Navigation Links
Parkinson gene: Nerve growth factor halts mitochondrial degeneration
Date:1/30/2014

This news release is available in German.

Neurodegenerative diseases like Parkinson's disease involve the death of thousands of neurons in the brain. Nerve growth factors produced by the body, such as GDNF, promote the survival of the neurons; however, clinical tests with GDNF have not yielded in any clear improvements. Scientists from the Max Planck Institute of Neurobiology in Martinsried and their colleagues have now succeeded in demonstrating that GDNF and its receptor Ret also promote the survival of mitochondria, the power plants of the cell. By activating the Ret receptor, the scientists were able to prevent in flies and human cell cultures the degeneration of mitochondria, which is caused by a gene defect related to Parkinson's disease. This important new link could lead to the development of more refined GDNF therapies in the future.

In his "Essay on the Shaking Palsy" of 1817, James Parkinson provided the first description of a disease that today affects almost 280,000 people in Germany. The most conspicuous symptom of Parkinson's disease is a slow tremor, which is usually accompanied by an increasing lack of mobility and movement in the entire body. These symptoms are visible manifestations of a dramatic change that takes place in the brain: the death of large numbers of neurons in the Substantia nigra of the midbrain.

Despite almost 200 years of research into Parkinson's, its causes have not yet been fully explained. It appears to be certain that, in addition to environmental factors, genetic mutations also play a role in the emergence of the disease. A series of genes is now associated with Parkinson's disease. One of these is PINK1, whose mutation causes mitochondrial dysfunction. Mitochondria are a cell's power plants and without them, a cell can
'/>"/>

Contact: Dr. Rüdiger Klein
rklein@neuro.mpg.de
49-898-578-3151
Max-Planck-Gesellschaft
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Long-term spinal cord stimulation stalls symptoms of Parkinsons-like disease
2. Investigating the link between Parkinsons and pesticides
3. Genetic mutation increases risk of Parkinsons disease from pesticides
4. Gene-silencing study finds new targets for Parkinsons disease
5. UCLA, Emory researchers find a chemical signature for fast form of Parkinsons
6. Why psychosis is frequently associated with Parkinsons disease?
7. Lasers might be the cure for brain diseases such as Alzheimers and Parkinsons
8. Absence of the SMG1 protein could contribute to Parkinsons and other neurological disorders
9. Rare childhood disease may hold clues to treating Alzheimers and Parkinsons
10. PD map: Putting together the pieces of the Parkinsons puzzle
11. Garvan Institute receives grant to research role of long non-coding RNAs in Parkinsons disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Parkinson gene: Nerve growth factor halts mitochondrial degeneration
(Date:12/17/2014)... 15, 2014 Research and Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ... Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology ... http://photos.prnewswire.com/prnh/20130307/600769 Based on a ... introduces for the first time a fingerprint sensor in ...
(Date:12/17/2014)... Dec. 15, 2014  HITLAB SM announced today its ... confirm its adherence to current U.S. Food and Drug ... regulated smart device and smart phone application trials utilizing ... "HITLAB is determined to improve global healthcare ...
(Date:12/17/2014)... Research and Markets ( http://www.researchandmarkets.com/research/9zq33j/global_chemical ) has ... Market 2015-2019" report to their offering. ... trend upcoming in this market is the increasing demand ... in recording of patient data for quick and correct ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2
... the power of 21st century computing to confirm an idea ... cycles evolve faster. Their findings appear in the October 3rd ... consequence for the understanding of evolution made possible by the ... said senior author Michael Donoghue , the G. Evelyn ...
... Using computer models and live cell experiments, biomedical engineers at ... than 100 human protein fragments that can slow or stop ... Reporting online last week in the Proceedings ... the findings could lead to developing treatments to fight diseases ...
... has confirmed the appointment of Esin Gulari, dean of the ... on the National Science Board (NSB). President George W. Bush ... scientists. "This is a tremendous honor for me as ... I will be in a unique position to make contributions ...
Cached Biology News:Reproducing early and often is the key to rapid evolution in plants 2Discovery of natural compounds that could slow blood vessel growth 2US Senate confirms Clemson University engineering Dean Esin Gulari to National Science Board 2
(Date:1/22/2015)... 2015 Shimadzu Scientific Instruments today ... UV-visible spectrophotometer. Offering wavelength scanning from 190 to ... for applications in a variety of industries, including ... user-friendly UV-1280 enables intuitive operation, while the enhanced ...
(Date:1/22/2015)... 2015  Transwestern | RBJ today announces the firm brokered a ... Shire a leading biopharmaceutical company, at Two Ledgemont Center in ... Robert Richards , president, and Brian Cohen , senior ... five-floor building at 95 Hayden Ave. Photo - ...
(Date:1/22/2015)... Protocol Networks brings independent technology consulting to the ... consultants, Protocol Networks has recently announced its expansion into ... his company has attracted several clients in The Constitution ... as others. With the success of these engagements, Rogers ...
(Date:1/22/2015)... zFlo Motion , a US leader ... exciting product from a new partner. STT-Systems has ... past 15 years, with offerings in the optical-motion capture, 3D ... system (inertial measurement unit), iSen, is opening eyes around the ...
Breaking Biology Technology:Shimadzu’s New Monitored Single-Beam UV-Vis Spectrophotometer Offers Comprehensive Measurement Options in a Compact Body 2Transwestern?RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 23D Motion Capture Just Got Easy 2
... Wis. - The Fitchburg Plan Commission has recommended approval ... building and data center that would accommodate the expansion of ... the anchor tenant in both buildings, which are planned for ... Fitchburg Technology Campus . , ,The plans, which now go ...
... hero, she was heading to the tiny island nation of ... Indian Ocean. By all reports and expectations, she would be off ... disconnection. , ,Or maybe not. After 36 hours in ... made our way through customs and out into the humid night ...
... - Tanya Townsend didn't have much time to pass the ... many other information technology directors have an opportunity to start ... and new processes? , ,Not many, and when the ... shopping for a chief technology executive in 2004, Townsend beat ...
Cached Biology Technology:Berbee to expand at New Venture Center 2Coveted vacation "disconnect" was elusive 2Coveted vacation "disconnect" was elusive 3CIO Leadership Series: Tanya Townsend, Saint Clare's Hospital 2CIO Leadership Series: Tanya Townsend, Saint Clare's Hospital 3CIO Leadership Series: Tanya Townsend, Saint Clare's Hospital 4CIO Leadership Series: Tanya Townsend, Saint Clare's Hospital 5
sterile filtered, off the clot, all male donors, Total Protein: 4.5 to 8.5 g/dl...
One-step, colorimetric, linear detection range 0.7 mg/dL to 300 mg/dL. Procedure: 10 min....
Human alpha-1-antitrypsin. No cross-reactivity with alpha-1-acid glycoprotein, serum albumin or other serum proteins....
Recombinant Mouse LIGHT/TNFSF14...
Biology Products: