Navigation Links
Patterns of new DNA letter in brain suggest distinct function
Date:10/30/2011

are turned off or on repetitive "junk" regions of the genome. When stem cells change into the cells that make up blood, muscle or brain, 5-mC helps shut off genes that aren't supposed to be turned on. Changes in 5-mC's distribution also underpin a healthy cell's transformation into a cancer cell.

It looks like 5-hmC can only appear on DNA where 5-mC already was present. This could be a clue that 5-hmC could be a transitory sign that the cell is going to remove a 5-mC mark. Jin says the patterns his team sees tell a different story, at least for some genes. On those genes, the level of 5-hmC is stably maintained and increases with age.

The Emory team used a method for chemically labeling 5-hmC they developed in cooperation with scientists at the University of Chicago. They find that 5-hmC is ten times more abundant in brain than in stem cells, and it is found more in the body of some genes, compared to stem cells.

In addition, the researchers found a relative lack of 5-hmC on X chromosomes in both males and females. That result is a surprise, Jin says, because it was already known that the X chromosome is subject to a special form of regulation in females only. Males have one X chromosome and females have two, and in female cells one of the X chromosomes is inactivated.

Jin's team is beginning to map how 5-hmC changes in neurological disorders, including Rett syndrome and autism, and refining techniques for detecting 5-hmC in DNA at high resolution.


'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists Find new migratory patterns for Mediterranean and Western Atlantic bluefin tuna
2. Researchers examine role of soil patterns in dam restoration
3. DNA repair patterns may predict risk of pancreatic cancer
4. UK researcher identifies just 8 patterns as the cause of all humor
5. NOAA researchers: Blue whales re-establishing former migration patterns
6. Researchers gain genome-wide insights into patterns of the worlds human population structures
7. Geographic profiling applied to track hunting patterns of white sharks in South Africa
8. Are holiday and weekend eating patterns affecting obesity rates?
9. Genetic patterns rise from huge yeast samples
10. Visualization of geographic patterns may predict spread of disease
11. Patterns of growth changing in Inuit preschoolers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... animalsto thrive in the oceans, there must be ... coastal areas, extreme oxygen-starvation produces "dead zones" that ... As dissolved oxygen levels decline, energy is increasingly ... metabolism resulting in impacts on the ecology and ... 50 years, oxygen minimum zones (OMZs) have expanded ...
(Date:9/15/2014)... scientists from GEOMAR Helmholtz Centre for Ocean Research ... have demonstrated for the first time, that the ... oceans, Emiliania huxleyi , can adapt simultaneously ... their study, the researchers found no evidence for ... two aspects of climate change would interfere with ...
(Date:9/15/2014)... 100 feet long and weighing as much as 170 tons, ... and by far the heaviest living thing ever seen on ... common with the tiniest fish larvae, which measure millimeters in ... gram, right? , Not so fast, says L. Mahadevan, ... Organismic and Evolutionary Biology, and of Physics. , Using ...
Breaking Biology News(10 mins):Decoding virus-host interactions in the oxygen-starved ocean 2Decoding virus-host interactions in the oxygen-starved ocean 3Decoding virus-host interactions in the oxygen-starved ocean 4Decoding virus-host interactions in the oxygen-starved ocean 5Small algae with great potential 2Small algae with great potential 3The science behind swimming 2The science behind swimming 3
... often simply called lupus, is a complex autoimmune ... fatigue, and depression, among other symptoms. Some studies ... severe psychiatric manifestation, psychosis, and a protein autoantibody ... , To investigate how an autoantibody ...
... continue to debate how different species manage to ... as food, invariably one will be more efficient ... that each species has evolved morphological or physiological ... more efficiently than all other species. Such partitioning ...
... Genetics tests could help provide cystic fibrosis (CF) ... authors suggest. Results from a French clinical trial ... small percentage of CF sufferers with a rare ... , Aleksander Edelman and Isabelle Sermet-Gaudelus of Faculté ...
Cached Biology News:New insights into autoimmunity and depression 2Virtual duck bills demonstrate species coexistence 2
(Date:9/12/2014)... Arthur Kay , the 23-year-old British founder of environmentally ... Challenge 2014. The jury, chaired by Ellen MacArthur ... final in Amsterdam to realize ... uses a patented process to upcycle waste coffee grounds ... used for powering buildings and transport systems. Bio-bean is ...
(Date:9/12/2014)... September 12, 2014 Today, “The University” ... Indiegogo. , The film, directed by former Charlie ... Shimon Peres, Ashton Kutcher, Will.i.Am, Michio Kaku, and others. ... there’s only one university in the world devoted to ... the lives of a billion people: Singularity University. Matt ...
(Date:9/11/2014)... 12, 2014 RURO, Inc., a ... (RFID) solutions and sample management solutions provider, announces ... completed work on the most recent version of ... has already seen mass adoption, especially from multi-license ... version 5.0 brought an entirely new User Interface ...
(Date:9/11/2014)... to show the use of sound to communicate with ... quantum physics with sound taking on the role of ... Science . , The interaction between atoms and ... in the field of quantum optics. However, to achieve ... been a more challenging undertaking. The Chalmers researchers have ...
Breaking Biology Technology:Green Startup Bio-Bean Wins $680,000 in Postcode Lottery Green Challenge 2Green Startup Bio-Bean Wins $680,000 in Postcode Lottery Green Challenge 3Documentary Film that Follows Singularity University Students as They Change the World Launches its IndieGoGo Fundraising Campaign 2Limfinity® Version 5.1 Available 2The sound of an atom has been captured 2
... High Quality Digital Imaging Solution Now Available in ... Medical Systems, a leading supplier of digital radiography ... and practice management software (VIA(R)), will showcase its ... RapidStudy(TM) DR imaging solutions at the annual Central ...
... April 22 GeneGo, Inc., a leading provider of ... analysis , today announced that the University of Cardiff ... University researchers will have access to GeneGo,s MetaCore, training ... leverage their partner relationship with GeneGo to provide a ...
... The PharmSource ADVANTAGE online service has added two new capabilities ... providers. , ... Fairfax, Virginia (PRWEB) ... provider of business intelligence on contract drug development and manufacture, ...
Cached Biology Technology:Eklin Medical Systems to Showcase RapidStudy(TM) CDx Digital Radiography Systems at CVC East 2Eklin Medical Systems to Showcase RapidStudy(TM) CDx Digital Radiography Systems at CVC East 3Cardiff University Becomes a GeneGo Center of Excellence 2PharmSource Adds New Capabilities to the PharmSource ADVANTAGE Online Service 2
... that enables fully automated hybridization of microarrays ... has been designed to offer researchers improved ... to perform a wide range of applications. ... range 485C; denaturations of up to 99C. ...
... cDNA Synthesis and Labeling Kit generates labeled ... First unmodified cDNA is made via a ... an Oligo(dT) primer. Unlike other methods, there ... the reverse transcription reaction. This unmodified cDNA ...
... Kits overcome this limitation and offer high ... range in low-density protein array (96- and ... ideal for performing reverse-phase protein arrays and ... presence of low abundant antigens. Protein Detector ...
AC input: 50-60 Hz230 V...
Biology Products: