Navigation Links
Patterns of new DNA letter in brain suggest distinct function
Date:10/30/2011

are turned off or on repetitive "junk" regions of the genome. When stem cells change into the cells that make up blood, muscle or brain, 5-mC helps shut off genes that aren't supposed to be turned on. Changes in 5-mC's distribution also underpin a healthy cell's transformation into a cancer cell.

It looks like 5-hmC can only appear on DNA where 5-mC already was present. This could be a clue that 5-hmC could be a transitory sign that the cell is going to remove a 5-mC mark. Jin says the patterns his team sees tell a different story, at least for some genes. On those genes, the level of 5-hmC is stably maintained and increases with age.

The Emory team used a method for chemically labeling 5-hmC they developed in cooperation with scientists at the University of Chicago. They find that 5-hmC is ten times more abundant in brain than in stem cells, and it is found more in the body of some genes, compared to stem cells.

In addition, the researchers found a relative lack of 5-hmC on X chromosomes in both males and females. That result is a surprise, Jin says, because it was already known that the X chromosome is subject to a special form of regulation in females only. Males have one X chromosome and females have two, and in female cells one of the X chromosomes is inactivated.

Jin's team is beginning to map how 5-hmC changes in neurological disorders, including Rett syndrome and autism, and refining techniques for detecting 5-hmC in DNA at high resolution.


'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists Find new migratory patterns for Mediterranean and Western Atlantic bluefin tuna
2. Researchers examine role of soil patterns in dam restoration
3. DNA repair patterns may predict risk of pancreatic cancer
4. UK researcher identifies just 8 patterns as the cause of all humor
5. NOAA researchers: Blue whales re-establishing former migration patterns
6. Researchers gain genome-wide insights into patterns of the worlds human population structures
7. Geographic profiling applied to track hunting patterns of white sharks in South Africa
8. Are holiday and weekend eating patterns affecting obesity rates?
9. Genetic patterns rise from huge yeast samples
10. Visualization of geographic patterns may predict spread of disease
11. Patterns of growth changing in Inuit preschoolers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... IN August 1, 2014 The Journal of ... Article and Best Great Educational Material (GEM) awards, which ... Behavior (SNEB) annual conference, "Nutrition Education Impact: Local to ... 2014. These annual awards recognize the authors of ... in JNEB, as judged by members of the JNEB ...
(Date:8/1/2014)... , Aug. 1, 2014  LiveScan Service Provider Binary Biometrics ... team. As a result, Binary Biometrics will improve its mobile service capabilities and ... Volusia County and service several new cities such as, but ... , DeLand , Deltona , ... , New Smyrna Beach , Oak Hill ...
(Date:7/31/2014)... study of bigeye tuna movements in the northwestern Atlantic ... Pelagics Research Center at the University of Massachusetts Amherst, ... wide geographical range with pronounced north-south movements from Georges ... high-use area off Cape Hatteras southwest of Bermuda for ... approach to study one of the most important commercial ...
Breaking Biology News(10 mins):Binary Biometrics, Founded by James Timothy White, Expands Services to 13+ Locations With the Addition of Owner/Operator Kevin Morris 2Binary Biometrics, Founded by James Timothy White, Expands Services to 13+ Locations With the Addition of Owner/Operator Kevin Morris 3Study of bigeye tuna in Northwest Atlantic uses new tracking methods 2Study of bigeye tuna in Northwest Atlantic uses new tracking methods 3
... Studies has received a $42 million gift-the largest in ... Medicine (HCGM), a research center dedicated to decoding the ... The award, from the Leona M. and Harry ... paves the way to new therapies for chronic illnesses ...
... DIEGO , Jan. 23, 2013 Celladon ... and development of innovative treatments for cardiovascular diseases, ... Trademark Office (USPTO) issued a notice of allowance ... that cover methods for identifying compounds that modulate ...
... water bottles, food containers, and baby products had a ... used to make their merchandise, an organic compound called ... asthma and cancer and altered prostate and neurological development. ... restrict BPA,s use, and the public was pressuring retailers ...
Cached Biology News:Salk Institute awarded historic $42 million grant from the Helmsley Charitable Trust 2Salk Institute awarded historic $42 million grant from the Helmsley Charitable Trust 3Celladon Corporation Receives Notice of Allowance from United States Patent and Trademark Office 2Celladon Corporation Receives Notice of Allowance from United States Patent and Trademark Office 3BPA substitute could spell trouble 2
(Date:7/31/2014)... July 31, 2014 Nearly 20,000 medical professionals ... Annual Meeting & Clinical Lab Expo in ... never-before-seen breakthroughs in diagnostic research and technology that will ... As of Wednesday, July 30, more than ... Meeting & Clinical Lab Expo, with more than 10,000 ...
(Date:7/31/2014)... Hopkins have mapped the sound-processing part of the mouse ... forest and the trees in view. Their imaging technique ... activity within mice, and it enabled the team to ... each other. The results, which represent a step toward ... online July 31 the journal Neuron . , ...
(Date:7/31/2014)... Rogne Bioscience, a privately-held biotechnology company based ... has acquired a licence to anti-inflammatory peptides from Isis ... anti-inflammatory activity of the peptides was discovered by Professor ... Sir William Dunn School of Pathology. ... million in seed financing, is developing a first-in-class, topical ...
(Date:7/31/2014)... July 31, 2014 Research and Markets ... Genomics Market 2014-2018" report to their offering. ... is the study of the genetic material or genomes ... strong basis for the discovery and development of diagnostic ... or health conditions. Genomics is supported by three major ...
Breaking Biology Technology:Research on Digital Health, Alzheimer's, Ebola Draws Nearly 20,000 Attendees to 2014 AACC Annual Meeting & Clinical Lab Expo 2Research on Digital Health, Alzheimer's, Ebola Draws Nearly 20,000 Attendees to 2014 AACC Annual Meeting & Clinical Lab Expo 3New mapping approach lets scientists zoom in and out as the brain processes sound 2Oxford licenses anti-inflammatory peptides to San Francisco Bay Area start-up 2Oxford licenses anti-inflammatory peptides to San Francisco Bay Area start-up 3Global Genomics Market 2014-2018: Key Vendors are F. Hoffmann-La Roche, Life Technologies, Qiagen and Illumina 2
... Women with Endometriosis -, PHOENIX and BRITISH ... and Medical Center, part of Catholic Healthcare,West, one ... with 42 hospitals,in Arizona, California and Nevada and ... IXS; http://www.ixsbio.com ), a drug,development company commercializing ...
... NORRITON, Pa., Sept. 19 Tengion Inc., a ... of,neo-organs and neo-tissues, today announced that it was ... venture capital-backed innovation and,success at the 35th Anniversary ... Sherrill Neff, Partner at Quaker BioVentures -- a,venture ...
... HARBIN, China, Sept. 19 /Xinhua-PRNewswire-FirstCall/ -- China Sky ... Company") (Nasdaq: CSKI ), a,leading fully integrated ... of China ("PRC"), announced today that it,has successfully ... Europeenne (CE) certification, or CE mark, which indicates ...
Cached Biology Technology:St. Joseph's Hospital and InNexus Biotechnology Enter Collaborative Partnership 2St. Joseph's Hospital and InNexus Biotechnology Enter Collaborative Partnership 3Tengion Featured as Model of Innovation and Success at 35th Anniversary Celebration of the National Venture Capital Association 2China Sky One Medical, Inc. Passes First Phase Examination for (CE) Certification 2China Sky One Medical, Inc. Passes First Phase Examination for (CE) Certification 3
... XL provides balance data collection and automation that ... integration with Microsoft Excel , Pre-configured library ... , New balances can be added and configured ... from multiple balances into one spreadsheet ...
Applications: Western blotting ...
...
Mitochondria/Cytosol Fractionation Kit Research Focus: other Storage Temperature: 4C Shipping Temperature: 4C...
Biology Products: