Navigation Links
Parental exposure to BPA during pregnancy associated with decreased birth weight in offspring
Date:5/5/2011

OAKLAND, Calif., May 5, 2011-- Parental exposure to bisphenol A (BPA) during pregnancy is associated with decreased birth weight of offspring, compared with offspring from families without parental BPA exposure in the workplace, according to Kaiser Permanente researchers.

The observational study is published in the current online issue Reproductive Toxicology.

Researchers explained that there was a greater magnitude of decrease in birth weight in children whose mothers were directly exposed to high BPA levels in the workplace during pregnancy, followed by those whose mothers were exposed to low levels of BPA in the workplace, then by those whose mothers had BPA exposure through father's high occupational BPA exposure, and finally, the least decrease in birth weight in the offspring whose mothers had BPA exposure through father's low occupational exposure.

Although the finding needs to be confirmed by additional studies, the study provides preliminary evidence that maternal exposure to BPA during pregnancy may have an adverse effect on fetal growth, said De-Kun Li, MD, PhD, the principal investigator of the study, senior author of the new publication, and a reproductive and perinatal epidemiologist at the Kaiser Permanente Division of Research in Oakland, Calif.

Exposure to BPA has been reported to reduce birth weight in animal studies at relatively high levels of exposure. Both animal and human studies have shown that BPA can pass through the placental barrier and that fetuses are likely to be exposed to similar (if not higher) levels of BPA as those of mothers, explained the researchers.

The study population was identified from a larger study of more than 1,000 male and female workers in factories in China. It compared workers in BPA-exposing facilities with a control group of workers in factories where no BPA was present. BPA-exposed (from the manufacturers of BPA and epoxy resin) and unexposed workers (from industries without BPA exposure), including their spouses and offspring, were recruited from 2003-2008.

Mothers in the mother-exposed group worked for at least three months during pregnancy. The researchers explained that it is possible that offspring in this group had relatively higher levels of in-utero BPA exposure than those in other groups. Spouses of exposed fathers, although not directly exposed to BPA in the workplace, were more likely to have a higher BPA exposure level than women in the unexposed group. Exposure in this group could occur through exposure to contaminated clothing, through workplace visits with spouses, and through residence proximity to factories, explained the researchers.

This study is the fourth in a series published by Dr. Li and his colleagues that examine the effect of BPA in humans. The first study, published in November 2009 in the Oxford Journals' Human Reproduction, found that exposure to high levels of BPA in the workplace increases the risk of reduced sexual function in men. The second study, published in May 2010 in the Journal of Andrology, found that increasing BPA levels in urine are associated with worsening male sexual function. The third study, published in Fertility and Sterility, showed that an increasing urine BPA level was significantly associated with decreased sperm concentration, decreased total sperm count, decreased sperm vitality and decreased sperm motility.

Funded by the U.S. National Institute of Occupational Safety and Health, this latest study adds to emerging human evidence questioning the safety of BPA, a chemical created in the production of polycarbonated plastics and epoxy resins found in baby bottles, plastic containers, the linings of cans used for food and beverages, and in dental sealants.

The researchers explained that BPA is believed by some to be a highly suspect human endocrine disrupter, likely affecting both male and female reproductive systems. These findings provide epidemiological evidence that has been lacking as the U.S. Food and Drug Administration and various other U.S. government panels have explored this controversial topic.

The present study was limited by the small sample size in the exposed group. Due to the retrospective nature of the study, estimated exposure levels in the past, rather than maternal urine BPA level, was used to classify the exposure dosage during the index pregnancy. Although researchers have demonstrated that the estimated BPA exposure was correlated with current urine BPA, it is still possible that the association between BPA exposure and birth weight was impacted due to inaccurate classification of BPA exposure categories.


'/>"/>

Contact: Danielle Cass
danielle.x.cass@kp.org
510-267-5354
Kaiser Permanente
Source:Eurekalert

Related biology news :

1. The effect of parental education on the heritability of childrens reading disability
2. Study to evaluate success of parental involvement in early childhood education
3. Study: Bird diversity lessens human exposure to West Nile Virus
4. Birth control has long-term effect on hormone exposure
5. Major source of radon exposure overlooked at former Ohio uranium-processing plant
6. Household exposure to toxic chemicals lurks unrecognized, researchers find
7. Study reveals effects of unconscious exposure to advertisements
8. Benefits of breastfeeding outweigh risk of infant exposure to environmental chemicals in breastmilk
9. Novel technique changes lymph node biopsy, reduces radiaiton exposure
10. Novel technique changes lymph node biopsy, reduces radiation exposure
11. Swimmers at public beaches show increased risk of exposure to contagious staph bacteria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/16/2016)... June 16, 2016 The ... expected to reach USD 1.83 billion by 2024, ... Research, Inc. Technological proliferation and increasing demand in ... expected to drive the market growth. ... The development of advanced multimodal techniques for ...
(Date:6/3/2016)... LONDON , June 3, 2016 /PRNewswire/ ... Transport Management) von Nepal ... ,Angebot und Lieferung hochsicherer geprägter Kennzeichen, einschließlich ... weltweit führend in der Produktion und Implementierung ... an der Ausschreibung im Januar teilgenommen, aber ...
(Date:5/24/2016)... Ampronix facilitates superior patient care by providing unparalleled technology to leaders of the medical ... premium product recently added to the range of products distributed by Ampronix. ... ... ... Ampronix News ...
Breaking Biology News(10 mins):
(Date:6/22/2016)... Research and Markets has announced the addition of the ... The global biomarkers market has ... The market is expected to grow at a five-year compound annual ... $50.6 billion in 2015 to $96.6 billion in 2020. ... to 2020) are discussed. As well, new products approved in 2013 ...
(Date:6/22/2016)... LOS ANGELES , June 22, 2016   ... an SNNLive Video Interview with Dr. Nader Pourhassan ... a biotechnology company focused on the clinical development and ... and prevention of HIV infection, according to the company,s ... was recorded on Tuesday, June 7 th , 2016, ...
(Date:6/22/2016)... DIEGO , June 22, 2016   ViaCyte, ... first pluripotent stem cell-derived islet replacement therapy for the ... presentations at ISSCR 2016 Annual Meeting.  ISSCR 2016, the ... to 25th at Moscone West in San Francisco.  ... of the presentations are as follows:Event: , Focus Session: ...
(Date:6/22/2016)... (PRWEB) , ... June 22, 2016 , ... ... at placing a spotlight on immigrant achievements and contributions to North Texas and ... most important contributors from the immigrant community to the civic and economic vitality ...
Breaking Biology Technology: