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Parkinson's Disease Foundation announces award of $150,000
Date:10/23/2008

(October 23, 2008, New York, NY) The Parkinson's Disease Foundation (PDF) is pleased to announce an award of $150,000 toward investigations studying the potential of individualized stem cell therapy to treat Parkinson's disease (PD).

The grant will support the research of Marina Emborg, M.D., Ph.D., and Su-Chun Zhang, M.D., Ph.D., both of the University of Wisconsin, Madison. This award was chosen as part of PDF's mission to fund scientific research that has great potential to increase our understanding of Parkinson's and to find treatments and a cure.

Dr. Emborg and Dr. Zhang will be conducting a pilot study that examines the use of transformed adult skin cells in the treatment of Parkinson's. Scientists can now direct the skin cells of a person with Parkinson's to become pluripotent stem cells (iPS), which appear to have similar potential to embryonic stem cells. This means that iPS cells can change into any other type of cell in the body, including dopamine neurons the very cells that are damaged in the brains of people with Parkinson's. Scientists theorize that transplanting replacement cells in the brains of people with Parkinson's could ease symptoms of the disease. Though technical challenges lay ahead with the iPS method, its discovery has allowed researchers to sidestep ethical and political debates associated with using embryonic stem cells.

Dr. Zhang's laboratory will examine the potential of iPS cells by reverting skin cells of Rhesus monkeys into iPS cells and directing the cells to become dopamine neurons. Next, Dr. Emborg and her colleagues will insert the dopamine neurons produced by Dr. Zhang's team into the brains of the same animals that donated the skin cells animals who, through use of a compound called MPTP, have a condition much like Parkinson's disease. Dr. Emborg will observe how well these cells survive and integrate in the brain and she will measure the cells' effect on the health of the monkeys. F
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Contact: Melissa Barry
mbarry@pdf.org
212-923-4700
Parkinson's Disease Foundation
Source:Eurekalert

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