Navigation Links
Patients' own skin cells are transformed into heart cells to create 'disease in a dish'
Date:1/27/2013

one of the largest ARVD/C patient registries in the world.

"There is currently no treatment to prevent progression of ARVD/C, a rare disorder that preferentially affects athletes. With this new model, we hope we are now on a path to develop better therapies for this life-threatening disease," said Judge, associate professor and medical director of the Center for Inherited Heart Disease at the Johns Hopkins University School of Medicine.

Disease in a dish

To recreate a person's own unique ARVD/C in the lab, the team first obtained skin samples from ARVD/C patients with certain mutations believed to be involved in the disease. Next they performed Yamanaka's technique: adding a few molecules that dial back the developmental clock on these adult skin cells, producing embryonic-like induced pluripotent stem cells (iPSCs). The researchers then coaxed the iPSCs into producing an unlimited supply of patient-specific heart muscle cells. These heart cells were largely embryonic in nature, but carried along the original patient's genetic mutations.

However, for nearly a year, no matter what they tried, the team couldn't get their ARVD/C heart muscle cells to show any signs of the disease. Without actual signs of adult-onset ARVD/C, these young, patient-specific heart muscle cells were no use for studying the disease or testing new therapeutic drugs.

Speeding up time

Eventually, the team experienced the big "aha!" moment they'd been looking for. They discovered that metabolic maturity is the key to inducing signs of ARVD/C, an adult disease, in their embryonic-like cells. Human fetal heart muscle cells use glucose (sugar) as their primary source of energy. In contrast, adult heart muscle cells prefer using fat for energy production. So Chen's team applied several cocktails to trigger this shift to adult metabolism in their model.

After more trial and error, they discovered that metabolic malfuncti
'/>"/>

Contact: Heather Buschman
hbuschman@sanfordburnham.org
858-795-5343
Sanford-Burnham Medical Research Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Planning for bacteria in cancer patients may help hospitals fight infections
2. New research may aid treatment of multiple myeloma patients
3. Scientists discover needle in a haystack for muscular dystrophy patients
4. Promising new finding for therapies to treat persistent seizures in epileptic patients
5. Patients with EGFR exon 20 insertions have poorer prognosis
6. Intensive training for aphasia: Even older patients can improve
7. Snack attack: Eating unhealthy snack foods may affect cancer risk in patients with Lynch syndrome
8. Vaccine offers promise as post-surgery treatment for pancreatic cancer patients
9. Leukemia patients remain in remission more than 2 years after engineered T cell therapy
10. Another muscular dystrophy mystery solved; MU scientists inch closer to a therapy for patients
11. TGen-US Oncology data guides treatment of metastatic triple-negative breast cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Patients' own skin cells are transformed into heart cells  to create 'disease in a dish'
(Date:8/22/2014)... first comprehensive study of captive black rhino reproduction ... the success of breeding programmes. , Researchers from ... University of Liverpool carried out a six-year study ... rhino. , Dr Katie Edwards led the research ... of Liverpool. She says: "Although some black rhinoceros ...
(Date:8/22/2014)... 2015, American consumers will finally be able to purchase ... touted as zero-emissions vehicles, most of the cars will ... fuel that contributes to global warming. , Now scientists ... that uses an ordinary AAA battery to produce hydrogen ... current through two electrodes that split liquid water into ...
(Date:8/21/2014)... toxins in past decade, GTA still violates Canada,s ... while the Greater Toronto Area (GTA) has significantly ... smog, the city continues to violate the Canada-wide ... cause or aggravate health problems such as asthma, ... set of complex photochemical reactions involving volatile organic ...
Breaking Biology News(10 mins):Hormone analysis helps identify horny rhinos 2Stanford scientists develop a water splitter that runs on an ordinary AAA battery 2Stanford scientists develop a water splitter that runs on an ordinary AAA battery 3Despite a significant reduction in smog-producing toxins, the Greater Toronto Area still violates Canada's standards for ozone air pollution 2
... Fourth Biennial Review, 2012 -- a new congressionally mandated ... in the Comprehensive Everglades Restoration Plan (CERP), a multibillion-dollar, ... the ecosystem,s decline while meeting growing demands for clean ... evaluation of CERP, which was launched in 2000 by ...
... in cellular DNA can trigger tumorigenesis. Researchers from ... structure of a protein involved in the repair ... throws new light on the origins of neurodegenerative ... as radiation or environmental toxins can cause double-stranded ...
... Digicel Pacific Limited, a mobile network operator across the Pacific ... deploying biometric enabled payment systems into stores in New Zealand ... way to send money home to the Pacific. ... register just once and record their fingerprint as permanent identification ...
Cached Biology News:Digicel Launches World's First Biometric Identification System For International Money Transfers 2Digicel Launches World's First Biometric Identification System For International Money Transfers 3
(Date:8/21/2014)... August 21, 2014 On Wednesday of last ... to use Redox Signaling molecules, became available for purchase in ... , "The way that RENU 28 works is, if you ... down of the rate of cellular renewal within your body. ... increasing of that rate of cellular renewal. What RENU 28 ...
(Date:8/20/2014)... history lessons often have it that American Indians largely ... chicken pox, influenza and tuberculosis brought to the New ... vary, about 20 million people lived in the Americas ... them were killed by European diseases., But new research ... University and Johannes Krause of the University of Tubingen ...
(Date:8/20/2014)... California (PRWEB) August 20, 2014 ... develop and apply the most complete climate and ... and demanding climate change issues. , Eight national ... forces with the National Center for Atmospheric Research, ... the new effort. Other participating national laboratories include ...
(Date:8/20/2014)... 2014 The 6th Annual Arrowhead ... on October 29-30 in San Francisco, CA. This year’s ... government researchers and clinicians focused on addressing and solving ... In the twelve years since the sequencing of the ... introduced with pharmacogenetic information in the label and molecular ...
Breaking Biology Technology:RENU 28 Skin Care Now Available in Australia and New Zealand 2Unusual discovery leads to fascinating tuberculosis theory 2Unusual discovery leads to fascinating tuberculosis theory 3New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 36th Annual Personalized and Precision Medicine Conference Bringing Together Thought Leaders to Discuss Clinical Implementation, Dx Reimbursement, Big Data, and Sequencing 2
... COLOGNE, Germany and ... has opened its seventh laboratory worldwide in Electronics City in,the ... and systems. The world,leader in independent safety and quality testing ... new solar test centre, which in particular will,offer services to ...
... team based at the University of Pittsburgh has received ... of Defense to tackle some of the most significant ... that could solve problems too complex for all of ... the Universe to crack. The project was one of ...
... AVANIR Pharmaceuticals, Inc. (Nasdaq: ... Annual Canaccord Genuity Growth Conference on Tuesday, August 10th at ... at the InterContinental Hotel in Boston .  The Canaccord Genuity Growth ... and industry leaders.   , , ...
Cached Biology Technology:New Test Centre in India: TUV Rheinland Continues Worldwide Investment Programme for Solar Industry 2New Test Centre in India: TUV Rheinland Continues Worldwide Investment Programme for Solar Industry 3Pitt-led researchers to build foundation for quantum supercomputers with $7.5 million federal grant 2AVANIR to Present at the Canaccord Genuity Growth Conference 2
Sequencing and primer design rolled into one. Just give us your clone and a reference sequence, and we'll do the rest. Single-strand or double-strand coverage. Guaranteed results....
... polyclonal antibody to human XAB2 (amino terminus) ... identified through its interaction with XPA. Immunoprecipitation ... of XAB2 interacts with the transcription-coupled repair-specific ... with RNA polymerase II. Microinjection experiments with ...
... provide custom microplate coating using advanced automated high throughput microplate ... formats. We can also accommodate virtually any lot size of ... , 8 and 12 ... 384 well microplate, ...
...
Biology Products: