Navigation Links
Pathogen study explores blocking effect of E. coli O157:H7 protein
Date:12/13/2013

MANHATTAN, KAN. -- Often the key to any victory is to fully understand your opponent. This is especially true when that opponent is a significant foodborne bacterial pathogen such as E. coli O157:H7.

Philip Hardwidge, associate professor at the College of Veterinary Medicine at Kansas State University, is studying how pathogens such as E. coli use proteins to block a host's innate immune system. This system is the body's first defense against infection, often presented in the body's mucosal surfaces such as those found in the intestine.

"In terms of infectious disease, this inhibition of the human innate immune response is absolutely critical for the bacteria's ability to cause an infection," said Hardwidge, who works in the diagnostic medicine and pathobiology department. "If we can identify choke points in the interaction between the bacterium and the host, we may be able to inhibit the bacterium and prevent its survival in an infected human being."

Hardwidge's lab received a multiyear grant from the National Institutes of Health to explore a protein expressed by pathogenic E. coli known as NleH1, which inhibits an important cellular signaling pathway called IKK/NF-B, or I-Kappa-Kinase/N-F-Kappa-B.

"This protein is one example of an injected bacterial protein that is able to block the innate immune system," Hardwidge said. "This protein has kind of an unusual mechanism that had not been seen in other bacterial or viral pathogens, so we're interested in understanding more about how this protein really works and whether it represents a good target for future therapeutics.

The exploration of these host-pathogen interactions requires the lab to use multidisciplinary approaches, including using animal models and advanced technologies such as quantitative polymerase chain reaction, or PCR.

"One of beauties of QPCR, or quantitative PCR, is that it gives a really reliable and easily to def
'/>"/>

Contact: Philip Hardwidge
hardwidg@vet.k-state.edu
785-532-2506
Kansas State University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. New technique identifies pathogens in patient samples faster, in great detail
2. Study to identify functions of hypothetical genes in 2 infectious disease pathogens
3. Tuberculosis genomes portray secrets of pathogens success
4. Helper cells aptly named in battle with invading pathogens
5. Resistance gene found against Ug99 wheat stem rust pathogen
6. Recent progress in gene-sensing strategies for rapid detection of foodborne pathogens
7. Discovery of how a gene that regulates factors involved in bacteria pathogenicity acts
8. University of Toronto breakthrough allows fast, reliable pathogen identification
9. Pathogen turns protein into a virulence factor in 1 easy step
10. Predicting the next eye pathogen; analysis of a novel adenovirus
11. Vaccine adjuvant uses host DNA to boost pathogen recognition
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Pathogen study explores blocking effect of E. coli O157:H7 protein
(Date:8/1/2014)... of a new study, including two Simon Fraser ... industry representatives and policymakers must collaborate closely on ... gas development. Viorel Popescu and Maureen Ryan, David ... Sciences department, are among eight international co-authors of ... Ecology and the Environment . , Shale gas ...
(Date:7/31/2014)... natural-gas production from shale rock has increased by ... still do not fully understand the industry,s effects ... in the journal Frontiers in Ecology and ... to vastly outpace scientific examination, a team of ... including Princeton University, concluded that determining the environmental ...
(Date:7/31/2014)... prestin was found to be a key gene responsible for ... the hair cells of the inner ear that contracts and ... an antique phonograph horn, amplify sound waves to make hearing ... in the advanced online edition of Molecular Biology and ... has also independently evolved to play a critical role in ...
Breaking Biology News(10 mins):Scientists warn time to stop drilling in the dark 2Scientists warn time to stop drilling in the dark 3'Fracking' in the dark: Biological fallout of shale-gas production still largely unknown 2'Fracking' in the dark: Biological fallout of shale-gas production still largely unknown 3
... the world, this week,s edition of Chemical & Engineering ... on the jobs situation for chemists -- whose work directly ... chemical industry in the United States alone a $674 billion ... American Chemical Society, the world,s largest scientific society. ...
... life scientists have identified a gene that slows the aging ... activated a gene called PGC-1, which increases the activity of ... growth and tell cells when to live and die. ... in different cells and tissues of the fly and asked ...
... tree outside Oak Ridge National Laboratory researcher Pratul Agarwal,s ... may ultimately lead to drugs with fewer side effects, ... breeze causes leaves, branches and ultimately the tree to ... of chemical processes that have a ripple effect necessary ...
Cached Biology News:UCLA biologists slow the aging process in fruit flies 2UCLA biologists slow the aging process in fruit flies 3ORNL fundamental discovery casts enzymes in new light 2
(Date:8/1/2014)... ON (PRWEB) August 01, 2014 ... has led to a better understanding embryonic development. ... and reorganize into structurally and functionally distinct tissues ... physical defects. Prof. Todd McDevitt, Melissa Kinney, ... biophysical signals interact with biochemical cues to control ...
(Date:7/31/2014)... City, CA (PRWEB) July 31, 2014 ... as consumers, are increasingly searching for food alternatives ... and nutritional benefits. The food ingredient market has ... budding players such as Vital Force Technology (VFT). ... with more than 4,000 energetic patterns, all tested ...
(Date:7/31/2014)... 2014 “2014 Deep Research ... Industry” is a professional and in-depth research ... introduces Polyurethane Resin basic information, including its ... and industry overview. This research covers the ... as well as global industry analysis covering ...
(Date:7/31/2014)... Today BioSpace , the leading life sciences employment and news website, ... sciences community in Illinois , Indiana ... Michigan , Minnesota , Missouri ... and Wisconsin . BioMidwest is a leader ... on BioSpace originating in this region in 2013. The life sciences sector ...
Breaking Biology Technology:Study Links Biomechanics and Gene Expression in Stem Cells 2Functional Ingredient Manufacturer – Vital Force Technology Infuses Raw Materials & Ingredients with Subtle Energy Formula 2Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 2Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 3Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 4Midwest Biotech Leaders Featured On BioSpace Map 2
... Leading US Spine Centers Committed to the IEP,s ... 24 Magnifi Group, considered by,many industry observers ... within the medical device and pharmaceutical industries,announced here ... annual,meeting, its intent to organize and develop real-time ...
... Efforts to ... MENTOR, Ohio, Oct. 24 STERIS Corporation,(NYSE: STE ... its,VaproSure(TM) Room Sterilizer from several U.S. hospitals. The VaproSure,Room Sterilizer ... kind for the healthcare market. Since being introduced in,June of ...
... Cell Therapeutics,Inc. (CTI) (Nasdaq and MTAX: ... annual AACR-NCI-EORTC Symposium show its bis-platinate drug,candidates, ... currently,marketed platinum agents carboplatin, cisplatin and oxaliplatin. ... late 2008. "Bis-platinates represent a promising ...
Cached Biology Technology:Magnifi Group Demonstrates Industry's First Interactive Educational Program (IEP) for Spine Fellows 2Hospitals Adopt STERIS Advanced Room Sterilization Technology in the Fight Against 'Superbugs' 2Hospitals Adopt STERIS Advanced Room Sterilization Technology in the Fight Against 'Superbugs' 3Hospitals Adopt STERIS Advanced Room Sterilization Technology in the Fight Against 'Superbugs' 4Hospitals Adopt STERIS Advanced Room Sterilization Technology in the Fight Against 'Superbugs' 5Hospitals Adopt STERIS Advanced Room Sterilization Technology in the Fight Against 'Superbugs' 6First New Class of Platinum-Based Chemotherapy Drug Candidates in 30 Years Demonstrate Ability to Kill Tumors Resistant to Currently Marketed Platinum Drugs 2First New Class of Platinum-Based Chemotherapy Drug Candidates in 30 Years Demonstrate Ability to Kill Tumors Resistant to Currently Marketed Platinum Drugs 3
... you reduce the chance of error. Thats ... Developed using Beckman Coulters extensive experience in ... technology, the CEQ 8000 is a fully ... fills the capillary array with a patented ...
... monoclonal [6331] to Salmonella typhimurium The genus ... The genus is composed of Gram-negative bacilli that ... major antigens; the "H" or flagellar antigen (phase ... (part of the LPS moiety) and the "Vi" ...
... Antigen sequence: H-Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH ... For our corresponding peptide ... 2 5 I-labelled ... (human) (H-1470) and ([ ...
This free-standing laminar flow hood provides a horizontal flow of HEPA-filtered air to create a clean processing area. Air return slots along the front and side edges of the work area enhance system...
Biology Products: