Navigation Links
Pavlov's rats? Rodents trained to link rewards to visual cues
Date:1/24/2013

p>Knowing that the basal forebrain is implicated in learning, the researchers wanted to know if their observations could be explained by nerves from the basal forebrain delivering ACh to the vision-processing center. To remove those nerve cells from the equation, they paired a neurotoxin with a "homing device" that targets only ACh-releasing neurons coming from the basal forebrain. They then repeated their experiments in trained rats that received the neurotoxin and in those that didn't, and found that the nerve cell signals continued to relay the old time intervals, suggesting that ACh and the basal forebrain weren't needed to express previously learned time information.

The researchers next used those same rats to ask if ACh is necessary for nerve cells to learn new time delays. To do that, they switched the visual cues so that a flash in the left eye meant a long delay and one in the right eye meant a short one. Vision-processing nerve cells in the rats in which ACh delivery was left intact adapted their signals to the new associations; but those in the rats that no longer received ACh continued to relay the old associations, suggesting that ACh is necessary to make new associations but not to express old ones.

Hussain Shuler explains, "When a reward is received, ACh is sent throughout the brain and reinforces only those nerve cell connections that were recently active. The process of conditioning continues to strengthen these nerve connections, giving rise to a timed expectation of reward in the brain."

According to Hussain Shuler, studies have shown that Alzheimer's patients have low levels of ACh and have trouble forming new memories. Though medication may elevate ACh, alleviation of symptoms is limited. "Our research explains that limitation," he says. "Therapeutically, we predict that the problem isn't just low levels of ACh the timing of ACh delivery is key."

Other authors of the report include Emma Roach of the Johns
'/>"/>

Contact: Vanessa McMains
vmcmain1@jhmi.edu
410-502-9410
Johns Hopkins Medicine
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. RATS research may teach rodents to detect explosives
2. New species of ancient rodents hint at what could be worlds oldest grasslands
3. Thieving rodents: Did they save tropical trees?
4. Have thieving rodents saved tropical trees?
5. A trained palate: Understanding complexities of taste, smell could lead to improved diet
6. Risks and rewards of quantifying natures ecosystem services
7. Primates brains make visual maps using triangular grids
8. Military vision research symposium focuses on visual fallout from war
9. Stealthy microscopy method visualizes E. coli sub-cellular structure in 3-D
10. 2 NASA visualizations selected for computers graphics showcase
11. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Pavlov's rats? Rodents trained to link rewards to visual cues
(Date:4/27/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... growing mobile commerce market, announces that its Wocket® Smart ... week of May, 2015 and will be fulfilling all ... Gino Pereira , Chief Executive Officer said, ... Wocket® enters the consumer market. We would like to ...
(Date:4/21/2015)... Canada , April 21, 2015 ... and evolving government policies are boosting access control systems ... According to a recently published report by ... Opportunities, 2020 ", the access control systems market in ... nearly USD1.2 billion by 2020.The access control systems market ...
(Date:4/20/2015)... The announcement comes as demand ... Management (GRM), Ireland,s foremost records management ... built up an impressive track record of clients within the ... the records management sector in Dubai . ... staffbase and employ a further eight staff members at its ...
Breaking Biology News(10 mins):Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3
... scientist from the University of Salamanca and another from Yale ... behaviour of Acanthodactylus beershebensis , a lizard species from ... study, these reptiles move less and catch less mobile and ... Many theoretical models had predicted this result, but until now ...
... OptiNose is pleased to announce the publication of results ... and tolerability of its novel, intranasal drug/device product for ... in Rhinology , the official journal of the ... with nasal polyps is a chronic disease that can ...
... been awarded a U.S. Air Force Center of Excellence ... and to develop tools to optimize critical cognitive processes ... Center, known as the Bio-nano-enabled Inorganic/Organic Nanostructures and Improved ... and Kenneth Sandhage, professors in Georgia Tech,s School of ...
Cached Biology News:Lizards change their diet to avoid predators 2New data on highly effective treatment for chronic rhinosinusitis with nasal polyps 2Air Force Center of Excellence awarded in nanostructures and improved cognition 2Air Force Center of Excellence awarded in nanostructures and improved cognition 3Air Force Center of Excellence awarded in nanostructures and improved cognition 4
(Date:5/27/2015)... OAKLAND, Calif. , May 27, 2015  Two ... tinkerers, biotech professionals, hackers and citizen scientists, ... a $30,000 crowdfunding campaign promoting its mission to democratize ... city,s Temescal District. ... Based out ...
(Date:5/27/2015)... 27, 2015  US-Australian drug discovery and development company, Novogen ... it will present at the Brain Tumor Biotech Summit 2015, ... May 29, 2015. The venue is the Lennox Hill Hospital, ... The Brain Tumor Biotech Summit brings together ... and the investment community to promote innovative new therapies for ...
(Date:5/27/2015)... Madison, NJ (PRWEB) May 27, 2015 ... for evaluating the impact of regulation on medical innovation, ... Centered Innovation (iPCI) of Fairleigh Dickinson University’s ( ... inaugural MI3 Alert pertains to new FDA ... Senate proposal for accelerating the approval of certain medical ...
(Date:5/26/2015)... Canada, and BELLINGHAM, Washington, USA (PRWEB) May 26, 2015 ... has signed a formal partnership with the Max ... Centre for Extreme and Quantum Photonics. The center will ... the field of photonics, and will be only the ... CEO of SPIE, the international society for optics ...
Breaking Biology Technology:East Bay's Counter Culture Labs Seeks to Open Doors of Science to Public 2East Bay's Counter Culture Labs Seeks to Open Doors of Science to Public 3Novogen to Present at Brain Tumor Biotech Summit 2015 2Novogen to Present at Brain Tumor Biotech Summit 2015 3Novogen to Present at Brain Tumor Biotech Summit 2015 4Novogen to Present at Brain Tumor Biotech Summit 2015 5Medical Innovation Impact Index Launched at Fairleigh Dickinson University’s Initiative for Patient-Centered Innovation (iPCI) under the Rothman Institute 2Third Max Planck Centre in North America Inaugurated at University of Ottawa 2Third Max Planck Centre in North America Inaugurated at University of Ottawa 3
... , , , , , , , , ... Biotech Ltd. ( SVA),a leading provider of biopharmaceutical products in ... presented with the Annual,Innovation Award by China Central Television (CCTV). ... nominees for the CCTV,s China,s 2009 Economic,Man-of-the-Year. Results were ...
... River green on St. Patrick,s Day. It,s been used to ... at Northwestern University have used it to examine the thinnest ... dye fluorescein, and Jiaxing Huang, assistant professor of materials science ... Science, and his research group have used the dye to ...
... ... clinical consulting services, competitive intelligence and strategic planning for the medical device and biotechnology ... company in the development, promotion and implementation of The RC Insight Group. , ... (PRWEB) December 23, 2009 ...
Cached Biology Technology:Sinovac's CEO Weidong Yin Presented with Annual Innovation Award by China Central Television 2Sinovac's CEO Weidong Yin Presented with Annual Innovation Award by China Central Television 3An easy way to see the world's thinnest material 2Lori Kahler Appointed President of The RC Insight Group 2
AADAC Immunogen: AADAC (NP_001077, 201 a.a. ~ 301 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
WTAP Antibody...
Phospho-TAK1 (Thr184/187) (90C7) Rabbit mAb Shipping Temperature: Cold Storage Temperature: -20C...
Rat monoclonal to UGGT ( Abpromise for all tested applications)....
Biology Products: