Navigation Links
Pathway for membrane building blocks
Date:1/30/2013

The lipid molecules of membranes, also known as phospholipids, are composed of two elements: A hydrophilic head and two long-chain fatty acids. The molecules form a bilayer in the membrane, with all of the heads pointing outwards and the fatty acid chains hanging in a zip-like interlay position.

Biomembranes are constantly reorganized or renewed, for example whenever cells divide. The cell is constantly creating new phospholipids that have to align themselves which they do in both layers of the biomembrane. However, cells only produce phospholipids on one side of the biomembrane. From there, they need to be transported to the other half of the bilayer.

A helping hand through the membrane

The problem is that the hydrophilic and lipophilic parts of the molecule repel each other. "The molecules can anchor themselves in one of the two membrane layers with their lipophilic tail," explains Prof. Dieter Langosch of the TUM Chair of Biopolymer Chemistry. "Translocation to the second layer is not possible because the hydrophilic heads cannot pass through the lipophilic fatty acid chains."

The key to establishing order in the membranes lies in enzymes that transport the molecules to their correct location in the "second layer". Scientists have been searching for such enzymes known as flippases for many years. But now Prof. Langosch and his team have made a breakthrough. They experimented with synthetic peptides, which transport phospholipids through the membrane.

A clever trick

In this process, the researchers came across an indirect transport mechanism. The peptides span both layers of the membrane and are able to bind to individual phospholipids. Prof. Langosch explains: "When the peptides bind the molecules, the surrounding membrane is briefly destabilized. The new phospholipids use this opportunity to slip through the barrier of the first lipid layer and flip to the second layer of the memb
'/>"/>

Contact: Barbara Wankerl
wankerl@zv.tum.de
49-892-892-2562
Technische Universitaet Muenchen
Source:Eurekalert  

Page: 1 2

Related biology news :

1. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
2. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
3. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
4. Study discovers genetic pathway impacting the spread of cancer cells
5. Researchers pinpoint genetic pathway of rare facial malformation in children
6. A new candidate pathway for treating visceral obesity
7. Study identifies pathway to enhance usefulness of EGFR inhibitors in lung cancer treatment
8. Cleveland Clinic researchers receive $5 million grant to discover novel pathways to heart disease
9. Fragile X and Down syndromes share signalling pathway for intellectual disability
10. New neural pathway controlling skeletal development discovered
11. Discovery of molecular pathway of Alzheimers disease reveals new drug targets
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Pathway for membrane building blocks
(Date:7/9/2014)... Caesarean section have a different intestinal flora than children delivered ... is the case and what it means for the immune ... therefore decided to scrutinise the impact of birth on the ... mouse pups. , The study shows that ... of cells that strengthen the immune system, says Camilla Hartmann ...
(Date:7/9/2014)... switch out one gene for another in a line ... fiction to reality within this decade. As with any ... of fixing disease-causing genes in humans, for example--as well ... put one of those concerns to rest: using gene-editing ... of mutations in the cells. The new results were ...
(Date:7/9/2014)... deer hunts in Indiana state parks have helped restore ... caused by overabundant populations of white-tailed deer, a Purdue ... Jenkins, associate professor of forest ecology, found that a ... hunts in state parks has successfully spurred the regrowth ... by browsing deer. , Jenkins said that while ...
Breaking Biology News(10 mins):Mouse study: Natural birth may strengthen the immune system 2No extra mutations in modified stem cells, study finds 2No extra mutations in modified stem cells, study finds 3Hunting gives deer-damaged forests in state parks a shot at recovery 2
... 12 surgeons and 21 surgical residents, video game skill ... a simulated surgery skills course, according to a report ... of the JAMA/Archives journals. , James C. Rosser Jr., ... colleagues asked 33 surgeons (21 residents and 12 attending ...
... speculated that lead poisoning may have played a role in ... have been caused by the concentration of grape juice in ... damage to the environment, the annual production of lead continues ... glass, and electronic components. However, there has thus far been ...
... made to retain naturally occurring compounds called flavanols may ... and chart the course for future research that could ... dementia, according to a panel of scientists who presented ... Association for the Advancement of Science (AAAS). , Several ...
Cached Biology News:Lead with a poisonous electron shield 2Flavanols in cocoa may offer benefits to the brain 2Flavanols in cocoa may offer benefits to the brain 3
(Date:1/15/2014)... , Jan. 15, 2014  Bill Jacobs Automotive, a group of ... teaming up with the Heartland Blood Center and offering free ... The drive takes place Saturday, Jan. 18 at the Bill ... p.m. (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  The ...
(Date:1/15/2014)... California , January 15, 2014 Oxford ... today announced the appointment of Thomas C Reynolds MD, PhD ... years, development experience gained in the biotechnology industry, most recently ... am delighted to welcome Tom at this transformative time for ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 Two champions ... continued their sponsorship of an annual competition for middle ... and access to, innovative STEM study. The competition presents ... TEAMS: Tests of Engineering Aptitude, Mathematics, and Sciences ...
(Date:1/15/2014)... 2014 AudioNotch is the internet's leading ... the treatment of tinnitus. Patients listen to sound therapy ... a period of weeks to months, their tinnitus volume decreases. ... forms: Notched Music and Notched White Noise. Now, AudioNotch is ...
Breaking Biology Technology:Join the Bill Jacobs Auto blood drive and receive a free oil change 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5
... 2010 Amylin Pharmaceuticals, Inc. (Nasdaq: AMLN ... LLY ) today announced final results from a retrospective ... risk of acute pancreatitis among initiators of BYETTA® (exenatide) ... antidiabetic therapies. These findings were presented at the 70th ...
... N.C. , June 25 Ruedi Waeger , Ph.D., former ... Board of Directors, was honored with the Robert W. Reilly Leadership award ... . , , , ... the Plasma Protein Therapeutics Association (PPTA) and recognizes individuals who exemplify the leadership ...
... , CRANBURY, N.J. , June 25 Palatin ... has entered into definitive agreements with certain accredited investors to sell ... of $0.20 per unit for gross proceeds of ... expenses.  Each unit will consist of one share of common stock ...
Cached Biology Technology:Study Finds BYETTA(R) Use Was Not Associated With Increased Rate of Acute Pancreatitis Compared to Other Antidiabetic Drugs: Final Results Presented at ADA 2010 2Study Finds BYETTA(R) Use Was Not Associated With Increased Rate of Acute Pancreatitis Compared to Other Antidiabetic Drugs: Final Results Presented at ADA 2010 3Study Finds BYETTA(R) Use Was Not Associated With Increased Rate of Acute Pancreatitis Compared to Other Antidiabetic Drugs: Final Results Presented at ADA 2010 4Study Finds BYETTA(R) Use Was Not Associated With Increased Rate of Acute Pancreatitis Compared to Other Antidiabetic Drugs: Final Results Presented at ADA 2010 5Study Finds BYETTA(R) Use Was Not Associated With Increased Rate of Acute Pancreatitis Compared to Other Antidiabetic Drugs: Final Results Presented at ADA 2010 6Study Finds BYETTA(R) Use Was Not Associated With Increased Rate of Acute Pancreatitis Compared to Other Antidiabetic Drugs: Final Results Presented at ADA 2010 7Study Finds BYETTA(R) Use Was Not Associated With Increased Rate of Acute Pancreatitis Compared to Other Antidiabetic Drugs: Final Results Presented at ADA 2010 8Ruedi Waeger Receives the 2010 Robert W. Reilly Leadership Award from Plasma Protein Therapeutics Association 2Palatin Technologies, Inc. to Raise $2.0 Million Dollars in Registered Direct Offering 2Palatin Technologies, Inc. to Raise $2.0 Million Dollars in Registered Direct Offering 3
GlutaMAX-I Supplement...
Chemically Defined Lipid Concentrate...
... Cell Dissociation Buffers are membrane-filtered isotonic ... chelating agents and cell-conditioning agents in ... salt solution or Ca2+- and ... of mammalian cells from support substrates ...
... g Blocking Reagent , 2 x 50 ml 10X ... , 0.2 ml BL21 glycerol stock , 0.2 ... stock , 1010 pfu T7Select Positive Control Lysate , ... l S-protein HRP Conjugate , 2 ml T7Select S-protein ...
Biology Products: