llow awardees, Sarah B. Berman, M.D., Ph.D., and Edward Burton, M.D., D.Phil., of the University of Pittsburgh in Pittsburgh, PA, are using their International Research Grant to investigate a more popular topic, the role of the mitochondria (the power plant of the cell) in Parkinson's. But their approach is unique. They will look for clues about the mitochondria by observing their movements in transparent zebrafish. By recording the motion of mitochondria as they migrate within the dopamine neurons and axons of a living animal, Dr. Berman and Dr. Burton hope to yield new insights into the role of the mitochondria in Parkinson's.
PDF Executive Director, Robin Anthony Elliott commented on the nature of this year's projects, "Time is of the essence for people with Parkinson's. Part of our responsibility to the community is to provide promising scientists with opportunities to pursue creative strategies to understanding the disease. Each of this year's research projects, in its own way, represents an innovative approach to solving Parkinson's. We look forward to seeing how they progress. "
Thomas Shiftan, M.D., a PDF research advocate who was part of the review committee noted, "After seeing first-hand the scientific debate among some of the world's leading Parkinson's experts, I am hopeful that we are pursuing Parkinson's from every angle possible. I am glad to play a role in PDF's team of researchers, advocates, clinicians and supporters in making a difference for people living with Parkinson's."
International Research Grants | $825,000
Designed to promote innovative research projects that have high potential to significantly advance the knowledge of Parkinson's.
Evaluating the Role of Mitochondrial Dynamics in Parkinson's Disease in an In Vivo Vertebrate Model: Real-Time Live Imaging of Mitochondrial Dynamics in Dopamine Neurons in Whole Zebrafish
Sarah Berman, M.D., Ph.D., and Edward Burton M.D., D.P
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