Navigation Links
Parasites ready to jump
Date:7/31/2009

Transposons are mobile genetic elements found in the hereditary material of humans and other organisms. They can replicate and the new copies can insert at novel sites in the genome. Because this threatens the whole organism, molecular mechanisms have evolved which can repress transposon activity. Professor Klaus Frstemann of the Gene Center of Ludwig-Maximilians-Universitt (LMU) in Munich and a team of researchers working with the fruitfly Drosophila melanogaster have now uncovered a new type of cellular defence that acts against DNA sequences present in high copy numbers inside the cell, even if they have not integrated into the genome. Small molecules of RNA (a class of nucleic acid closely related to the genetic material DNA) play the central role. "Transposons are genomic parasites, so to speak", says Frstemann. "If they are allowed to proliferate, the genome can become unstable or cancers can develop. We now want to find out whether mammalian cells possess this newly discovered defence mechanism and to elucidate precisely how it works." (EMBO Journal online, 30 July 2009.)

Transposons constitute a significant fraction of the genomes of most higher organisms. Indeed, it is estimated that these mobile elements, which include one or more genes, make up as much as half of the genetic material. "This demonstrates", says Frstemann, "that it is not always possible to tame these "selfish" genetic elements, although highly efficient mechanisms of defence have evolved. For instance, in the germ cells, which are required for reproduction, the system of so-called piRNAs ensures that transposon activity is inhibited but only if these RNAs are transmitted from the mother. Disruption of this system usually leads to a drastic reduction in the fertility of the progeny.

Germ cells are an ideal target for transposons, since these cells pass their genetic material together with integrated mobile elements on to all cells of the progeny. But normal
'/>"/>

Contact: Professor Klaus Frstemann
foerstemann@lmb.uni-muenchen.de
49-892-180-76912
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2

Related biology news :

1. Discovery to aid in future treatments of third-world parasites
2. Study finds role for parasites in evolution of sex
3. Immune genes adapt to parasites
4. Locking parasites in host cell could be new way to fight malaria
5. Scripps Florida scientists awarded $1.5M to fight major water and food parasites
6. Purifying parasites with light
7. Parasites outweigh predators in Pacific Coast estuaries
8. Study shows parasites outweigh predators
9. Monarch butterflies help explain why parasites harm hosts
10. Disrupting common parasites ability to talk to each other reduces infection
11. Parasites might spur evolution of strange amphibian breeding habits
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/16/2015)... , June 16, 2015 /CNW Telbec/ - handyem ... centralized around the incorporation of handyem,s HPC-150 portable ... laboratory, the Mo-POD™. This unprecedented model of mobile ... Conference at the Pennsylvania ... June 15 th to 18 th ...
(Date:6/16/2015)... Fingerprint Cards (FPC) raises the revenue guidance for ... at least 340 MSEK to that it will amount to ... growth and orders received the revenue guidance for 2015 is ... will exceed 1,500 MSEK to an updated guidance that revenue ... Due to receipt of orders of touch fingerprint sensors with ...
(Date:6/15/2015)... Conn. , Jun. 15, 2015 NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market, announces that ... be showcased to media at Digital Experience! @ NYC June ... summer showcase of the latest innovation in technology to over ... will be held at the Metropolitan Pavilion in ...
Breaking Biology News(10 mins):handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 2handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 3Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 2Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 3Wocket Smart Wallet Exhibiting at Pepcom Digital Experience! @ NYC June 18th 2Wocket Smart Wallet Exhibiting at Pepcom Digital Experience! @ NYC June 18th 3
... who have high blood sugar before undergoing surgery ... deep vein thrombosis and even pulmonary embolism after ... anesthesiology in the Artificial Pancreas Center at Jefferson ... and his colleagues examined records of nearly 6,500 ...
... light on how tiny molecular motors that transport materials ... , The knowledge could lead to better understanding of ... such as Down syndrome caused by faulty molecular motors, ... researchers said. For example, molecular motors are responsible for ...
... Two Boston University biomedical engineers have won a ... continue groundbreaking research aimed at reducing the cost ... , Boston University Associate Professor of Biomedical Engineering ... chosen for the NIH's National Human Genome Research ...
Cached Biology News:Jefferson scientists find high glucose before surgery raises risk of dangerous complications 2Researchers image molecular motor structural changes 2Researchers image molecular motor structural changes 3Researchers image molecular motor structural changes 4Boston University biomedical engineers win major grant for pursuit of the '$1,000 Genome' 2
(Date:7/7/2015)... ... July 07, 2015 , ... uBiome, the leading microbial genomics ... of microbiome sampling kits and full 16S laboratory analysis. The goal is to fast-track ... will also have access to their own dashboard, enabling them to view and compare ...
(Date:7/7/2015)... (PRWEB) , ... July 07, 2015 , ... ... membership driven community in the biometrical area. What began as a conference for ... global community for various functions in the biometrical area. Statistical Programmers, Data Managers ...
(Date:7/7/2015)... ... July 07, 2015 , ... Currently deployed ... was developed to solve many of the complex logistical and data management ... involve multiple clinical sites and/or remote data coordination centers. , CentrePoint drastically ...
(Date:7/6/2015)... ... July 06, 2015 , ... An optical ... reveal how blood flows in the brain during stroke, providing information that could ... new article published in the journal Neurophotonics describes work at the ...
Breaking Biology Technology:uBiome to Award Grant of up to $100k for Groundbreaking Microbiome Research 2uBiome to Award Grant of up to $100k for Groundbreaking Microbiome Research 3PhUSE Delighted to Welcome Member Number 5.000 2ActiGraph Launches CentrePoint Cloud-based Study Management Software Platform 2ActiGraph Launches CentrePoint Cloud-based Study Management Software Platform 3Reducing Stroke Damage May be Next Application for OCT Technology Now Widely Used in Eye and Vision Healthcare 2Reducing Stroke Damage May be Next Application for OCT Technology Now Widely Used in Eye and Vision Healthcare 3
... PDL BioPharma, Inc. (PDL, the Company) (NASDAQ: ... to market and other conditions, $135 million aggregate principal amount ... Company,s shelf registration statement filed with the U.S. Securities and ... expects to grant the underwriters a 13-day overallotment option to ...
... The U.S. Food and Drug Administration is requesting input ... of a user fee program for biosimilar and interchangeable ... http://photos.prnewswire.com/prnh/20090824/FDALOGO ) Biological products are produced in ... animal cell, while small molecule drugs are typically made ...
... May 9, 2011 Accuray Incorporated (Nasdaq: ... field of radiosurgery, announced today that the U.S. Securities ... S-4 Registration Statement relating to the previously announced acquisition ... in the registration statement will first be mailed to ...
Cached Biology Technology:PDL BioPharma, Inc. Announces Proposed $135 Million Public Offering of New Convertible Senior Notes Due 2015 2PDL BioPharma, Inc. Announces Proposed $135 Million Public Offering of New Convertible Senior Notes Due 2015 3PDL BioPharma, Inc. Announces Proposed $135 Million Public Offering of New Convertible Senior Notes Due 2015 4PDL BioPharma, Inc. Announces Proposed $135 Million Public Offering of New Convertible Senior Notes Due 2015 5FDA Requests Input on Development of User Fee Program for Biosimilar and Interchangeable Biological Products 2SEC Declares Accuray Form S-4 Registration Statement Effective in Proposed Acquisition of TomoTherapy 2SEC Declares Accuray Form S-4 Registration Statement Effective in Proposed Acquisition of TomoTherapy 3SEC Declares Accuray Form S-4 Registration Statement Effective in Proposed Acquisition of TomoTherapy 4
... sodium pyruvate, 50 mg/L streptomycin sulfate, 100 ... chloride, and magnesium chloride. The use of ... culture is generally attributed to early workers ... developed a solution of inorganic salts designed ...
This free-standing laminar flow hood provides a horizontal flow of HEPA-filtered air to create a clean processing area. Air return slots along the front and side edges of the work area enhance system...
... a dramatic breakthrough in accurate, small-volume bulk dispensing. ... the micro 1 has unique advantages not found ... 1 never needs re-calibration as do other 1mL ... an LCD Display , Graphical Row Selection , ...
... The B1 series embodies all aspects of ... microscope. With powerful Achromatic Super Contrast (ASC) ... imaging chip, this microscope combines flexibility and ... Motic's popular B1 series, the DM-B1 steps ...
Biology Products: