grew up in the pharmaceutical ... was the juggernaut it is today). At Pfizer, we were all ... our company fared against our competition: had we moved up or ...
... - Amid reports that high net worth women ... businesses, Wisconsin's first angel fund focusing on investments in ... at the State Capitol. , ,The Wisconsin Women's Angel ... Angels Fund , will initially make available $2.3 million ...
Cached Biology Technology:Managing the nightmare of identity theft 2Managing the nightmare of identity theft 3Managing the nightmare of identity theft 4Leading global Big Pharma companies of 2005 2Leading global Big Pharma companies of 2005 3Leading global Big Pharma companies of 2005 4Leading global Big Pharma companies of 2005 5Leading global Big Pharma companies of 2005 6Leading global Big Pharma companies of 2005 7Leading global Big Pharma companies of 2005 8Angel fund to focus on women and minority businesses 2Angel fund to focus on women and minority businesses 3
... wide range of next-generation features into a ... standard for flexible laboratory solutions. It puts ... pipetting, dilution, dispensing, and integrations into ... and flexible as it is efficient and ...
... The mini incubation trays ... used to screen antigens that ... membrane. Each tray has eight ... channels that accommodate strips cut ...
... the process and you reduce the chance ... the CEQ 8000. Developed using Beckman Coulters ... in capillary electrophoresis technology, the CEQ 8000 ... This system automatically fills the capillary array ...
... standard electrophoresis hood is a ... systems. Placed on the transilluminator, ... place and provides a darkroom ... the lab bench. This 13 ...
Biology Products: