Navigation Links
Particular DNA changes linked with prostate cancer development and lethality
Date:4/21/2013

A new analysis has found that the loss or amplification of particular DNA regions contributes to the development of prostate cancer, and that patients with two of these DNA changes have a high likelihood of dying from the disease. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the study provides valuable information on the genetics of prostate cancer and offers insights into which patients should be treated aggressively.

Cells can become cancerous when they lose or amplify pieces of DNA containing important genes. Using a method that can detect these genetic changes in cells from prostate tumors from 125 patients, Jianfeng Xu, MD, DrPh, Director of the Center for Cancer Genomics at the Wake Forest School of Medicine in Winston-Salem, and his colleagues at Wake Forest, Brady Urological Institute of Johns Hopkins Medical Institutions, and Karolinska Institute of Sweden found that changes in 20 gene regions likely contribute to prostate cancer development. Four of these regions had not been reported before. Importantly, changes in seven of the 20 regions were linked with early death from prostate cancer. Also, patients whose cancer cells had a loss of the PTEN gene and an amplification of the MYC gene were more than 50 times as likely to die from prostate cancer than other patients who had similarly staged tumors and prostate-specific antigen levels at the time of diagnosis. Analyses of 333 tumors from additional patients confirmed the link between PTEN and MYC and prostate cancer lethality.

In addition to providing new information about the genetic changes involved in the development and progression of prostate cancer, the findings may help guide doctors as they weigh different treatment options for patients with the disease. "For example, prostate cancer patients who have DNA copy number alterations at PTEN and MYC may not be appropriate candidates for active surveillance and should be treated i
'/>"/>

Contact: Amy Molnar
sciencenewsroom@wiley.com
Wiley
Source:Eurekalert

Page: 1 2

Related biology news :

1. UCSB researchers discover particularly dangerous Salmonella
2. Positive effect of white button mushrooms when substituted for meat on body weight and composition changes during weight loss and weight maintenance
3. TGen-led study discovers dramatic changes in bacteria following male circumcision
4. Pregnancy permanently changes foot size
5. Changes to DNA on-off switches affect cells ability to repair breaks, respond to chemotherapy
6. Cultural evolution changes bird song
7. Can changes in nutrition labeling help consumers make better food choices?
8. Pediatric coding top tips and pediatric CPT changes 2013
9. Will changes in climate wipe out mammals in Arctic and sub-Arctic areas?
10. Small changes in eating prompts weight loss
11. Researcher finds gender differences in seasonal auditory changes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2014)... by neurobiologist Luke Remage-Healey at the University of ... the brains of young birds enhance their ability ... development. This period has a parallel to universal ... separate study, the UMass Amherst neuroscientist and colleagues ... the brain,s auditory cortex enhances the representation of ...
(Date:7/21/2014)... runoff is causing problems for the world,s water ... Agency found stormwater runoff to be one of ... rivers, streams, lakes, ponds, reservoirs, bays, and estuaries. ... fish and wildlife populations, foul drinking water, and ... Carolina State University are looking to rain gardens ...
(Date:7/21/2014)... Cystoid macular edema (CME) is a common complication ... in which patients typically lose night and side vision ... also decrease central vision. Current treatments for CME in ... adverse results. , Researchers from the Massachusetts Eye and ... Medicine tested whether the extent of retinal swelling due ...
Breaking Biology News(10 mins):Studying estrogens made by the brain may offer new insights in learning and memory 2Studying estrogens made by the brain may offer new insights in learning and memory 3Filter bed substrates, plant types recommended for rain gardens 2Iodine may alleviate swelling in retinitis pigmentosa patients' retinas 2
... have much in common with a Rottweiler, you might be ... a cave in the Altai Mountains of Siberia for 33,000 ... domestication and, together with equally ancient dog remains from a ... occurred repeatedly in different geographic locations rather than with a ...
... is available in German . Mate ... animal species. During mating season male testosterone levels rise, ... features. Male bonobos, however, invest much more into friendly ... collide with this increased tendency towards forming pair-relationships. ...
... 26 million Americans with diabetes, drawing blood is the ... invasive and at least minimally painful. Researchers at Brown ... check blood sugar levels by measuring glucose concentrations in ... convergence of nanotechnology and surface plasmonics, which explores the ...
Cached Biology News:Dog skull dates back 33,000 years 2Dog skull dates back 33,000 years 3Bonobos' unusual success story 2Biochip measures glucose in saliva, not blood 2Biochip measures glucose in saliva, not blood 3
(Date:7/18/2014)... 18, 2014  On July 18, 2014, ... Shire,s complementary fit and the benefits of ... of the infographic materials will be available ... In accordance with Rule 30.4 ... this announcement will be available on AbbVie,s ...
(Date:7/18/2014)... , July 18, 2014 ... in Animal Research for the third consecutive year. The ... University, will attend a 1-week course at Zürich University ... the 3Rs (Replace, Reduce, Refine). As head of the ... has been given the task of adapting experimental animal ...
(Date:7/17/2014)... Pharmaceuticals Inc. (Vanda) (NASDAQ: VNDA ), a ... products for the treatment of central nervous system disorders, ... quarter of 2014 on Thursday, August 7, 2014, before ... host a conference call at 10:00 AM ET on ... discuss the second quarter 2014 financial results and other ...
(Date:7/17/2014)... MELBOURNE, Australia , July 17, 2014  Prana ... today provided an update on its clinical development program ... , the Florey Institute of Neuroscience and Mental Health, ... Prana,s Phase 2 IMAGINE and EURO trials in his ... Copenhagen, Denmark . The presentation ...
Breaking Biology Technology:NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION 2NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION 3NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION 4NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION 5NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION 6NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION 7Young Moscovite Researcher Receives this Year's "Basel Declaration Award for Education in Animal Research" 2Vanda Pharmaceuticals to Announce Second Quarter 2014 Financial Results on August 7, 2014 2Prana Alzheimer's disease Development Program update 2Prana Alzheimer's disease Development Program update 3Prana Alzheimer's disease Development Program update 4Prana Alzheimer's disease Development Program update 5
... www.mchange.org Milwaukee As the highway reconstruction ... leveled at the amount of money, $685,000, spent on a ... , ,The Web site for the Marquette Interchange Project ... a joint venture between the consultants working on the interchange, ...
... sell advertising to competitors of Geico Corp. who use ... court in Virginia has ruled. Advertising based on Web ... Googles business. In the third quarter, about half of ... also called sponsored links. , ,This case involved ...
... companies out there will give you a logo at no cost, ... free Web site. I guess the nextbig thing will be that ... and how are they doing this? , ,The Internet has removed ... issues in real time without the fancy decorum and the big-time ...
Cached Biology Technology:$685,000 too much for construction Web site, critics say 2$685,000 too much for construction Web site, critics say 3Google wins first battle in trademark war 2Free branding? Why not? 2Free branding? Why not? 3
GOAT ANTI FRK...
... Spots and complementary RNA Spikes for the ... for glass array printing and for protocol ... cDNA labeling, hybridization stringency and background. Normalize ... Spots and Oligo Spots, and complementary RNA ...
MOUSE ANTI S. MUTANS PEPTIDOGLYCAN...
For the quantitative determination of canine Interleukin 10,(IL-10) concentrations in cell culture supernates, canine serum,and plasma....
Biology Products: