Navigation Links
Penn Medicine team reports on study of first 59 leukemia patients who received cell therapy
Date:12/7/2013

ew cells for each single engineered cell patients receive. Cells in the patient that do not express CD19 are left untouched by the modified T cells, which limits the prolonged, systemic side effects typically experienced during traditional cancer therapies that harm healthy tissue.

Treatment Prompts High Response Rates, Durable Remissions

Taken together, the newly announced results show promise for a range of tough-to-treat blood cancers. All study patients had exhausted conventional treatment options. In many cases, they were ineligible for bone marrow transplantation or declined that option due to the risks associated with the procedure, which carries at least a 20 percent mortality risk.

"We are tremendously excited about these results. About half of our CLL patients responded to this therapy, with most of them having several pounds of tumors eradicated by the genetically modified T cells," says study author David L. Porter, MD, the Jodi Fisher Horowitz Professor in Leukemia Care Excellence and director of Blood and Marrow Transplantation in Penn's Abramson Cancer Center, who will present the two CLL trial abstracts during the meeting. "We've now seen remissions lasting for more than three years, and there are clues that the T cells continue to kill leukemia cells in the body for months after treatment: Even in patients who had only a partial response, we often found that all cancer cells disappeared from their blood and bone marrow, and their lymph nodes continued to shrink over time. In some cases, we have seen partial responses convert to complete remissions over several months."

The research team is especially encouraged by the early results among ALL patients, since that disease progresses rapidly and is very deadly among those who relapse after standard treatments. About 85 percent of pediatric patients with the disease are cured with first-line therapies, but those whose cancers relapse and/or become refractory ha
'/>"/>

Contact: Holly Auer
holly.auer@uphs.upenn.edu
215-200-2313
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. Singapore joins global translational medicine network as Asia-Pacific hub
2. Penn Dental Medicine team identifies molecule critical to healing wounds
3. Sons of cocaine-using fathers may resist addiction to drug, Penn Medicine study suggests
4. Osteoarthritis medicine delivered on-demand
5. College of Veterinary Medicine researcher doubles down on deadly, infectious cat diseases
6. Ludwig scientist Richard D. Kolodner elected to the Institute of Medicine
7. Leader of smoking cessation and tobacco prevention efforts receives Institute of Medicines 2013 Lienhard Award
8. Institute of Medicine Elects 70 New Members, 10 Foreign Associates
9. Carnegie Mellon President Subra Suresh elected to Institute of Medicine
10. Institute of Medicine honors members for outstanding service
11. Wyss Institute core faculty member elected to the Institute of Medicine of the National Academies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn Medicine team reports on study of first 59 leukemia patients who received cell therapy
(Date:3/23/2015)... --  HOYOS Labs , a leading global authentication infrastructure ... Company will demonstrate multiple biometrics-based technologies under its identity ... on March 23 through 25, 2015, in ... IEEE Biometric Open Protocol Standard; free biometrics-based consumer app, ... system. BOPS was invented by HOYOS Labs and contributed ...
(Date:3/20/2015)... Mar. 20, 2015 Research and Markets ... of the "India Sensors Market Forecast and ... The sensor market is projected to grow ... Consumer electronics, automotive, industrial and healthcare sectors ... the country. In addition, adoption of MEMS technology ...
(Date:3/20/2015)... Markets ( http://www.researchandmarkets.com/research/vkzvcs/iris_biometrics ) has announced the addition ... report to their offering. This report analyzes ... report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... . Annual estimates and forecasts are provided for ...
Breaking Biology News(10 mins):HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5
... head-to-head comparison of "improved cookstoves" (ICs) and traditional mud ... emit more of the worrisome "black carbon," or soot, ... concerns than traditional mud stoves or open-cook fires. The ... a clean cooking technology in the developing world, appears ...
... 2012 A new lecture series at the University of Houston ... making a difference in health and medicine. The first of five ... 25 at the Hilton University of Houston. The theme ... and will focus on diabetes, obesity, heart disease and cancer. Sponsored ...
... Mass. The U.S. National Research Council this week ... in 60 countries who took part in the International ... years to offer a benchmark for environmental conditions and ... of Massachusetts Amherst geosciences researcher and expert in the ...
Cached Biology News:New UH lecture series examines impact of science on health 2NRC authors brief federal agencies on the state of polar regions 2NRC authors brief federal agencies on the state of polar regions 3
(Date:4/17/2015)... Fremont, CA (PRWEB) April 17, 2015 ... http://www.medispend.com ) for its 20 Most Promising Pharma and ... based on MMIS’s MediSpend global compliance software platform for ... companies is selected by a panel of experts and ... promote technology entrepreneurship. “MMIS’s MediSpend Platform has been on ...
(Date:4/17/2015)... April 17, 2015 Global Stem ... GTCbio Stem Cell Summit 2015 April 27 - 29, ... latest developments in all areas of stem cell research ... stem cells and regenerative medicine. , The conference ... as well as translational research in stem cell therapies, ...
(Date:4/16/2015)... OSAKA, Japan , April 16, ... (CiRA) of Kyoto University and Takeda Pharmaceutical Company ... together to develop clinical applications of induced pluripotent ... diabetes mellitus, neurological disorders and cancer immunotherapy. The ... is designed to expedite multiple research projects for ...
(Date:4/16/2015)... April 16, 2015 Proove Biosciences ... Buzz of BIO Contest for the 2015 BIO ... the 2015 BIO International Convention will take place June ... During the Buzz of BIO contest, industry leaders will ... present at the conference. The community voting period began ...
Breaking Biology Technology:MMIS Chosen by CIO Review as Top 20 Most Promising Pharma and Life Science Technology Solution Providers 2015 2Global Stem Cells Group To Join GTCbio Stem Cell and Regenerative Medicine Summit in Boston, April 27-29, 2015 2Global Stem Cells Group To Join GTCbio Stem Cell and Regenerative Medicine Summit in Boston, April 27-29, 2015 3CiRA and Takeda Enter 10-year Collaboration on iPS Cell Research 2CiRA and Takeda Enter 10-year Collaboration on iPS Cell Research 3Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 2Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 3
... 11, 2011 Ardea Biosciences, Inc. (Nasdaq: ... of small-molecule therapeutics for the treatment of serious diseases, ... full-year 2010 financial results. "With approximately $160 ... we are in an excellent financial position," commented Barry ...
... 11, 2011 BioSpecifics Technologies Corp. (Nasdaq: BSTC ... collagenase-based products, today announced its financial results for the fourth ... "2010 was an exciting year for the Company, but ... forward to sales growth of XIAFLEX® in the U.S., as ...
... How fast an intense laser pulse can change the ... Kiel University in the current edition of Nature ... Bauer, Dr. Kai Ronagel and Professor Lutz Kipp from ... colleagues from the University of Kaiserslautern and the University ...
Cached Biology Technology:Ardea Biosciences Reports Recent Accomplishments and Announces Fourth Quarter and Full-Year 2010 Financial Results 2Ardea Biosciences Reports Recent Accomplishments and Announces Fourth Quarter and Full-Year 2010 Financial Results 3Ardea Biosciences Reports Recent Accomplishments and Announces Fourth Quarter and Full-Year 2010 Financial Results 4Ardea Biosciences Reports Recent Accomplishments and Announces Fourth Quarter and Full-Year 2010 Financial Results 5Ardea Biosciences Reports Recent Accomplishments and Announces Fourth Quarter and Full-Year 2010 Financial Results 6BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2010 Financial Results 2BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2010 Financial Results 3BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2010 Financial Results 4BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2010 Financial Results 5BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2010 Financial Results 6BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2010 Financial Results 7
Sf21 Insect Cells (Live) in Max-XP Medium...
... The BioGenex Super ... System is a novel ... proprietary non-biotin polymeric technology. ... high signal to noise ...
Artisan™ Wash Solution (x 50) Additional Information: EU regulatory status: CE US regulatory status: IVD ...
MiniCycler thermal cycler with Hot Bonnet heated lid, holds 25x0.2ml tubes...
Biology Products: