Navigation Links
Penn Medicine researcher receives $6 million grant for cardiovascular disease study
Date:1/3/2011

(PHILADELPHIA) An international team of researchers led by Daniel J. Rader, MD, associate director of Penn Medicine's Institute for Translational Medicine and Therapeutics, has received a $6 million grant from the Paris-based Fondation Leducq to study the molecular genetics of atherosclerotic cardiovascular disease. The team's proposal, "Molecular Mechanisms of Novel Genes Associated with Plasma Lipids and Cardiovascular Disease," was selected to receive the award through the Fondation's Transatlantic Networks of Excellence Program.

The investigation will focus on determining the molecular mechanisms of some of the most compelling genes to come out of genome-wide association studies (GWAS) for coronary heart disease and heart attack. Specifically, the research team will study six novel genes found by GWAS to be associated with heart disease in order to rigorously assess their function in physiological processes associated with cardiovascular disease and whether or not they are viable targets for future therapeutic developments.

The multidisciplinary, international research team includes experts in epidemiology, human genetics, molecular and cell biology, and animal physiology. In addition to identifying new potential therapeutic targets, this research program will also establish an infrastructure for the systematic evaluation of future GWAS results in the area of cardiovascular disease.

The award is funded through the Fondation Leducq's Transatlantic Networks of Excellence Program. Each research network receives $6 million over five years to support a collaborative research program involving European and North American investigators.

In addition to Rader, other scientists involved in the study include:

European Coordinator: Christian Weber, MD, RWTH, Aachen University, Germany

Members: Endre Kiss-Toth, PhD, University of Sheffield, United Kingdom; Thomas Quertermous, MD, Stanford Cardiovascular Medicine, US; Sekar Kathiresan, MD, Harvard Medical School and Massachusetts General Hospital, US; Mason Freeman, MD, Massachusetts General Hospital, US; Heiko Runz, MD, University of Heidelberg, Germany; Rainer Pepperkok, PhD, European Molecular Biology Laboratory, Germany; John Danesh, PhD, University of Cambridge, United Kingdom; Robert Hegele, MD, University of Western Ontario, Canada; Ronald Krauss, MD, University of California, Berkeley, US; Marju Orho-Melander, MD, Lund University, Sweden; and Ira Tabas, MD, PhD, Columbia University, US.

The Fondation Leducq, a Paris-based nonprofit institution, is dedicated to improving human health through international efforts to combat cardiovascular disease.


'/>"/>

Contact: Jessica Mikulski
jessica.mikulski@uphs.upenn.edu
215-349-8369
University of Pennsylvania School of Medicine
Source:Eurekalert

Related biology news :

1. New way to make malaria medicine also first step in finding new antibiotics
2. Where optics meets medicine
3. Salk researcher Terry Sejnowski elected to Institute of Medicine
4. Innovations in Pediatric Medicine CME conference brings together national pediatrics experts
5. Rutgers scholar authors definitive biography of reproductive medicine pioneer
6. Growing fuel and medicine: Advancing biofuels and plant-produced therapeutics
7. Researchers at UH explore patient preferences for personalized medicine
8. Innovations in Pediatric Medicine International Conference brings together pediatrics experts
9. Personalized medicine: Innovative online journal leads the way
10. The next step in health care: Telemedicine
11. Nature Medicine study shows Peregrines bavituximab can cure lethal virus infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... 24, 2017 The Controller General of Immigration from ... Abdulla Algeen have received the prestigious international IAIR Award for the ... Continue Reading ... ... Controller Abdulla Algeen (small picture on the right) have received the IAIR ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
(Date:10/10/2017)... 10, 2017 International research firm Parks Associates announced ... at the TMA 2017 Annual Meeting , October 11 in ... residential home security market and how smart safety and security products impact ... Parks Associates: Smart Home ... "The residential security market has ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology: