Navigation Links
Parasites ready to jump
Date:7/31/2009

Transposons are mobile genetic elements found in the hereditary material of humans and other organisms. They can replicate and the new copies can insert at novel sites in the genome. Because this threatens the whole organism, molecular mechanisms have evolved which can repress transposon activity. Professor Klaus Frstemann of the Gene Center of Ludwig-Maximilians-Universitt (LMU) in Munich and a team of researchers working with the fruitfly Drosophila melanogaster have now uncovered a new type of cellular defence that acts against DNA sequences present in high copy numbers inside the cell, even if they have not integrated into the genome. Small molecules of RNA (a class of nucleic acid closely related to the genetic material DNA) play the central role. "Transposons are genomic parasites, so to speak", says Frstemann. "If they are allowed to proliferate, the genome can become unstable or cancers can develop. We now want to find out whether mammalian cells possess this newly discovered defence mechanism and to elucidate precisely how it works." (EMBO Journal online, 30 July 2009.)

Transposons constitute a significant fraction of the genomes of most higher organisms. Indeed, it is estimated that these mobile elements, which include one or more genes, make up as much as half of the genetic material. "This demonstrates", says Frstemann, "that it is not always possible to tame these "selfish" genetic elements, although highly efficient mechanisms of defence have evolved. For instance, in the germ cells, which are required for reproduction, the system of so-called piRNAs ensures that transposon activity is inhibited but only if these RNAs are transmitted from the mother. Disruption of this system usually leads to a drastic reduction in the fertility of the progeny.

Germ cells are an ideal target for transposons, since these cells pass their genetic material together with integrated mobile elements on to all cells of the progeny. But normal
'/>"/>

Contact: Professor Klaus Frstemann
foerstemann@lmb.uni-muenchen.de
49-892-180-76912
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2

Related biology news :

1. Discovery to aid in future treatments of third-world parasites
2. Study finds role for parasites in evolution of sex
3. Immune genes adapt to parasites
4. Locking parasites in host cell could be new way to fight malaria
5. Scripps Florida scientists awarded $1.5M to fight major water and food parasites
6. Purifying parasites with light
7. Parasites outweigh predators in Pacific Coast estuaries
8. Study shows parasites outweigh predators
9. Monarch butterflies help explain why parasites harm hosts
10. Disrupting common parasites ability to talk to each other reduces infection
11. Parasites might spur evolution of strange amphibian breeding habits
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/16/2014)... of Nicaragua,s legal, artisanal green sea turtle fishery has ... of turtles in what may have become an unsustainable ... Society and University of Florida. , During the research ... turtles were killed between 1991 and 2011, with catch ...
(Date:4/16/2014)... Florida State University researchers have identified a new ... bone density and muscle mass with obesity. , "It ... were the better your bones would be because the ... Hazel Stiebeling Professor of Nutrition at Florida State. "But, ...
(Date:4/16/2014)... eyes up, and you cannot lift your upper eyelid. You walk ... look straight when they are rolled down in the eye socket. ... normal position of their head. In order to correct this condition, ... paper published in the April 16 print issue of the journal ...
Breaking Biology News(10 mins):Declining catch rates in Caribbean green turtle fishery may be result of overfishing 2Declining catch rates in Caribbean green turtle fishery may be result of overfishing 3Researchers: Obesity can amplify bone and muscle loss 2Researchers track down cause of eye mobility disorder 2
... as a model to study embryo formation, scientists report ... of a protein called Bicoid is vital to normal ... by the journal Dec. 19, the study shows how ... identified protein the researchers named Fates-shifted (Fsd). Without the ...
... Society has announced the winners of its second annual ... Annual Meeting at the Baltimore Convention Center in Baltimore, ... Professional Opportunities for Women, has initiated these travel fellowships ... their participation at the Meeting. The recipients of ...
... The prolonged, extensive emission of greenhouse gases over ... ocean life, according to a study by UC Merced ... emissions exacerbated by the burning of fossil fuels ... more acidic, and Beman,s study shows that the increased ...
Cached Biology News:Fruit fly study digs deeper into poorly understood details of forming embryos 2Biophysical Society announces winners of 2011 CPOW Travel Awards 2Rising greenhouse gases profoundly impact microscopic marine life 2
(Date:1/14/2014)... San Diego, CA (PRWEB) January 14, 2014 ... based on the products of cells grown under simulated ... an international license agreement with Suneva Medical, Inc. for ... media (CCM). , This agreement is an ...
(Date:1/14/2014)... EquitiesIQ, a leading informational research provider, ... is an emerging biomedical company acquiring, developing, manufacturing, and ... , Free report download: http://equitiesiq.com/reports/alliqua/ , In ... team and Board, which launched the company’s new strategy ...
(Date:1/14/2014)... iLab Solutions, the leader in core facility management software, ... Strategy. In this role, Michelle will work with current and ... the development of iLab products. Her main goal will be ... the scientific community by offering the most advanced, user-friendly, and ...
(Date:1/14/2014)... Global Record Systems, LLC, (GRS), ... solutions for patients, physicians, the biopharmaceutical industry, regulators, ... the signing of a three-year Research Collaboration Agreement ... (FDA). This initiative is designed to generate ...
Breaking Biology Technology:Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2
... Spherix Incorporated (Nasdaq: SPEX ), an ... and atherosclerosis; and providers of technical and regulatory consulting ... announced that it will host an investment community conference ... December 9, to discuss results of the Company,s Phase ...
... 6, 2010 Viruses have a bad rep—and rightly ... precisely replicate itself makes it a destructive scourge to ... researchers at the University of Maryland,s A. James Clark ... Resources, brought together by Professor Reza Ghodssi, is turning ...
... Todd Hutchings has assumed leadership of Egon Zehnder ... who led the practice, will continue at the firm ... executives. In his new role, Mr. Hutchings ... with boards and providing the full array of functional ...
Cached Biology Technology:Spherix to Hold Business Update Conference Call December 9, 2010 at 4:30 p.m. Eastern Time 2Bad Virus Put to Good Use: Breakthrough Batteries 2Bad Virus Put to Good Use: Breakthrough Batteries 3Bad Virus Put to Good Use: Breakthrough Batteries 4Bad Virus Put to Good Use: Breakthrough Batteries 5Bad Virus Put to Good Use: Breakthrough Batteries 6Egon Zehnder International Names Todd Hutchings to Lead Life Sciences Practice Group 2
Newborn Calf Serum US Origin...
SPDP-Trinitrophenol (TNP) Bovine Serum Albumin...
Acrylamide, 500 g. Assay: > 99.9%, acrylic acid: < 0.001%. Conductivity (35%): < 2 umhos/cm.Risks: 45, 46, 48, 23, 24, 25 ; Safety Precautions: 53, 44. Category: Nucleotides & Enzymes & Biochemicals...
HRP Monoclonal-Goat Diluent - 5X Concentrate, 25 mL...
Biology Products: