Navigation Links
Pathology study tracks uterine changes with mifepristone
Date:3/7/2011

Research continues to show that the controversial abortion drug mifepristone might have another use, as a therapeutic option besides hysterectomy for women who suffer from severe symptoms associated with uterine fibroids.

The University of Rochester Medical Center in 2004 began investigating mifepristone, in a class of drugs known as progesterone receptor modulators (PRMs), to treat fibroids, which affect roughly half of all women younger than 50. Results showed the drug shrank the fibroids and greatly improved the quality of life for the women involved in the clinical trial.

But concern over whether PRMs could cause tissue changes that signal uterine cancer dampened a growing interest in the drug. The latest URMC study demonstrates that PRMs do not appear to trigger cancerous or pre-cancerous lesions in the lining of the uterus, at least in the short term, according to an article in the journal Human Pathology.

"Our biggest concern was cancer, and although we saw significant changes in the endometrial tissue specific to the action of PRMs, all of the changes were benign and well characterized in the laboratory," said lead investigator Julietta Fiscella, M.D., clinical assistant professor of Pathology and Laboratory Medicine at URMC and Director of Pathology at Highland Hospital, an affiliate of URMC.

Fiscella analyzed 152 tissue samples from 53 premenopausal women in the Rochester, N.Y., area, who volunteered to take mifepristone at very low doses for up to 18 months to alleviate miserable symptoms such as pain and heavy bleeding. She compared samples of unexposed endometrial tissue to samples from women who took the drug in 2.5 mg or 5 mg dosages. (To end an unwanted pregnancy, mifepristone is given in a single-day dose of 200 to 600 mg.)

The changes most evident in the drug-exposed tissue included fluid-filled glands that appeared as scattered, benign cysts of varying size, and some abnormal blood vessel
'/>"/>

Contact: Leslie Orr
Leslie_Orr@urmc.rochester.edu
585-275-5774
University of Rochester Medical Center
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related biology news :

1. Response to immune protein determines pathology of multiple sclerosis
2. Tips from the American Journal of Pathology
3. Tips from the American Journal of Pathology
4. New insight into Alzheimers disease pathology
5. Association for Molecular Pathology joins ACLU to challenge gene patents
6. Tips from the American Journal of Pathology
7. Shaw to receive prestigious honor for plant pathology research
8. Ewen Callaway named 2009 APS Plant Pathology Journalism awardee
9. Small molecule inhibits pathology associated with myotonic dystrophy type 1
10. K-States plant pathology head named fellow of Phytopathology Society
11. Tips from the American Journal of Pathology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2013)... have developed a novel technique that can detect molecular ... that is one of the most important, though time-consuming, ... a paper in Nature , post-doctoral researcher David ... Schnell of the Center for Free-Electron Laser Science (CFEL) ... finely-tuned microwave fields to identify molecular variants apart, and ...
(Date:5/22/2013)... 2013)The omega 3 fatty acids in fish oil have ... so that the American Heart Association currently recommends eating ... fatty varieties rich in omega 3s. However, the mechanism ... a new study, scientists led by Jason R. Carter ... by providing evidence that fish oil might specifically counteract ...
(Date:5/22/2013)... human health effects from disposal of millions of ... to recommend stronger government policies to encourage recovery, ... That,s the conclusion of a new paper in ... . , Oladele A. Ogunseitan and colleagues point ... powering everything from smart phones to components in ...
Breaking Biology News(10 mins):Detecting mirror molecules 2Detecting mirror molecules 3Fish oil may help the heart beat mental stress 2
... into an aggressive sexual frenzy. Researchers writing in the ... a urine-mediated combination of aggressive and reproductive behaviour ensures ... Fiona Berry and Thomas Breithaupt from the University of ... on sexually active crayfish. Breithaupt said, "Our results confirm ...
... SEATTLE University of Washington (UW) researchers have gathered ... by overproducing protein-digesting enzymes. Plaques are fat-laden rough spots ... plaque ruptures, blood accumulates inside of it, a process ... clots can form. If the flow of oxygen-rich blood ...
... Five prominent physicists from leading U.S. and European universities will ... a daylong symposium presented by the Physics Department at The ... April 23, at The Harmonie Club in New York, will ... doctorate on Sy Sternberg, ,65 EE, former chairman and chief ...
Cached Biology News:Dangerous plaques in blood vessels rupture by overproducing protein-busting enzymes 2Dangerous plaques in blood vessels rupture by overproducing protein-busting enzymes 3Dangerous plaques in blood vessels rupture by overproducing protein-busting enzymes 4CCNY symposium April 23 to explore future of physics 2CCNY symposium April 23 to explore future of physics 3
(Date:5/23/2013)... 2013 During the conduct of ... adhere to principles of good clinical practice (GCP) ... Dr. Jeremy Lim, Fellow, Clinical Development at Novartis ... ,     Understand the International Conference on Harmonization (ICH) ... regulations for the conduction of clinical trials , ...
(Date:5/23/2013)... Bed bugs compromised Penn State. A report ... Meanwhile, My Cleaning Products offered complimentary samples of its bed ... without using harmful chemical elements. , Based on the ... building was actually a dormitory , My Cleaning Products ... May 13 and bed bug presence was confirmed on May ...
(Date:5/22/2013)... Industry leaders from around the ... Oak Ridge National Laboratory’s Biosurveillance Symposium ... the Hilton Alexandria Mark Center. Held in conjunction ... conference on June 18 - 19. , Join ... Elements, Applied Research Associates, ARA, AttaGene, Battelle, Benedictine ...
(Date:5/22/2013)... 22, 2013  Empire Genomics announced today it ... pending novel genomic biomarker from Cornell University for ... could help in diagnosing and determining treatment for ... Neuroendocrine prostate cancer (NEPC) is a lethal ... de novo, but more commonly arises after hormonal ...
Breaking Biology Technology:Adhering to Good Clinical Practice, New Webinar Hosted by Xtalks 2Penn State Dorm Infested with Bed Bugs, My Cleaning Products Offers Complimentary Sample of Bed Bug Spray to Help Bed Bug Victims 2Biodetection Technologies 2013 and Oak Ridge National Lab’s Biosurveillance Symposium to Bring Together Leading Organizations in Alexandria, VA from June 17-19, 2013 2Biodetection Technologies 2013 and Oak Ridge National Lab’s Biosurveillance Symposium to Bring Together Leading Organizations in Alexandria, VA from June 17-19, 2013 3Biodetection Technologies 2013 and Oak Ridge National Lab’s Biosurveillance Symposium to Bring Together Leading Organizations in Alexandria, VA from June 17-19, 2013 4Biodetection Technologies 2013 and Oak Ridge National Lab’s Biosurveillance Symposium to Bring Together Leading Organizations in Alexandria, VA from June 17-19, 2013 5Empire Genomics Licenses Novel DNA Biomarker for Use in Diagnosing and Creating a Companion Diagnostic Test for Neuroendocrine Prostate Cancer 2
... Novagali Pharma, a French,pharmaceutical ophthalmic company, announces ... (IND) to conduct a Phase III clinical,trial ... glaucoma has been,granted by the U.S. Food ... ocular proprietary BAK-free formulation of latanoprost which,furthermore ...
... Milestone Payment from GlaxoSmithKlineMOUNTAIN VIEW, Calif., May 5 ... identified an orally bioavailable small molecule antagonist of ... clinical development. The acceptance of the molecule ... milestone payment from the alliance with GlaxoSmithKline (NYSE: ...
... May 5 Amylin Pharmaceuticals, Inc., (Nasdaq: ... LLY ) and Alkermes, Inc. (Nasdaq: ALKS ) ... once weekly has been submitted to the U.S. Food and ... release medication for type 2 diabetes that is injected subcutaneously ...
Cached Biology Technology:Novagali Pharma Announces FDA Clearance of IND for Phase III of Catioprost(R), its Cationic Emulsion of Latanoprost in Patients With Glaucoma 2ChemoCentryx Identifies Novel Small Molecule C5aR Antagonist 2ChemoCentryx Identifies Novel Small Molecule C5aR Antagonist 3ChemoCentryx Identifies Novel Small Molecule C5aR Antagonist 4Exenatide Once Weekly New Drug Application Submitted to FDA for Type 2 Diabetes 2Exenatide Once Weekly New Drug Application Submitted to FDA for Type 2 Diabetes 3Exenatide Once Weekly New Drug Application Submitted to FDA for Type 2 Diabetes 4Exenatide Once Weekly New Drug Application Submitted to FDA for Type 2 Diabetes 5Exenatide Once Weekly New Drug Application Submitted to FDA for Type 2 Diabetes 6Exenatide Once Weekly New Drug Application Submitted to FDA for Type 2 Diabetes 7
Porcine Coronary Artery Smooth Muscle Cells (PCASMC) (>500,000 cells)...
... DNA Ligase catalyzes the joining of two ... the 3´-hydroxyl groups of adjacent nucleotides in ... The enzyme has also been shown to ... a DNA or RNA strand in a ...
... to MAP1 Light Chain MAP1A and MAP1B ... between microtubules and components of the cytoskeleton. MAP1A ... subunit and multiple light chain subunits. The protein ... light chain subunits and can associate with either ...
PC based system for advanced chemifluorescent, chemiluminescent, fluorescent and colorimetric, microarray and microscope imaging and analysis....
Biology Products: